A5067701205- Immunotoxicology and immune responses
- Carcinogens and Genotoxicity Assessment
- Molecular Biology Techniques and Applications
- Lymphoma Diagnosis and Treatment
- Adipose Tissue and Metabolism
- Effects and risks of endocrine disrupting chemicals
- Cancer and biochemical research
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Veterinary Pharmacology and Anesthesia
- DNA Repair Mechanisms
- Turtle Biology and Conservation
- Regulation of Appetite and Obesity
- Pancreatic function and diabetes
- Monoclonal and Polyclonal Antibodies Research
- Pancreatic and Hepatic Oncology Research
- Air Quality and Health Impacts
- Kruppel-like factors research
- Liver physiology and pathology
- Reliability and Agreement in Measurement
- Cancer Cells and Metastasis
- Heavy Metal Exposure and Toxicity
- Toxic Organic Pollutants Impact
- Chronic Lymphocytic Leukemia Research
- Nanoparticles: synthesis and applications
Research Triangle Park Foundation
2024
Triangle
2009-2021
Integrated Laboratory Systems, Inc.
2008-2020
North Carolina State University
2003-2008
Tris(Chloropropyl) phosphate (TCPP) is a member of organophosphate flame retardants (OPFRs) used commonly as replacement for polybrominated diphenyl ethers in consumer and commercial products. Flame have been shown to modulate immune function vivo vitro there evidence that at least some related compounds such pesticides can cause developmental immunotoxicity. Developmental immunotoxicology studies were conducted by administering 0, 2500, 5000 or 10000 ppm TCPP feed pregnant Hsd: Sprague...
Rodent progressive cardiomyopathy (PCM) encompasses a constellation of microscopic findings commonly seen as spontaneous background change in rat and mouse hearts. Primary histologic features PCM include varying degrees cardiomyocyte degeneration/necrosis, mononuclear cell infiltration, fibrosis. Mineralization can also occur. Cardiotoxicity may increase the incidence severity PCM, toxicity-related morphologic changes overlap with those PCM. Consequently, sensitive consistent detection...
Small fish models have been used for decades in carcinogenicity testing. Demonstration of common morphological changes associated with specific mechanisms is a clear avenue by which data can be compared across divergent phyletic levels. Dimethylnitrosamine, rats to model human alcoholic cirrhosis and hepatic neoplasia, also potent hepatotoxin carcinogen fish. We recently reported some striking differences the mutagenicity DMN lambda cII transgenic medaka vs. Big Blue(®) rats, but...
The National Toxicology Program (NTP) has recently introduced the practice of examining longitudinal histological sections female rodent uterus to improve identification non-neoplastic lesions, preneoplastic and uterine tumors. This created a need for reference material that includes normal histology, spontaneous inducible lesions in as well transverse body uterus, horns, cervix vagina. Using 3 archived NTP reproductive developmental toxicity studies, authors reviewed uteri from Hsd:Sprague...
We previously developed a computer-assisted image analysis algorithm to detect and quantify the microscopic features of rodent progressive cardiomyopathy (PCM) in rat heart histologic sections validated results with panel five veterinary toxicologic pathologists using multinomial logistic model. In this study, we assessed both inter-rater intra-rater agreement compared pathologists' ratings artificial intelligence (AI)-predicted scores. Pathologists AI were presented 500 slides heart. They...
Abstract Welding fumes are a Group 1 (carcinogenic to humans) carcinogen as classified by the International Agency for Research on Cancer. The process of welding creates inhalable rich in iron (Fe) that may also contain known carcinogenic metals such chromium (Cr) and nickel (Ni). Epidemiological evidence has shown both mild steel (Fe-rich) stainless (Fe-rich + Cr Ni) fume exposure increases lung cancer risk, experimental animal data support these findings. Copper-nickel (CuNi) processes...
The 2024 annual Division of Translational Toxicology (DTT) Satellite Symposium, entitled "Pathology Potpourri," was held in Baltimore, Maryland, at the Society Toxicologic Pathology's 42nd meeting. goal this symposium to present and discuss challenging diagnostic pathology and/or nomenclature issues. This article presents summaries speakers' talks along with select images that were used by audience for voting discussion. Various lesions topics covered during included induced nonneoplastic...
ABSTRACT A captive-raised, 4-year-old male African spurred tortoise, Geochelone sulcata, was maintained in an indoor/outdoor enclosure and found dead after a two-day history of polyuria. Gross necropsy revealed severe oral mucosal esophageal ulceration intestinal tract diffusely packed with oak leaves. Histologically, there fibrinonecrotic stomatitis, glossitis, segmental enteritis, necrotizing splenitis, multifocal intravascular thrombosis, renal tubular nephrosis. The nephrosis were...
Abstract Our previous work showed that AID-deficient MRL/lpr (AID-/-) mice which had high levels of autoreactive IgM experienced a longer lifespan than muS-/-AID-/-MRL/lpr (muS-/-) whose B cells did not secrete any antibodies. Histology results indicated these died Lymphoma/lymphocytic leukemia (LLL). Further studies at 6 months age, all muS-/- developed LLL, while only 24% AID-/- LLL. At 12 eventually the from both strains but LLL grade was higher (P = 0.004). When bone marrow were...
MRL/lpr mice typically succumb to immune complex-mediated nephritis within the first year of life. However, that only secrete IgM Abs because activation-induced deaminase deficiency (AID-/-MRL/lpr mice) experienced a dramatic increase in survival. Further crossing these those incapable making secretory (μS generated lacking any secreted but with normal B cell receptors. Both strains revealed no kidney pathology, yet Ab-deficient still high mortality. In this article, we report progressed...