A5073513643- Asthma and respiratory diseases
- Cystic Fibrosis Research Advances
- Neonatal Respiratory Health Research
- Pediatric health and respiratory diseases
- Dermatology and Skin Diseases
- Metabolism and Genetic Disorders
- Food Allergy and Anaphylaxis Research
- Hearing Loss and Rehabilitation
- Hearing, Cochlea, Tinnitus, Genetics
- Child Nutrition and Feeding Issues
- Air Quality and Health Impacts
- Noise Effects and Management
- Breastfeeding Practices and Influences
- Child and Adolescent Health
- Health and Medical Studies
- Ear Surgery and Otitis Media
- Tracheal and airway disorders
- Infant Health and Development
- Bone and Dental Protein Studies
- dental development and anomalies
- Neonatal Health and Biochemistry
- Respiratory viral infections research
- Congenital Ear and Nasal Anomalies
- Ethics and Legal Issues in Pediatric Healthcare
- Infant Development and Preterm Care
Bayerisches Landesamt für Gesundheit und Lebensmittelsicherheit
2008-2024
Health and Safety Authority
2024
Technical University of Munich
2004-2014
Helmholtz Zentrum München
2008-2014
LMU Klinikum
2006-2007
Palo Alto Institute
2007
Albion (United States)
2007
Institute of Groundwater Ecology
2006-2007
University of Augsburg
2007
Universitätskinderklinik
2007
In vitro studies, animal experiments, and human exposure studies have shown how ambient air pollution increases the risk of atopic diseases. However, results derived from observational are inconsistent.To assess relationship between individual-based to traffic-related pollutants allergic disease outcomes in a prospective birth cohort study during first 6 years life.We studied 2,860 children at age 4 3,061 investigate diseases sensitization. Long-term particulate matter (PM(2.5)), PM(2.5)...
OBJECTIVE. Prophylactic feeding guidelines recommend a delayed introduction of solid foods for the prevention atopic diseases. Scientific evidence this is scarce. This study investigates whether solids (past 4 months or 6 months) protective against development dermatitis (AD) and sensitization when considering reverse causality. METHODS. Data from 2612 infants in an ongoing birth cohort were analyzed at 2 years age. Information on diet symptoms diagnoses AD was collected semiannually,...
Objectives: To estimate long-term exposure to traffic-related air pollutants on an individual basis and assess adverse health effects using a combination of pollution measurement data, data from geographical information systems (GIS) questionnaire data. Methods: 40 sites in the city Munich, Germany were selected at which collect particulate matter with 50% cut-off aerodynamic diameter 2.5 µm (PM ) measure PM absorbance nitrogen dioxide (NO 2 ). A pool GIS variables (information about street...
Current prophylactic feeding guidelines recommend a delayed introduction of solids for the prevention atopic diseases. This study investigates whether (past 4 or 6 months) is protective against development eczema, asthma, allergic rhinitis, and food inhalant sensitization at age years.Data from 2073 children in ongoing LISA birth cohort were analyzed years age. Multivariate logistic regression analyses performed all without skin symptoms within first months life to take into account reverse...
Summary Background Nutritional intervention with hydrolysed infant formulas has been shown efficacious in preventing eczema children predisposed to allergy. However, this preventive effect never related the natural course of or without a family history The aim study therefore was compare after nutritional eczema. Method prospective German birth cohort GINIplus includes total 5991 children, subdivided into interventional and non‐interventional groups. Children familial predisposition for...
T-cell receptor excision circle (TREC)-based newborn screening (NBS) for severe combined immunodeficiencies (SCID) was introduced in Germany August 2019.
To date, the precise etiology of molar-incisor hypomineralization (MIH) is uncertain. Vitamin D plays a key role in hard tissue formation. Therefore, this study aimed to analyze relationship between serum 25-hydroxy-vitamin (25(OH)D) status and dental health data obtained from 1,048 children 10-year follow-up Munich GINIplus LISAplus birth cohorts. The examination included diagnosis MIH recording (non-)cavitated caries lesions primary permanent teeth. Serum 25(OH)D concentrations were taken...
Abstract Objective: This epidemiological study aimed to assess the proportion and extent of manifestation enamel hypomineralization, including molar‐incisor‐hypomineralization (MIH), in permanent primary dentition. Methods: A total 693 children enrolled an ongoing birth cohort (GINIplus‐10) were examined at their 10‐year follow‐up. Enamel hypomineralization was scored dentition on a tooth‐ surface‐related level based criteria European Academy Paediatric Dentistry (EAPD). Children grouped...
The purpose of neonatal screening is the early detection congenital metabolic and endocrine disorders that, if untreated, could lead to fatal crises or other long-term adverse sequelae. In Germany, legally regulated. Quality-assurance reports ("DGNS reports") are created published annually by German Society for Neonatal Screening (Deutsche Gesellschaft für Neugeborenen-Screening). Data from DGNS years 2006-2018 serve as basis present publication.For 2006-2018, prevalences were calculated...
Abstract Aim: To describe day care attendance in Germany today (in former East and West Germany). investigate longitudinally whether children attending centres have an increased risk of acquiring common cold, bronchitis, pneumonia, otitis media or diarrhea. Methods: Questionnaire information was collected when the cohort were 6, 12, 18, 24 months, 4 6 years old. Day within first 2 life investigated with GEE (generalised estimating equations) methods relation to diarrhea life. Results: centre...
The objective of our study was to evaluate the association molar-incisor hypomineralizations (MIHs) with prospectively collected potential causative factors from first 4 years life, e.g. respiratory diseases, breastfeeding, maternal smoking and parental education. A total 692 children (10 old) GINI birth cohort participated. dental examination included registration enamel (EHs) according EAPD criteria. Children EH were sub-categorized into those at least one (MIH/1), a minimum on permanent...
Now that targeted therapies for spinal muscular atrophy are available, attempts being made worldwide to include screening in general newborn screening. In Germany, after pilot projects from 2018-2021, it was included the October 2021. To ensure a smooth transition, criteria follow-up were developed together with key stakeholders. At beginning of transition nationwide screening, false positive findings reported 3 patients. After optimization method laboratories concerned, all have been...
Abstract Newborn screening for cystic fibrosis (CF-NBS) was introduced in Germany 2016. Currently, systematic follow-up of positive CF-NBS results is not implemented or reimbursed the NBS program. We investigated confirmatory testing over 24 months after implementation a large German center before and introduction an active tracking system performed cost calculation tracking. Results are compared with federal state Bavaria, where centralized has been place many years. At center, 244 281,907...
Cystic fibrosis (CF) was added to the German newborn bloodspot screening (NBS) panel in 2016. This study assesses parental perceptions of CF-NBS and confirmatory testing.Prospective questionnaire-based survey administered parents children with positive over 40 months after initiation Southwest Germany. Parental were compared results from Bavaria Switzerland.Questionnaires 29 standardized questions sent 343 families born between October 2016 January 2020. A total 178 (51.9%) replied. Although...
Since 01.01.2009 in Germany a newborn hearing screening (UNHS) is obligatory for every child. The UNHS part of the guidelines prevention diseases children up to 6 years age (Kinder-Richtlinien). 2 after its introduction Bavaria, we now evaluate whether has been implemented successfully,and if quality criteria have met.In details procedure and are given. data from facilities Bavaria were evaluated process like coverage, method, REFER rate (rate failed tests) child at diagnosis.More than 96 %...