A5025406344- Mast cells and histamine
- Asthma and respiratory diseases
- Urticaria and Related Conditions
- Allergic Rhinitis and Sensitization
- Immunodeficiency and Autoimmune Disorders
- Immune Cell Function and Interaction
- Autoimmune Bullous Skin Diseases
- Eosinophilic Esophagitis
- Eosinophilic Disorders and Syndromes
- IL-33, ST2, and ILC Pathways
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Drug-Induced Adverse Reactions
- Food Allergy and Anaphylaxis Research
- Respiratory and Cough-Related Research
- Complement system in diseases
- Atherosclerosis and Cardiovascular Diseases
- Dermatology and Skin Diseases
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Cell Adhesion Molecules Research
- Pediatric health and respiratory diseases
- Obstructive Sleep Apnea Research
- Blood groups and transfusion
- Blood disorders and treatments
- Adipokines, Inflammation, and Metabolic Diseases
- Platelet Disorders and Treatments
Wake Forest University
2015-2024
W. G. (Bill) Hefner VA Medical Center
2015-2024
Winston-Salem State University
2023
Newark Academy
2023
Nationwide Children's Hospital
2022
Salisbury University
2022
Allergy, Asthma and Clinical Research Center
2021
Atrium Health Wake Forest Baptist
2014-2018
East Tennessee State University
2006-2017
Baptist Hospital
2017
Sib-pair analysis of 170 individuals from 11 Amish families revealed evidence for linkage five markers in chromosome 5q31.1 with a gene controlling total serum immunoglobulin E (IgE) concentration. No was found between these and specific IgE antibody concentrations. Analysis within subset 128 antibody-negative sib pairs confirmed to 5q31.1, especially the interleukin-4 ( IL4 ). A combination segregation maximum likelihood analyses provided further this linkage. These suggest that or nearby...
In spite of recent advances with experiments on animal models, strongyloidiasis, an infection caused by the nematode parasite Strongyloides stercoralis, has still been elusive disease. Though endemic in some developing countries, strongyloidiasis poses a threat to developed world. Due peculiar but characteristic features autoinfection, hyperinfection syndrome involving only pulmonary and gastrointestinal systems, disseminated involvement other organs, needs special attention physician,...
In Asian countries where the Buddhism and Taoism are mainstream religions, incense burning is a daily practice. A typical composition of stick consists 21% (by weight) herbal wood powder, 35% fragrance material, 11% adhesive 33% bamboo stick. Incense smoke (fumes) contains particulate matter (PM), gas products many organic compounds. On average, produces particulates greater than 45 mg/g burned as compared to 10 for cigarettes. The from include CO, CO2, NO2, SO2, others. also volatile...
Abstract A novel gene, designated ML-1, was identified from a human genomic DNA clone and T cell cDNA sequences. The second exon of ML-1 gene shares significant sequence identity with the encoding IL-17 (IL-17). expression up-regulated in activated PBMCs, CD4+ cells, allergen-specific Th0, Th1, Th2 clones, basophils, mast cells. Increased but not IL-17, seen following allergen challenge four asthmatic subjects, suggesting its role allergic inflammatory responses. transiently transfected...
Human mast cells are multifunctional capable of a wide variety inflammatory responses. Baicalein (BAI), isolated from the traditional Chinese herbal medicine Huangqin (Scutellaria baicalensis Georgi), has been shown to have anti-inflammatory effects. We examined its effects and mechanisms on expression cytokines in an IL-1beta- TNF-alpha-activated human cell line, HMC-1.HMC-1 were stimulated either with IL-1beta (10 ng/ml) or TNF-alpha (100 U/ml) presence absence BAI. assessed IL-6, IL-8,...
Abstract 4,4'-Diaminodiphenylsulphone (Dapsone) is widely used for a variety of infectious, immune and hypersensitivity disorders, with indications ranging from Hansen's disease, inflammatory disease insect bites, all which may be seen as manifestations in certain occupational diseases. However, the use dapsone associated plethora adverse effects, some involve pulmonary parenchyma. Methemoglobinemia resultant cyanosis, bone marrow aplasia and/or hemolytic anemia, peripheral neuropathy...
Abstract Background Altered levels of Immunoglobulin E (IgE) represent a dysregulation IgE synthesis and may be seen in variety immunological disorders. The object this review is to summarize the historical molecular aspects disorders associated with production. Methods Articles published Medline/PubMed were searched keyword specific terms such as class switch recombination, deficiency and/or disease conditions (atopy, neoplasia, renal disease, myeloma, etc.). selected papers included...
While most allergic responses to food are directed against protein epitopes and occur within 30 minutes of ingesting the allergen, recent studies suggest that delayed reactions may occur, sometimes mediated by IgE antibodies carbohydrate moieties. The objective this review is summarize clinical features management hypersensitivity mammalian meat galactose-alpha 1,3-galactose (alpha-gal), an oligosaccharide.A PubMed search was conducted with MeSH terms: galactosyl-(1,3) galactose,...
A panel of steady-state cytokine mRNAs was analyzed in the bronchoalveolar lavage (BAL) cells from asthmatic subjects or patients challenged with ragweed allergen. This achieved by combining both qualitative and quantitative assays using reverse transcription-polymerase chain reaction (RT-PCR). Analysis BAL six mild allergic five nonasthmatic, nonallergic showed no differences profile (including interleukin [IL]-Iβ, IL-2, IL-5, IL-6, IL-8, granulocyte/macrophage colony-stimulating factor),...