A5020537926- Memory and Neural Mechanisms
- Posttraumatic Stress Disorder Research
- Dementia and Cognitive Impairment Research
- Traumatic Brain Injury Research
- Cholinesterase and Neurodegenerative Diseases
- Sleep and Wakefulness Research
- Virus-based gene therapy research
- Traumatic Brain Injury and Neurovascular Disturbances
- Functional Brain Connectivity Studies
- Intensive Care Unit Cognitive Disorders
- Virology and Viral Diseases
- EEG and Brain-Computer Interfaces
- Cytomegalovirus and herpesvirus research
- Migration, Health and Trauma
- Schizophrenia research and treatment
- Respiratory viral infections research
- SARS-CoV-2 detection and testing
- Cardiac Arrest and Resuscitation
- Herpesvirus Infections and Treatments
- Resilience and Mental Health
- Ethics in Clinical Research
- Health Literacy and Information Accessibility
- Viral Infections and Outbreaks Research
- Healthcare Technology and Patient Monitoring
- Personality Disorders and Psychopathology
Boston University
2016-2024
Independent Sector
2024
VA Boston Healthcare System
2014-2021
Nova Scotia Health Authority
2015-2019
Dalhousie University
2019
Geriatric Research Education and Clinical Center
2016-2017
University of Connecticut
2007-2012
Background Post-traumatic stress disorder (PTSD) is associated with elevated risk for metabolic syndrome (MetS). However, the direction of this association not yet established, as most prior studies employed cross-sectional designs. The primary goal study was to evaluate bidirectional associations between PTSD and MetS using a longitudinal design. Method A total 1355 male female veterans conflicts in Iraq Afghanistan underwent diagnostic assessments their biometric profiles pertaining were...
An infectious bursal disease virus (IBDV) was isolated from 39-to-43-day-old commercial leghorn pullets suspected of having (IBD). These chickens had been vaccinated with a live IBDV vaccine at 28 and 35 days age. isolate designated IN recovered using specific-pathogen-free (SPF) the BGM-70 established cell line. Experimental studies SPF either inactivated vaccines made strain used in problem flock or standard-type indicated no protection against isolate. However, two variants another...
Repetitive head impacts (RHIs) from football are associated with the neurodegenerative tauopathy chronic traumatic encephalopathy (CTE). It is unclear whether a history of brain injury (TBI) sufficient to precipitate CTE neuropathology. We examined association between TBI and neuropathology in 580 deceased individuals exposed RHIs football. was assessed using modified version Ohio State University Identification Method Short Form administered informants. There were 22 donors who had no TBI,...
Abstract Objective This study examined between‐ and within‐subject stability of cognitive performance in individuals with chronic schizophrenia. Methods Thirty schizophrenia 20 healthy controls matched by age, sex, education, estimated IQ underwent repeated assessments at baseline 30 days using computerized tests psychomotor function, visual attention/information processing, non‐verbal learning, executive function. Results Compared to controls, scored lower on all measures demonstrated...
This study examined the unique and combined relationship between mild traumatic brain injury (mTBI) posttraumatic stress disorder (PTSD) with psychosocial functioning in a cohort of 1,312 U.S. male female veterans Operations Enduring Freedom (OEF) Iraqi (OIF) enrolled Veterans After-Discharge Longitudinal Registry (Project VALOR). We assessed mTBI structured screening questions reflective current TBI classification standards PTSD via SCID-IV module; all other variables were by self-report...
The BioPlex 2200 (Bio-Rad Laboratories, Hercules, CA) is a rapid, automated platform, which can screen large numbers of specimens for antibodies to measles, mumps, rubella, and varicella. Although approved producing qualitative results, in this study we validated the test (off-label) allow reporting quantitative results. To do this, used third anti-measles World Health Organization standard generate calibration curve that allowed relative fluorescence intensity be translated into antibody...
The Veterans Health Administration (VHA) has promoted the use of telehealth technologies to deliver mental health care veterans with limited access services on account geographic and other barriers. technology interventions posttraumatic stress disorder (PTSD) been a particular focus within VHA. Much less attention paid diagnose PTSD for both treatment and/or disability compensation purposes, in spite need such services. literature evaluating video teleconferencing methods assessment is...
Objective: Veterans from recent military conflicts frequently report persisting symptoms associated with concussion well beyond the expected period of recovery following mild traumatic brain injury. This study examined differences in reporting between clinical and research contexts. Methods: naturalistic comparison included 91 Operations Enduring Freedom (OEF), Iraqi (OIF) New Dawn (OND). All participants were enrolled a longitudinal focused on injury stress-related disorders had also...
