A5074171769- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Seaweed-derived Bioactive Compounds
- Echinoderm biology and ecology
- Marine Sponges and Natural Products
- Parasitic Infections and Diagnostics
- Metal complexes synthesis and properties
- SARS-CoV-2 and COVID-19 Research
- Animal Virus Infections Studies
- Natural product bioactivities and synthesis
- Microbial Natural Products and Biosynthesis
- Microbial Metabolites in Food Biotechnology
- Plant and animal studies
- Synthesis and Biological Activity
- Phytochemistry and Bioactive Compounds
- Carbon dioxide utilization in catalysis
- Macrophage Migration Inhibitory Factor
- Bee Products Chemical Analysis
- Peptidase Inhibition and Analysis
- Sesquiterpenes and Asteraceae Studies
- Plant chemical constituents analysis
- Marine Biology and Environmental Chemistry
- Drug-Induced Hepatotoxicity and Protection
- Marine and coastal plant biology
- Insect and Pesticide Research
Mexican Social Security Institute
2012-2024
Hospital de Especialidades
2019-2023
Secretaría de Investigación, Innovación y Educación Superior
2020-2022
University of Benin
2017
Center for Research and Advanced Studies of the National Polytechnic Institute
2013-2014
Purpose: The Omicron subvariant BA.1 of SARS-CoV-2 was first detected in November 2021 and quickly spread worldwide, displacing the Delta variant. In this work, a characterization variant Mexico is presented. Methods: time to fixation BA.1, diversity sublineages, population density, level virus circulation during inter-wave interval were determined analyze differences spread. Results: began spreading week December became dominant next three weeks, causing fourth COVID-19 epidemiological...
We prepared a series of 10 carbamates derivatives based on two common antiprotozoal drugs: metronidazole (1–5) and secnidazole (6–10). The compounds were tested in vitro against set amitochondriate protozoa: Giardia duodenalis Trichomonas vaginalis. Compounds 1–10 showed strong activities, with potency values the low micromolar-to-nanomolar range, being more active than their parent drugs. Metronidazole carbamate (1) was most series, nanomolar activities G. (IC50 = 460 nM) T. vaginalis 60...
Few studies have been carried out on the medical flora of Mexico’s Yucatan Peninsula in search for new therapeutic agents, particular against cancer. In this paper, we evaluated cytotoxic potential extract Bonellia albiflora , a plant utilized traditional Mayan medicine treatment chronic injuries mouth. We methanolic extracts different parts by means extraction with Soxhlet equipment. conducted liquid-liquid fractions each solvents increasing polarity. All and were activity versus four human...
This study aimed to evaluate the in vitro activity of extracts two marine sponge species, occurring shallows Yucatan peninsula coast, on cancer and one normal mammalian cell lines. Hexane, dichloromethane, ethyl acetate methanol Halichondria magniconulosa melanadocia were screened for their cytotoxic against hormone-dependent breast (MCF-7) human cervix (SiHa) The extract H. exhibited significant cytotoxicity MCF-7 cells a CC50 0.8 µg/mL, as well high selectivity (SI = 24.5). On other hand,...
We designed hybrid molecules between propamidine and benzimidazole in order to retain the antiprotozoal action, but decreasing toxic effect of molecule.Design prepare 12 hybrids for testing their antiparasitic over three protozoa: Giardia intestinalis, Trichomonas vaginalis Leishmania mexicana, as well conduct several silico simulations such toxicological profile, molecular docking dynamics understand potential mode action.Hybrids 1-3, 6-9 were obtained using a chemical pathway previously...
The stingless bee Melipona beecheii is experiencing colony decline due to floral resource scarcity caused by deforestation. A study was conducted identify the resources used M. using honey samples collected in four regions of state Campeche, Mexico. melissopalynological analysis sixteen identified 69 plant species from 24 families, and established that Fabaceae main family visited. Based on botanical origin, seven were classified as monofloral nine multifloral. predominant Bursera simaruba,...
Hepatic cirrhosis is a neglected worldwide public health problem. Current hepatic treatment drugs remain inadequate and provide poor prognosis. Research on alternative treatments has broadened to include active compounds from natural sources. Tradescantia pallida plant native Mexico with high antioxidant content the activity of which received only limited attention. The hepatoprotective ethanol extract (TPEE) was evaluated through histopathology, analysis functional biochemical parameters....
A phytochemical investigation of the stem bark Diospyros cuneata (Ebenaceae) together with in vitro cytotoxic evaluation pure compounds four human cancer cell lines KB, Hep-2, HeLa and SiHa led to isolation plumbagin, elliptinone, lupeol, atraric acid methyl ester, maritinone, betulin betulinaldehyde. The structural determination was established by nuclear magnetic resonance, electron ionisation mass spectrometric analysis as well comparison data from literature. Plumbagin exhibited a potent...
The relevance of intermolecular noncovalent Cl ··· Cu interactions in the magnetic and biological behavior copper complexes derived from amino amides is studied. Crystallography studies show that these tend to stack, favoring (hydrogen bonding Cl). However, presence substituents at C10 C13 positions regulates supramolecular structures 2 . Thus, 93, 293, 353 K demonstrate exchange favored only by Cu–Cl interactions. Moreover, those with ferromagnetic present cytotoxic activity. Natural bond...
Purpose: To prepare some 2-amino-4-(p-substituted phenyl)-oxazole derivatives and to evaluate their in vitro antiprotozoal activity against Giardia lamblia Trichomonas vaginalis.Methods: The phenyl)-oxazoles (a-g) were synthesized by microwave (MW) irradiation of mixtures p-substituted 2-bromoacetophenones urea dimethylformamide (DMF). All compounds identified 1H 13C nuclear magnetic resonance (NMR) spectroscopy lowand high-resolution mass spectrometry (HRMS). NMR assignments made based on...
Abstract We report the synthesis of arsenic heterocycles derived from saccharides 2 – 4 and AsCl 3 . Compounds 5 6 are stable in aqueous solutions, DMSO, or methanolic solutions. However, NMR HPLC studies revealed that intramolecular trans‐esterification processes leads to dynamic equilibria. Theoretical three arsenates two arsoranes participate these equilibria account for experimental spectroscopy results. Through correlation between theoretical 13 C spectra, we proposed speciation...
Abstract The Omicron subvariant BA.1 of SARS-CoV-2 was first detected in November 2021 and quickly spread worldwide, displacing the Delta variant. In Mexico, this began spreading during week December became dominant next three weeks, causing fourth COVID-19 epidemiological surge country. Unlike previous variants, did not acquire local substitutions nor exhibited a geographically distinct circulation pattern Mexico. However, regional difference speed replacement variant observed, as some...
In this study, twenty-four organic extracts from six marine sponge species, collected at shallows of Yucatan, Mexico, were evaluated against Giardia lamblia trophozoites and Vero cells. The dichloromethane hexane Haliclona tubifera exhibited the highest antigiardiasic activity (IC50 = 1.00 2.11 µg/mL, respectively), as well high selectivity (SI 41.8 > 47.4, while ethyl acetate methanol Cinachyrella alloclada, extract Suberites aurantiaca showed moderate activity. Contrastingly, Halichondria...