A5011813883- Neuroscience and Neuropharmacology Research
- Cannabis and Cannabinoid Research
- Neurotransmitter Receptor Influence on Behavior
- Memory and Neural Mechanisms
- Stress Responses and Cortisol
- Neural dynamics and brain function
- Nerve injury and regeneration
- Neurogenesis and neuroplasticity mechanisms
- Functional Brain Connectivity Studies
- Religion, Spirituality, and Psychology
- Liver Disease Diagnosis and Treatment
- Neurological disorders and treatments
- Photoreceptor and optogenetics research
- Biochemical effects in animals
- Obsessive-Compulsive Spectrum Disorders
- Diabetes and associated disorders
- Diet, Metabolism, and Disease
- Sleep and Wakefulness Research
Northwestern University
2022-2025
Vanderbilt University Medical Center
2019-2022
University of Puerto Rico System
2013-2018
ORIGINAL RESEARCH article Front. Behav. Neurosci., 08 August 2013Sec. Learning and Memory Volume 7 - 2013 | https://doi.org/10.3389/fnbeh.2013.00102
Cannabinoids modulate innate avoidance, threat-reactivity, and stress adaptations via modulation amygdala-associated circuits; however, the mechanisms by which cannabinoids amygdala representation of threat-related behavior are not known. We show that cannabinoid administration increases activity central (CeA) somatostatin neurons (SOM) alters basal network dynamics in a manner supporting generation antagonistic sub-ensembles within SOM population. Moreover, diverging neuronal population...
Maladaptive fear generalization is one of the hallmarks trauma-related disorders. The endocannabinoid 2-arachidonoylglycerol (2-AG) crucial for modulating anxiety, fear, and stress adaptation but its role in balancing discrimination versus not known. To address this, we used a combination plasma measurement neuroimaging from childhood maltreatment-exposed non-exposed mixed population combined with human rodent conditioning models. Here show that 2-AG levels are inversely associated at...
Abstract Maladaptive fear generalization is one of the hallmarks trauma-related disorders. The endocannabinoid 2-arachidonoylglycerol (2-AG) crucial for modulating anxiety, fear, and stress adaptation but its role in balancing discrimination versus not known. To address this, we used a combination plasma measurement neuroimaging from childhood maltreatment exposed non-exposed mixed population combined with human rodent conditioning models. Here show that 2-AG levels are inversely associated...
The prefrontal cortex is highly susceptible to the detrimental effects of stress and has been implicated in pathogenesis stress-related psychiatric disorders. It not well understood, however, how represented at neuronal level cortical ensembles. Even less understood representation changes over time with repeated exposure. Here we show that prelimbic ensemble foot shock exhibits rapid spatial drift within between sessions. Despite this ensemble, stressor itself stabilizes days. Our results...
The endogenous cannabinoid, 2-arachidonoylglycerol (2-AG), plays a key role in the regulation of anxiety- and stress-related behavioral phenotypes may represent novel target for treatment anxiety disorders. However, recent studies have suggested more complex 2-AG signaling stress responsivity, including increases acute fear responses after augmentation under some conditions. Thus, within distinct brain regions circuits could regulate anxiety-like behavior responsivity opposing manners....
Abstract Acquisition and extinction of associative fear memories are critical for guiding adaptive behavioral responses to environmental threats, dysregulation these processes is thought represent important neurobehavioral substrates trauma stress-related disorders including posttraumatic stress disorder (PTSD). Endogenous cannabinoid (eCB) signaling has been heavily implicated in the aversive we have recently shown that pharmacological inhibition 2-arachidonoylglycerol (2-AG) synthesis, a...