A5018597209- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- DNA and Nucleic Acid Chemistry
- Advanced biosensing and bioanalysis techniques
- RNA Interference and Gene Delivery
- Metal complexes synthesis and properties
- Molecular Sensors and Ion Detection
- Crystallography and molecular interactions
- Organometallic Complex Synthesis and Catalysis
- Supramolecular Chemistry and Complexes
- Catalytic Cross-Coupling Reactions
- Magnetism in coordination complexes
- Metal-Organic Frameworks: Synthesis and Applications
- RNA and protein synthesis mechanisms
- Asymmetric Hydrogenation and Catalysis
- Chemical Synthesis and Analysis
- Catalytic C–H Functionalization Methods
- Trace Elements in Health
- Ferrocene Chemistry and Applications
- Medical Imaging Techniques and Applications
- Radiopharmaceutical Chemistry and Applications
- Arsenic contamination and mitigation
- Lanthanide and Transition Metal Complexes
- Innovative Microfluidic and Catalytic Techniques Innovation
- Nanocluster Synthesis and Applications
Imperial College London
2016-2025
Transnational Press London
2016-2021
The London College
2011-2013
TU Dortmund University
2013
Instituto de Síntesis Química y Catálisis Homogénea
2013
Universidad de Zaragoza
2013
ETH Zurich
2012
Institut Català d'Investigació Química
2004-2009
Universitat Autònoma de Barcelona
2006
University of York
2006
Abstract Palladium‐mediated cross‐coupling reactions are attractive organometallic transformations for the generation of CC, CN, CO, and CS bonds. Despite being widely employed in small‐scale syntheses, have not found important industrial applications because until recently, only reactive aryl bromides iodides could be used as substrates. These substrates generally more expensive less available than their chloride counterparts. Over past few years, new catalytic systems with ability to...
Two new alkylamine-substituted nickel(II)−salphen complexes have been prepared and their interactions with DNA investigated. FRET studies shown that these a remarkable ability to stabilize G-quadruplex DNA. Furthermore, TRAP/Taq assays inhibit telomerase at low micromolar concentrations.
Abstract Guanine-rich oligonucleotides can fold into quadruple-stranded helical structures known as G-quadruplexes. Mounting experimental evidence has gathered suggesting that these non-canonical nucleic acid form in vivo and play essential biological roles. However, to date, there are no small-molecule optical probes image G-quadruplexes live cells. Herein, we report the design development of a small fluorescent molecule, which be used an probe for We demonstrate fluorescence lifetime this...
Guanine rich regions of oligonucleotides fold into quadruple-stranded structures called G-quadruplexes (G4s). Increasing evidence suggests that these G4 form in vivo and play a crucial role cellular processes. However, their direct observation live cells remains challenge. Here we demonstrate fluorescent probe (DAOTA-M2) conjunction with fluorescence lifetime imaging microscopy (FLIM) can identify G4s within nuclei fixed cells. We present FLIM-based assay to study the interaction...
Abstract In contrast to the well‐studied templating properties of cationic and neutral species there are relatively few examples anion‐templated syntheses. This is attributed some intrinsic anions such as their diffuse nature, pH sensitivity, relative high solvation free energies. However, increasing number assemblies reported over past years demonstrates that these limitations not critical first thought. review summarizes most important results on use directing agents for syntheses a wide...
The selectivity and sensitivity of two colorimetric sensors based on the ruthenium complexes N719 [bis(2,2'-bipyridyl-4,4'-dicarboxylate)ruthenium(II) bis(tetrabutylammonium) bis(thiocyanate)] N749 [(2,2':6',2' '-terpyridine-4,4',4' '-tricarboxylate)ruthenium(II) tris(tetrabutylammonium) tris(isothiocyanate)] are described. It was found that mercury ions coordinate reversibly to sulfur atom dyes' NCS groups. This interaction induces a color change in dyes at submicromolar concentrations...
A templating anion is a must for the formation of cage compounds [Ag14(C≡CtBu)12X]OH (X=Cl, Br), in which rhombic dodecahedron silver atoms surrounds central X atom (see picture). The are held together by combination bridging alkynyl groups (not shown) and argentophilic Ag⋅⋅⋅Ag interactions. In absence insoluble polymeric materials obtained.
The tumour suppressor phosphatase and tensin homologue deleted on chromosome 10 (PTEN) shares homology with protein tyrosine phosphatases (PTPases). Similarly, bisperoxovanadium (bpV) molecules that are well‐established PTPase inhibitors were shown to inhibit PTEN, but at up 100‐fold lower concentrations. preference potency of the bpVs towards PTEN was validated in vivo as demonstrated by: (i) an increase Ser473 phosphorylation kinase B (PKB) similar low nanomolar doses, (ii) lack any effect...