Serology remains the mainstay for diagnosis of Epstein-Barr virus (EBV) infection. This study compared two automated platforms (BioPlex 2200 and Architect i2000SR) to test three EBV serological markers: viral capsid antigen (VCA) immunoglobulins class M (IgM), VCA G (IgG) nuclear antigen-1 (EBNA-1) IgG. Using sera from 65 patients at various stages disease, BioPlex demonstrated near-perfect agreement all markers a consensus reference. The was IgG EBNA-1 IgG, substantial IgM despite five...
The present study examined the effect of massed versus spaced learning trials on 24-hour delayed recall for a visuospatial task. To determine utility measuring incremental benefit training as cognitive assay that may be useful in early clinical trials, we used within-subject crossover design, with two small samples (typical sample sizes phase I trials). Young adults and cognitively healthy older without significant physical, neurological, or psychiatric illness were trained paired-associate...
Most commercially available enzyme immunoassay-based methods have limited sensitivity to detect antibody responses varicella-zoster virus (VZV) in vaccinated individuals, who produce lower levels than those with natural infection. However, more sensitive are either not or less amenable high-throughput testing.
Abstract The Clinician‐Administered PTSD Scale (CAPS) is used to measure posttraumatic stress symptoms (PTSS) and diagnose disorder (PTSD). However, its use, particularly in settings involving longitudinal assessment, has been complicated by changes the diagnostic criteria between fourth fifth editions of Diagnostic Statistical Manual Mental Disorders (i.e., DSM‐IV DSM‐5 , respectively). current sample included trauma‐exposed U.S. veterans who were deployed support military operations...
Cross-sectional research suggests that posttraumatic stress symptoms (PTSS) among war zone veterans are associated with functional impairment and poor quality of life. Less is known about the long-term repercussions PTSS. This study Iraq War examined associations between increases in PTSS outcomes, including potential contributions neurocognitive decrements. Service members (N = 594) completed self-report measures functioning severity before deployment again after their return (M 9.3 years...
Background With the recent outbreak in West Africa, hospitals worldwide have been developing protocols for suspect of cases Ebola virus disease. Patients with disease present a severe gastroenteritis leading to dehydration and electrolyte abnormalities as such, routine chemistry analysis is essential patient management. While point-of-care testing can be used additional precautions rapid analyses laboratory setting, significant delays could ensue before specimens arrive laboratory. This...
Purpose: Cognitive screening upon hospital admission can provide important information about the patient’s ability to process during inpatient stay. The Clock-in-the-Box (CIB) is a rapidly administered cognitive measure which has been previously validated with and neuropsychological assessments. purpose of this study demonstrate predictive validity CIB for discharge location among sample older medical inpatients. Patients methods: Hospitalized Veterans (N=218), aged 55 years older, were...
Objectives Rates of post-traumatic stress disorder (PTSD) among older adults range from 0.4%–4.5%. Research examining PTSD in has demonstrated numerous associations between physical and mental health conditions; however, these are less well characterized adults. The current study aimed to identify base rates such conditions with without a history PTSD. Method In case control design using the National Alzheimer’s Coordinating Center Uniform Data Set, 65 years or United States who endorsed...
Interprofessional healthcare teams are increasingly viewed as a clinical approach to meet the complex medical, psychological, and psychosocial needs of older adult patients. Despite fact that adults at risk for cognitive difficulties, neuropsychologists not routinely included on Geriatrics consult teams. The primary aim this paper is highlight utility neuropsychology within an interprofessional clinic. To address aim, we describe specific benefits patient care may be associated with...
The deliberate inhalation of petrol as a means intoxication used by underage and marginalized social groups is growing international problem. This type abuse has been identified the cause severe physical, cognitive, psychological impairment. Both these factors have heightened need for identifying causes underlying why individuals begin abusing petrol. One hundred Australian male adults were surveyed while they filling their cars with While exposed to ambient petrol, asked rate how pleasant...
Abstract Given the unprecedented demand for SARS-CoV-2 testing during COVID-19 pandemic, benefits of specimen pooling have recently been explored. As previous studies were limited to mathematical modeling or on low throughput PCR instruments, this study aimed assess high analyzers. To impact pooling, dilutions performed at varying pool depths (i.e. 1:2, 1:4, and 1:8) into test-negative nasopharyngeal oropharynx/anterior nares swabs matrix. Testing was evaluated automated Roche Cobas 6800...