A5001232357- Adipokines, Inflammation, and Metabolic Diseases
- Cardiac Valve Diseases and Treatments
- Pulmonary Hypertension Research and Treatments
- Adipose Tissue and Metabolism
- Cardiovascular Disease and Adiposity
- Cardiac Fibrosis and Remodeling
- Connective tissue disorders research
- Cardiac Imaging and Diagnostics
- Atherosclerosis and Cardiovascular Diseases
- Thermoregulation and physiological responses
- Diabetes and associated disorders
- Aortic Disease and Treatment Approaches
- Lipid metabolism and disorders
- Vestibular and auditory disorders
- Infective Endocarditis Diagnosis and Management
- Galectins and Cancer Biology
- Fibroblast Growth Factor Research
- Cardiovascular Function and Risk Factors
- Migraine and Headache Studies
- Heart Rate Variability and Autonomic Control
- Kawasaki Disease and Coronary Complications
- Orthopaedic implants and arthroplasty
- Infrared Thermography in Medicine
- Occupational Health and Performance
- Pneumonia and Respiratory Infections
Riga Stradiņš University
2006-2022
Riga East University Hospital
2019
University of Latvia
2009
Pauls Stradiņš Clinical University Hospital
2009
Paracelsus Medical University
2006
Christian Doppler Klinik
2005
The associations of the adiponectin (APM1) gene with parameters metabolic syndrome are inconsistent. We performed a systematic investigation based on fine-mapped single nucleotide polymorphisms (SNPs) highlighting genetic architecture and their role in modulating plasma concentrations particularly healthy population 1,727 Caucasians avoiding secondary effects from disease processes. Genotyping 53 SNPs (average spacing 0.7 kb) APM1 region 81 revealed two-block linkage disequilibrium (LD)...
Background and Purpose— Adipose tissue produces secretes a number of bioactive molecules, conceptualized as adipocytokines. Adiponectin has been identified one the adipocytokines, hypoadiponectinemia was demonstrated in patients with obesity, diabetes mellitus, coronary artery disease. Whether decreased adiponectin levels are cause or consequence is an important issue discussion on association between atherosclerosis. In present study, we investigated plasma sonographic phenotypes...
Background and objectives: Mechanical stress is currently considered as the main factor promoting calcific aortic valve stenosis (AS) onset. It causes endothelial damage dysfunction. The chronic inflammatory process oxidative stress. Oxidative stress-induced high-density lipoprotein cholesterol (HDL-C) dysfunction an important component of development AS. aim study was to evaluate role HDL-C in AS patients three severity grades relation biomarkers stress, thioredoxin reductase 1 (TrxR1)...
Aortic valve (AoV) stenosis is the third most common cardiovascular disease. The pathogenesis of AoV associated with an inflammatory process where MMPs serve important roles. aim present study was to determine association between matrix metalloproteinases (MMPs), tissue inhibitors (TIMPs) and factors, at various degrees severity compared control. A total 18 patients mild, 19 moderate 15 severe were included in stud, 50 individuals enrolled control group. determined by echocardiography....
Inflammation appears to be the cause of aortic valve (AoV) stenosis and identification predictive biomarkers is therefore imperative. The aim current study was evaluate potential role serum chemerin fibroblast growth factor-21 (FGF-21) in pathogenesis disease. A total 102 patients were selected based on certain criteria divided into an group a control group. Patients with AoV subdivided three groups depending severity according echocardiography criteria: Aortic jet velocity, Vmax (m/sec);...
Background and Objectives: Aortic valve stenosis (AS) develops with a pronounced local inflammatory response, where variety of growth factors are involved in the process, may have pro-inflammatory anti-inflammatory effect. The aim our study was to elucidate whether circulating factors: differentiation factor 15 (GDF-15), angiopoietin-2 (Ang-2), vascular endothelial A (VEGF-A), fibroblast 2 (FGF-2), 21 (FGF-21) could be proposed as clinically relevant biomarkers improve risk stratification AS...
Aortic valve stenosis (AS) develops not only with a pronounced local inflammatory response, but also oxidative stress is involved. The aim of this study was to evaluate the plasma levels thioredoxin-1 (TRX1), myeloperoxidase (MPO), chemerin, growth differentiation factor 15 (GDF-15), angiopoietin-2 (Ang-2), vascular endothelial A (VEGF-A), fibroblast 2 (FGF-2), 21 (FGF-21), and metalloproteinase (MMP)-1, -3, -9 in acquired AS patients as well clarify correlations TXR1 biomarkers regarding...
Analysis of Polymorphisms at the Adiponectin Gene Locus in Association with Type 2 Diabetes, Body Mass Index and Cardiovascular Traits Latvian Population Despite number recently conducted studies seeking to determine association between genetic variants adiponectin gene susceptibility type diabetes (T2D) increased body mass index (BMI), results obtained are often inconsistent. To impact common polymorphisms promoter coding regions on these conditions population, we selected ten SNPs...
Abstract The aim of the present study was to evaluate plasma levels chemerin, myeloperoxidase (MPO), fibroblast growth factor-21 (FGF-21), thioredoxin reductase-1 (TrxR1), and matrix metallopeptidase-9 (MMP-9) in acquired aortic valve (AoV) stenosis patients determine correlations between studied cellular factors, also clarify predictive values these factors as biomarkers AoV stenosis. were classified into three groups: 17 with mild stenosis; 19 moderate 15 severe Twenty-four subjects...
The aim of the study was to clarify correlations between body mass index (BMI), blood pressure (BP), and serum levels cytokines in female migraine patients. A total 14 migraineurs with aura, 12 without aura during their interictal period were compared 25 controls. Interleukin-8 (IL-8), soluble intercellular adhesion molecule-1 (sICAM-1), vascular cell (sVCAM-1), matrix metalloproteinase-9 (MMP-9), interferon gamma (IFN-γ), monocyte chemoattractant protein-1 (MCP-1), transforming growth...
Relation of Endothelial Dysfunction and Adipokines Levels to Insulin Resistance in Metabolic Syndrome Patients Obese metabolic syndrome (MS) patients were categorised into three groups: 44 with type 2 diabetes mellitus (T2DM)(D); 20 T2DM coronary artery disease (CAD) (DC), 26 MS alone (M). Eighteen healthy subjects selected as controls (C). resistance (IR) was assessed by HOMA-IR. Adiponectin, tumour necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), monocyte chemoattractant protein-1...
While our work passed through the peer-review process for publication in Stroke, Pilz et al published data demonstrating an inverse and independent correlation between adiponectin levels carotid intima-media thickness (IMT). 1 In this work, authors compared 140 obese juveniles (mean age 13.5Ϯ4.4years) with 100 age-matched, healthy, normal-weight controls demonstrated a significant negative serum IMT, even after controlling common cardiovascular risk factors.The do not report numbers of males...
Abstract Physical fitness, health, and physical endurance are important attributes of persons in military. The purpose the present study was to assess changes anthropometric parameters biochemical markers blood serum for participants a one-week combat training course (CTC) during which had high psychological loads combination with dietary limitation sleep deprivation. High cause level that indicative musculoskeletal system dysfunction. group included (n = 59) both genders aged 23 30 years....