Two new alkylamine-substituted nickel(II)−salphen complexes have been prepared and their interactions with DNA investigated. FRET studies shown that these a remarkable ability to stabilize G-quadruplex DNA. Furthermore, TRAP/Taq assays inhibit telomerase at low micromolar concentrations.

Artificial intelligence (AI) for healthcare presents potential solutions to some of the challenges faced by health systems around world. However, it is well established in implementation and innovation research that novel technologies are often resisted leaders, which contributes their slow variable uptake. Although on various stakeholders' perspectives AI has been undertaken, very few studies have investigated leaders' issue healthcare. It essential understand because they a key role...

Background Significant efforts have been made to develop artificial intelligence (AI) solutions for health care improvement. Despite the enthusiasm, professionals still struggle implement AI in their daily practice. Objective This paper aims identify implementation frameworks used understand application of Methods A scoping review was conducted using Cochrane, Evidence Based Medicine Reviews, Embase, MEDLINE, and PsycINFO databases publications that reported frameworks, models, theories...

Ensuring patients benefit from the latest medical and technical advances remains a major challenge, with rational-linear reductionist approaches to translating evidence into practice proving inefficient ineffective. Complexity thinking, which emphasises interconnectedness unpredictability, offers insights inform translation theories strategies. Drawing on detailed complex micro-systems, this research aimed advance empirical theoretical understanding of reality making sustaining improvements...

Although policy discourses frame integrated Electronic Health Records (EHRs) as essential for contemporary healthcare systems, increased information sharing often raises concerns among patients and the public. This paper examines patient public views about security privacy of EHRs used health provision, research in UK. Sequential mixed methods study with a cross-sectional survey (in 2011) followed by focus group discussions 2012-2013). Survey participants (N = 5331) were recruited from...

Introduction Process mapping provides insight into systems and processes in which improvement interventions are introduced is seen as useful healthcare quality projects. There little empirical evidence on the use of process practice. This study advances understanding benefits success factors within Methods Eight projects were purposively selected from different settings UK’s National Health Service. Data gathered multiple data-sources, including interviews exploring participants’ experience...

Research on organizational interventions needs to meet the objectives of both researchers and participating organizations. This duality means that real-world impact has be considered throughout research process, simultaneously addressing scientific rigour practical relevance. discussion paper aims offer a set principles, grounded in knowledge from various disciplines can guide designing, implementing, evaluating interventions. Inspired by Mode 2 production, principles were developed through...

The development of Electronic Health Records (EHRs) forms an integral part the information strategy for National Service (NHS) in UK, with aim facilitating health exchange patient care and secondary use, including research healthcare planning. Implementing EHR systems requires understanding expectations consent mechanisms consideration public awareness towards sharing as might be made possible through integrated EHRs across primary providers.To explore levels about to examine attitudes...

Two new mono-substituted phenanthroline ligands and their platinum(II) square planar complexes have been prepared; one of the has shown to induce a high degree quadruplex DNA stabilisation inhibit telomerase.

Background The identification and articulation of programme theory can support effective design, execution evaluation quality improvement (QI) initiatives. Programme includes an agreed aim, potential interventions to achieve this anticipated cause/effect relationships between the aim measures monitor improvement. This paper outlines approach used in a research QI initiatives identifying articulating theory: action effect method. method development Building on previously method, driver...

Background: The development and implementation of electronic health records (EHRs) remains an international challenge. Better understanding patient public attitudes the factors that influence overall levels support toward EHRs is needed to inform policy. Objective: To explore integrated used simultaneously for care provision, planning policy, research. Methods: Cross-sectional questionnaire survey administered patients members who were recruited from a stratified cluster random sample 8...

Background Although widely recommended as an effective approach to quality improvement (QI), the Plan–Do–Study–Act (PDSA) cycle method can be challenging use, and low fidelity of published accounts has been reported. There is little evidence on PDSA cycles used by front-line teams, nor how support improve method’s use. Data collected from 39 teams provided opportunity retrospectively investigate use strategies were modified help this over time. Methods The 421 was reviewed using a predefined...

The uptake of artificial intelligence (AI) in health care is at an early stage. Recent studies have shown a lack AI-specific implementation theories, models, or frameworks that could provide guidance for how to translate the potential AI into daily practices. This protocol provides outline first 5 years research program seeking address this knowledge-practice gap through collaboration and co-design between researchers, professionals, patients, industry stakeholders.The part focuses on two...

During the Salzburg Global Seminar Session 565-'Better Health Care: How do we learn about improvement?', participants discussed need to unpack 'black box' of improvement. The refers fact that when quality improvement interventions are described or evaluated, there is a tendency assume simple, linear path between intervention and outcomes it yields. It also assumed enough evaluate results without understanding process by which took place. However, complex, nonlinear evolve in response local...

The importance of contextual factors in influencing quality improvement and implementation (QI&I) initiatives is broadly acknowledged. Existing treatments context have primarily viewed it as static distinct from interventions themselves. objective this study was to advance understanding the complex dynamic interaction between context, intervention, strategies. Using Model for Understanding Success Quality (MUSIQ), we aimed better understand roles of, inter-relationships between, within QI&I...

Evidence translation and improvement research indicate that healthcare contexts are complex systems, characterized by uncertainty surprise, which often defy orchestrated intervention attempts. This article reflects on the implications of complexity attempts to translate evidence, a newly published framework for Successful Healthcare Improvements From Translating in systems (SHIFT-Evidence).SHIFT-Evidence positions challenge evidence within evolving context healthcare, recognizes wider issues...

A series of new mono-carboxamido phenanthrolines and bis-carboxamido pyridines have been prepared their coordination chemistry to platinum(II) palladium(II) investigated. Both the ligands metal complexes designed with appropriate geometric requirements favour π–π interactions guanine quartets, which are core motif in quadruplex structures formed by folding single-stranded telomeric DNA. The these compounds quadruplex-DNA results show that some induce stabilisation (e.g. ΔTm at 1 μM 20 °C for...