The first X-ray crystal structures of nickel(II) and copper(II) salphen metal complexes bound to a quadruplex DNA are presented. Two have been determined show that these salphen-metal bind human telomeric quadruplexes by end-stacking, with the in each case almost line potassium ion channel. Quadruplex duplex binding is presented for two other related complexes, all side-chains terminating pyrrolidino end-groups differing patterns substitution on core. able provide rationalizations...
The synthesis of two new azo phenyl thiourea compounds and their optical response to different anions is reported herein. Solution studies in methanol indicate that cyanide induces a colour change these dyes (whereas no changes are observed the presence other anions, such as F(-), Cl(-), Br(-), CH(3)COO(-), H(2)PO(4) (-), HSO(4) (-)). Interestingly, DMSO responsive not only cyanide, but also fluoride, acetate dihydrogen phosphate. Each change. In second part paper, we report attachment one...
Abstract Die Positronenemissionstomographie (PET) ist eine leistungsfähige Bildgebungsmethode, die zur Untersuchung und Visualisierung der menschlichen Physiologie eingesetzt wird. Das Funktionsprinzip PET beruht auf Detektion positronenemittierender Radiopharmazeutika. Aus PET‐Experimenten können direkte Informationen über Stoffwechselvorgänge, Rezeptor‐Enzym‐Funktionen biochemische Mechanismen im lebenden Gewebe erhalten werden. Anders als Magnetresonanztomographie (MRT)...
Copper is an essential trace element in living organisms with its levels and localisation being carefully managed by the cellular machinery. However, if misregulated, deficiency or excess of copper ions can lead to several diseases. Therefore, it important have reliable methods detect, monitor visualise this metal cells. Herein we report a new optical probe based on BODIPY, which shows switch-on fluorescence intensity upon binding copper(I), but not presence high concentration other...
The discovery of new compounds with pharmacological properties is usually a lengthy, laborious and expensive process. Thus, there increasing interest in developing workflows that allow for the rapid synthesis evaluation libraries aim identifying leads further drug development. Herein, we apply combinatorial to build library 90 iridium(III) complexes (81 which are new) over two synthesise-and-test cycles, potential agents photodynamic therapy. We demonstrate power this approach by highly...
Abstract The development of high-resolution microscopes has made it possible to investigate cellular processes in 3D and over time. However, observing fast dynamics remains challenging because photobleaching phototoxicity. Here we report the implementation two content-aware frame interpolation (CAFI) deep learning networks, Zooming SlowMo Depth-Aware Video Frame Interpolation, that are highly suited for accurately predicting images between image pairs, therefore improving temporal resolution...
Abstract Palladiumvermittelte Kreuzkupplungen sind nützliche metallorganische Transformationen zur Knüpfung von C‐C‐, C‐N‐, C‐O‐ und C‐S‐Bindungen. Obgleich sie bei Laborsynthesen häufig eingesetzt werden, haben keine bedeutende industrielle Anwendung gefunden, denn bis vor kurzem waren nur Verfahren für die reaktiven Arylbromide ‐iodide bekannt, teurer weniger leicht erhältlich als entsprechenden Arylchloride. In den letzten Jahren wurden neue Katalysatoren entwickelt, auch reaktive...
An anion is encapsulated in the center of new cage compound [Ni6 (atu)8 X]X3 (X=Cl-for structure see picture-or Br; Hatu=amidinothiourea). A combination Lewis acid-base and hydrogen-bonding interactions cause square-planar [Ni(Hatu)2 ]2+ units, after deprotonation, to assemble form this compound. remarkable feature dependence formation; nitrate, acetate, perchlorate are unsuitable as templates.
An anion is encapsulated in the center of new cage compound [Ni6 (atu)8 X]X3 (X=Cl-for structure see picture-or Br; Hatu=amidinothiourea). A combination Lewis acid-base and hydrogen-bonding interactions cause square-planar [Ni(Hatu)2 ]2+ units, after deprotonation, to assemble form this compound. remarkable feature dependence formation; nitrate, acetate, perchlorate are unsuitable as templates.
A series of new palladium dinuclear species with general formula [Pd2X(μ-X){μ- PtBu2(Bph-R)}] (X = Cl, Br; Bph biphenyl; R H, Me, NMe2) have been prepared. The two centers in these are bridged by one the aromatic rings biphenyl group present corresponding phosphine. X-ray crystal structure complexes has obtained, providing a clear picture bonding pattern. stability dimers solution is shown to be highly dependent on nature phosphine and also bridging halide. When NMe2, dissociate, yielding...
Phosphatase and tensin homologue deleted on chromosome 10 (PTEN), a phosphoinositide 3-phosphatase, is an important regulator of insulin-dependent signaling. The loss or impairment PTEN results in antidiabetic impact, which led to the suggestion that could be target for drugs against type II diabetes. Here we report design validation small- molecule inhibitor PTEN. Compared with other cysteine-based phosphatases, has much wider active site cleft enabling it bind PtdIns(3,4,5)P3 substrate. We...