A5080824438- DNA Repair Mechanisms
- Ubiquitin and proteasome pathways
- BRCA gene mutations in cancer
- Heat shock proteins research
- CRISPR and Genetic Engineering
- DNA and Biological Computing
- Click Chemistry and Applications
- Microtubule and mitosis dynamics
- Toxin Mechanisms and Immunotoxins
- Cancer Genomics and Diagnostics
- Cancer-related Molecular Pathways
- RNA regulation and disease
- Water-Energy-Food Nexus Studies
- Genetics and Neurodevelopmental Disorders
- Viral Infectious Diseases and Gene Expression in Insects
- Estrogen and related hormone effects
- Peptidase Inhibition and Analysis
- Genomics and Chromatin Dynamics
- Hormonal Regulation and Hypertension
- Molecular Biology Techniques and Applications
- Hippo pathway signaling and YAP/TAZ
- Anodic Oxide Films and Nanostructures
- Immune Cell Function and Interaction
- Protein Degradation and Inhibitors
Woomera Therapeutics
2024
Novartis (United States)
2022
The University of Texas MD Anderson Cancer Center
2012-2017
The University of Texas Health Science Center at Houston
2017
The University of Texas at Austin
2014
The University of Texas at El Paso
2010
Developing therapies for the activated B-cell like (ABC) subtype of diffuse large lymphomas (DLBCL) remains an area unmet medical need. A subset ABC DLBCL tumors is driven by activating mutations in myeloid differentiation primary response protein 88 (MYD88), which lead to constitutive activation interleukin-1 receptor associated kinase 4 (IRAK4) and cellular proliferation. IRAK4 signaling its catalytic scaffolding functions, necessitating complete removal this escape mechanisms therapeutic...
BRCA1 accumulation at DNA damage sites is an important step for its function in the response and repair. BRCA1-BRCT domains bind to proteins containing phosphorylated serine-proline-x-phenylalanine (pSPxF) motif including Abraxas, Bach1/FancJ, CtIP. In this study, we demonstrate that ionizing radiation (IR)-induces ATM-dependent phosphorylation of serine 404 (S404) next pSPxF motif. Crystal structures BRCT/Abraxas show S404 extensive interactions through N-terminal sequence outside leads...
Protection of the stalled replication fork is crucial for responding to stress and minimizing its impact on chromosome instability, thus preventing diseases, including cancer. We found a new component, Abro1, in protection integrity. Abro1 deficiency results increased Abro1-null mice are tumor-prone. show that protects stability by inhibiting DNA2 nuclease/WRN helicase-mediated degradation forks. Depletion RAD51 prevents DNA2/WRN-dependent forks Abro1-deficient cells. This mechanism distinct...
The Hippo/YAP pathway controls cell proliferation through sensing physical and spatial organization of cells. How cell-cell contact is sensed by Hippo signaling poorly understood. Here, we identified the adhesion molecule KIRREL1 as an upstream positive regulator mammalian pathway. physically interacts with SAV1 recruits to sites. Consistent hypothesis that KIRREL1-mediated suppresses YAP activity, knockout increases activity in neighboring Analyzing pan-cancer CRISPR screen data reveals top...
Germline mutations of BRCA1 confer hereditary susceptibility to breast and ovarian cancer. However, somatic mutation is infrequent in sporadic cancers. The protein C terminus (BRCT) domains interact with multiple proteins are required for BRCA1's tumor-suppressor function. In this study, we demonstrated that Abraxas, a BRCT domain-interacting protein, plays role tumor suppression. Abraxas exerts its function through binding regulate DNA repair maintain genome stability. Both homozygous...
Steroid hormone receptors are ligand-dependent transcription factors that require the ordered assembly of multichaperone complexes for transcriptional activity. Although heat shock protein (Hsp) 90 and Hsp70 key players in this process, multiple Hsp70- Hsp90-associated cochaperones associate with receptor-chaperone to regulate receptor folding activation. Small glutamine-rich tetratricopeptide repeat-containing alpha (SGTA) was recently characterized as an cochaperone specifically regulates...