A5012181087- Craniofacial Disorders and Treatments
- Cleft Lip and Palate Research
- Orthopaedic implants and arthroplasty
- Total Knee Arthroplasty Outcomes
- Orthopedic Infections and Treatments
- dental development and anomalies
- Bone fractures and treatments
- Amphibian and Reptile Biology
- Facial Trauma and Fracture Management
- Prosthetics and Rehabilitation Robotics
- Morphological variations and asymmetry
- Animal Behavior and Reproduction
- Evolution and Paleontology Studies
- Lower Extremity Biomechanics and Pathologies
- Turtle Biology and Conservation
- Orthopedic Surgery and Rehabilitation
- Muscle activation and electromyography studies
- Knee injuries and reconstruction techniques
- Paleontology and Evolutionary Biology
- Bone Tissue Engineering Materials
- Hip and Femur Fractures
- Soft Robotics and Applications
- Forensic Anthropology and Bioarchaeology Studies
- Cellular Mechanics and Interactions
- Robot Manipulation and Learning
University College London
2015-2024
Stanmore College
2019
University of Leeds
2009-2018
University of Hull
2008-2015
Hull York Medical School
2008-2015
Stress shielding secondary to bone resorption is one of the main causes aseptic loosening, which limits lifespan hip prostheses and exacerbates revision surgery rates. In order minimise post-hip replacement stress variations, this investigation proposes a low-stiffness, porous Ti6Al4V prosthesis, developed through selective laser melting (SLM). The effect potential properties implant were investigated both in vitro quasi-physiological experimental assays, together with finite element...
Additive manufacturing has been used to develop a variety of scaffold designs for clinical and industrial applications. Mechanical properties (i.e., compression, tension, bending, torsion response) these scaffolds are significantly important load-bearing orthopaedic implants. In this study, we designed additively manufactured porous metallic biomaterials based on two different types triply periodic minimal surface structures gyroid diamond) that mimic the mechanical bone, such as porosity,...
Knowledge of human craniofacial growth (increase in size) and development (change shape) is important the clinical treatment a range conditions that affects it. This study uses an extensive collection CT scans to investigate over first 48 months life, detail how cranium changes form (size each sex these are associated with various soft tissues such as brain, eyes tongue expansion nasal cavity. achieved through multivariate analyses cranial based on 3D landmarks semi-landmarks by linear...
Abstract Osteoderms (ODs) are mineralized tissue embedded within the skin and particularly common in reptiles. They generally thought to form a protective layer between soft tissues of animal potential external threats, although other functions have been proposed. The aim this study was characterize OD variation across lizard body. Adults three species were chosen for study. After whole body CT scanning each lizard, single ODs extracted from 10 different anatomical regions, scanned,...
Sutures form an integral part of the functioning skull, but their role has long been debated among vertebrate morphologists and palaeontologists. Furthermore, relationship between typical skull sutures, those involved in cranial kinesis, is poorly understood. In a series computational modelling studies, complex loading conditions obtained through multibody dynamics analysis were imposed on finite element model Uromastyx hardwickii , akinetic herbivorous lizard. A (FEA) with no sutures...
During the first year of life, brain grows rapidly and neurocranium increases to about 65% its adult size. Our understanding relationship between biomechanical forces, especially from growing brain, craniofacial soft tissue structures individual bone plates skull vault is still limited. This basic knowledge could help in future planning surgical operations. The aim this study was develop a validated computational model growth, based on finite-element (FE) method, understand biomechanics...
Abstract Evaluating stress and strain fields in anatomical structures is a way to test hypotheses that relate specific features of facial skeletal morphology mechanical loading. Engineering techniques such as finite element analysis are now commonly used calculate fields, but if we fully accept these methods must be confident the applied loading regimens reasonable. Multibody dynamics (MDA) relatively new three dimensional computer modeling technique can apply varying muscle forces predict...
The lepidosaurian skull has long been of interest to functional morphologists and evolutionary biologists. Patterns bone loss gain, particularly in relation bars fenestrae, have led a variety hypotheses concerning use kinesis. Of these, one the most enduring relates absence lower temporal bar squamates acquisition streptostyly. We performed series computer modeling studies on Uromastyx hardwickii, an akinetic herbivorous lizard. Multibody dynamic analysis (MDA) was conducted predict forces...
