A5027012814- Drug Solubulity and Delivery Systems
- Analytical Chemistry and Chromatography
- Analytical Methods in Pharmaceuticals
- Adsorption, diffusion, and thermodynamic properties of materials
- Mesoporous Materials and Catalysis
- Granular flow and fluidized beds
- Advanced Radiotherapy Techniques
- 3D Printing in Biomedical Research
- Polysaccharides Composition and Applications
- Advanced Drug Delivery Systems
- Rheology and Fluid Dynamics Studies
- Crystallization and Solubility Studies
- Bone Tissue Engineering Materials
- Animal testing and alternatives
- Neuroendocrine Tumor Research Advances
- Enzyme Production and Characterization
- Contact Dermatitis and Allergies
- Lipid Membrane Structure and Behavior
- Microencapsulation and Drying Processes
- Gastrointestinal motility and disorders
- RNA Interference and Gene Delivery
- Fluid Dynamics and Heat Transfer
- Chemical Thermodynamics and Molecular Structure
- Drug Transport and Resistance Mechanisms
- Material Dynamics and Properties
Charles University
2016-2023
University of Hradec Králové
2016-2023
FHNW University of Applied Sciences and Arts
2020
University of Veterinary Sciences Brno
2013-2016
Liquisolid systems are an innovative dosage form used for enhancing dissolution rate and improving in vivo bioavailability of poorly soluble drugs. These formulations require specific evaluation methods their quality assurance (e.g., angle slide, contact angle, or water absorption ratio). The presented study is focused on the preparation, modern vitro testing, differences liquisolid containing varying amounts a drug liquid state (polyethylene glycol 400 solution rosuvastatin) relation to...
Liquisolid systems are modern formulations used to increase the bioavailability of poorly water-soluble drugs. Their preparation is based on sorption a drug in liquid state onto carrier with high adsorption capacity. The particles subsequently coated material having large surface area form free-flowing powder. main principle increasing presence dissolved drug, which ready for immediate absorption GI tract.Determination capability aluminometasilicate Neusilin® US2 adsorb different...
As coprocessed excipients (CPE) gain a lot of focus recently, this article compares three commercially available CPE Avicel brand, namely, CE 15, DG, and HFE 102. Comparison is based on measured physical properties mixtures, respectively, flow properties, pycnometric density, mean particle size, specific surface area, moisture content, hygroscopicity, solubility, pH leaching, electrostatic charge, SEM images, DSC. Tablets were made employing pressure sets. Viscoelastic ejection force...
Context: The preparation of liquisolid systems (LSS) represents a promising method for enhancing dissolution rate and bioavailability poorly soluble drugs. release the drug from LSS tablets is affected by many factors, including disintegration time.Objective: evaluation differences among containing varying amounts types commercially used superdisintegrants (Kollidon® CL-F, Vivasol® Explotab®).Materials methods: were prepared spraying rosuvastatin solution onto Neusilin® US2 further...
To enhance dissolution rate of meloxicam (MX), a poorly soluble model drug, natural polysaccharide excipient chitosan (CH) is employed in this work as carrier to prepare binary interactive mixtures by either mixing or co-milling techniques. The MX-CH three different drug loads were characterized for morphological, granulometric, and thermal properties well crystallinity. relative MX was determined phosphate buffer pH 6.8 using the USP-4 apparatus; significant increase observed both mixed...
Oligonucleotides (OND) represent a promising therapeutic approach. However, their instability and low intestinal permeability hamper oral bioavailability. Well-established for delivery, self-emulsifying drug delivery systems (SEDDS) can overcome the weakness of other such as long-term nanoparticles or complicated formulation processes. Therefore, present study aims to prepare SEDDS nonspecific fluorescently labeled OND across Caco-2 monolayer. The hydrophobic ion pairing an cationic lipid...
Bioavailability can be defined as the rate and range of active ingredient absorption, when it becomes available in systemic circulation or at desired site drug action, respectively. Drug bioavailability after oral administration is affected by anumber different factors, including physicochemical properties drug, physiological aspects, type dosage form, food intake, biorhythms, intra- interindividual variability human population. This article first from series dealing with methods leading to...
The utilization of co-processed excipients (CPEs) represents a novel approach to the preparation orally disintegrating tablets by direct compression. Flow, consolidation, and compression properties four lactose-based CPEs-Cellactose
There is increasing research interest in using mesoporous silica for the delivery of poorly water-soluble drugs that are stabilized a noncrystalline form. Most has been done on ordered silica, whereas far fewer studies have published nonordered and little known about intrinsic drug affinity to surface. The present mechanistic study uses inverse gas chromatography (IGC) analyze surface energies three different commercially available disordered grades phase. Using more drug-like probe molecule...
Good flow and compaction properties are necessary for the manipulation of particulate material in pharmaceutical industry. The influence addition an alternative sweetener, rebaudioside A, a concentration 0.2% w/w 0.5% on flow, shear sorbitol direct compaction, Merisorb® 200, was investigated this work. Rebaudioside A worsened sorbitol: Hausner ratio, compressibility index mass rate through aperture model hopper. Using Jenike cell revealed significant increase cohesion leading to decrease...
One of the modern technologies how to ensure sufficient bioavailability drugs with limited water solubility is represented by preparation liquisolid systems. The functional principle these formulations sorption a drug in liquid phase porous carrier (aluminometasilicates, microcrystalline cellulose, etc.). After addition further excipients, particular coating material (colloidal silica), powder formed properties suitable for conversion conventional solid unit dosage forms oral administration...
Bioavailability increasing of poorly soluble drugs has become one the main topics modern pharmaceutical technology. Many methods based on chemical modification, physical modification or new technological processes have been already used to improve bioavailability. Some these (e.g. micronization, preparation solid dispersions, formulation an inclusion complex, etc.) for many years successfully by companies. On other hand, such as liquisolid system and self-emulsifying drug delivery systems...