A5101537665- Alzheimer's disease research and treatments
- Neurological Disease Mechanisms and Treatments
- Neuroscience and Neuropharmacology Research
- vaccines and immunoinformatics approaches
- Mitochondrial Function and Pathology
- Bacteriophages and microbial interactions
- Neuroinflammation and Neurodegeneration Mechanisms
- Natural Antidiabetic Agents Studies
- Neurological Disorders and Treatments
- Antibiotic Use and Resistance
- Viral gastroenteritis research and epidemiology
- Supramolecular Self-Assembly in Materials
- Plant Reproductive Biology
- Analytical Chemistry and Chromatography
- Bacterial Infections and Vaccines
- Barrier Structure and Function Studies
- Protein Degradation and Inhibitors
- Advanced Chemical Sensor Technologies
- Streptococcal Infections and Treatments
- Diabetes and associated disorders
- Water Quality and Pollution Assessment
- Molecular Sensors and Ion Detection
- Infective Endocarditis Diagnosis and Management
- Hibiscus Plant Research Studies
- Pneumonia and Respiratory Infections
Jagannath University
2021-2024
Shimane University
2003-2024
Shahjalal University of Science and Technology
2023-2024
International Islamic University Malaysia
2021
An essential body of water close to Chandpur, Bangladesh, the Dakatia River plays an role local ecosystem and socioeconomic life. Seasonal fluctuations are important quality indicators, such as temperature, pH, dissolved oxygen (DO), electrical conductivity (EC), total solids (TDS), biological demand (BOD), chemical (COD), hardness, which examined in this study. In accordance with Environmental Conservation Rules (ECR, 2023), samples were taken during four seasons winter, summer, rainy...
Although the monkeypox virus-associated illness was previously confined to Africa, recently, it has started spread across globe and become a significant threat human lives. Hence, this study designed identify B T cell epitopes develop an epitope-based peptide vaccine against virus's surface binding protein through in silico approach combat monkeypox-associated diseases.The analysis revealed that of virus contains 30 19 within given parameter. Among epitopes, epitope "ILFLMSQRY" found be one...
Amyloid β (Aβ) peptide is deposited in the brains of sporadic Alzheimer’s disease (AD) due to impaired vessel-dependent clearance. To understand mechanisms, we investigated time-dependent cerebrovascular changes AD model mice. Cerebrovascular and other pathological were analyzed mice (J20 strain) aging from 2 9 months by immunostaining. At months, Aβ was only intraneuronal, whereas vessels positive 3 J20 Compared wild-type (WT), vessel density increased at but decreased mice, claudin-5...
Plasmalogens are alkenyl-acyl glycerophospholipids and decreased in post-mortem Alzheimer’s disease (AD) brains. The aim of this study is to investigate the time-dependent changes plasmalogens hippocampus an AD model mouse (J20). Plasmalogen levels at 3, 6, 9, 12 15 months were analyzed by liquid-chromatography-targeted-multiplexed-selected-reaction-monitoring-tandem-mass-spectrometry (LC-SRM/MS). Reactive oxygen species (ROS) evaluated using dichlorofluorescein diacetate (DCF-DA)....
Objective: Our study includes the investigation of phytochemical composition and in vitro free radical content antiinflammatory activity Mimosa pudica . Materials Method: Free scavenging assay was done to evaluate dose dependent reduction by ethanolic extract , this compared with a reference antioxidant i.e. Ascorbic acid. The anti-inflammatory potential has been determined using carrageenan-induced paw edema Cotton wool granuloma rats. Results: IC 50 our sample 24.55 μg/ml, it’s very much...
Plasmalogens (Pls) levels are reported to be altered in several neurological and metabolic diseases. Identification of sn-1 fatty alcohols sn-2 acids different Pls species is necessary determine the roles mechanisms action Previously, full-scan tandem mass spectrometry (MS/MS) was used for this purpose but not effective low-abundance species. Recently, multiplexed selected reaction monitoring MS (SRM/MS) found more selective sensitive than conventional MS/MS identification compounds. In...
Fluorocycline has been approved for the treatment of complicated intra-abdominal infections (cIAIs) caused by gram-positive and gram-negative bacteria in nosocomial infections. Especially, eravacycline is a unique synthetic fluorocycline antibacterial agent that belongs to tetracycline class. It acts against multidrug- resistant microorganisms such as carbapenem-resistant Enterobacteriaceae extended-spectrum β-lactamase-generating bacteria. Representing most advanced class tetracyclines,...
Abstract The global rise of antibiotic-resistant bacteria, particularly among Streptococcus species, poses an escalating public health threat. Traditional antibiotic development has proven inadequate, making innovative approaches such as bacteriophage-based therapies promising alternatives. A deep understanding phage biology at the genomic level is essential for advancing therapeutic applications. Here, we analyzed 709 genomes to bridge gaps in diversity and propose revisions taxonomy. were...
Phospholipid metabolism is reported to be altered in Alzheimer’s disease (AD). For a better understanding, we investigated the time-dependent changes of phospholipids species mouse model AD. The levels hippocampus and prefrontal cortex wild-type APP-Tg (J20) mice were measured by LC-ESI-MS/MS. Compared wild-type, total phosphatidylcholine (PC), phosphatidylethanolamine (PE), lysophosphatidylcholine (LPC) Increased at 3 months but decreased 6 J20 mice. Total lysophosphatidylethanolamine (LPE)...
<div>Abstract<p><b>Introduction:</b> BRM, a key catalytic subunit of the SWI/SNF chromatin remodeling complex, is putative tumor susceptibility gene that silenced in 15% non–small cell lung cancer (NSCLC). Two novel <i>BRM</i> promoter polymorphisms (<i>BRM</i>-741 and <i>BRM</i>-1321) are associated with reversible epigenetic silencing BRM protein expression.</p><p><b>Experimental Design:</b> Advanced NSCLC...