Polyether-ether-ketone (PEEK) is widely used in producing prosthesis and have gained great attention for repair of large bone defect recent years with the development additive manufacturing. This due to its excellent biocompatibility, good heat chemical stability similar mechanical properties which mimics natural bone. In this study, three replicates rectilinear scaffolds were designed compression, tension, three-point bending torsion test unit cell size 0.8 mm, a pore 0.4 strut thickness mm...
Abstract X‐ray Computed Tomography (CT) images are widely used in various fields of natural, physical, and biological sciences. 3D reconstruction the involves segmentation structures interest. Manual has been field sciences for complex composed several sub‐parts can be a time‐consuming process. Many tools have developed to automate process, all with limitations advantages, however, multipart remains largely manual The aim this study was develop an open‐access user‐friendly tool automatic...
The morphology and biomechanics of infant crania undergo significant changes between the pre- post-weaning phases due to increasing loading masticatory system. aims this study were characterize in muscle forces, bite forces pattern mechanical strain stress arising from aforementioned across first 48 months life using imaging finite element methods. A total 51 head computed tomography scans normal individuals collected analysed a larger database 217 individuals. estimated mean temporalis,...
In x-ray phase contrast imaging (XPCI) using the edge illumination method (EI), crosstalk (XT) between adjacent pixels due to, e.g., light diffusion in scintillator indirect conversion detector systems is an issue that blurs images and reduces both image sharpness quantitative accuracy. We provide a detailed mathematical description of this phenomenon propose two independent methods to mitigate its negative effects. The effectiveness these techniques demonstrated through simulated...
Lizard skulls vary greatly in shape and construction, radical changes skull form during evolution have made this an intriguing subject of research. The mechanics feeding surely been affected by change form, but whether is the driving force behind underlying question that we are aiming to address a programme Here implemented combined finite element analysis (FEA) multibody dynamics (MDA) assess biomechanics biting. A Uromastyx hardwickii was assessed present study, where loading data (such as...
Increasingly, the rat femoral fracture model is being used for preclinical investigations of healing, however, effect gap size and its influence on mechanobiology not well understood. We aimed to evaluate osteotomy healing between previously published extremes guaranteed union (0.5 mm) non-union (3 using this model. A in 12-14 week old female Wistar rats was stabilised with a micro fixator (titanium blocks, carbon fiber bars) an 1.0 mm (n = 5), 1.5 7), 2.0 6). After five weeks, left femur...
Abstract Early fusion of the sagittal suture is a clinical condition called, craniosynostosis. Calvarial reconstruction most common treatment option for this with range techniques being developed by different groups. Computer simulations have huge potential to predict calvarial growth and optimise management condition. However, these models need be validated. The aim study was develop validated patient-specific finite element model Here, method used morphology patient based on its...
Abstract We describe the histological appearance of osteoderms (ODs) Heloderma suspectum and Varanus komodoensis using multiple staining microscopy techniques to yield information about their morphology development. Histological analysis showed that ODs H. are composed three main tissue types, a superficial layer, herein identified as osteodermine, capping base Sharpey‐fibre bone lamellar rich in secondary osteons (Haversian tissue). In contrast, V. core woven surrounded by parallel‐fibred...
Partial hand amputations are common in developing countries and have a negative impact on patients their families' quality of life. The uniqueness each partial amputation, coupled with the relatively high costs prostheses, makes it challenging to provide suitable prosthetic solutions countries. Current often long lead times require level expertise produce. aim this study was design develop an affordable patient-specific prosthesis for countries.The designed patient transmetacarpal amputation...
Additively manufactured Ti scaffolds have been used for bone replacement and orthopaedic applications. In these applications, both morphological mechanical properties are important their in vivo performance. Ti6Al4V triply periodic minimal surface (TPMS) with diamond gyroid structures known to high stiffness osseointegration properties, respectively. However, deviations between the as-designed as-built types of not studied before. this study, at macro microscales were examined. The results...