A5061779231- Advanced Nanomaterials in Catalysis
- Cardiac electrophysiology and arrhythmias
- Lanthanide and Transition Metal Complexes
- Cardiac Fibrosis and Remodeling
- Luminescence Properties of Advanced Materials
- Skin Protection and Aging
- Mechanical Circulatory Support Devices
- Asthma and respiratory diseases
- Polyoxometalates: Synthesis and Applications
- Cardiac Structural Anomalies and Repair
- Ion channel regulation and function
- Allergic Rhinitis and Sensitization
- Sulfur Compounds in Biology
- Redox biology and oxidative stress
- Cardiovascular Function and Risk Factors
- MRI in cancer diagnosis
- Catalysis and Oxidation Reactions
- Cardiac Arrhythmias and Treatments
- Analytical Chemistry and Sensors
- Electrochemical sensors and biosensors
- Advanced MRI Techniques and Applications
- Neuroscience and Neural Engineering
- Cardiovascular Effects of Exercise
- Lipid Membrane Structure and Behavior
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
École Polytechnique
2014-2023
Institut de Chimie
2022
KU Leuven
2019-2020
Centre National de la Recherche Scientifique
2014-2017
Université Paris-Saclay
2017
Inserm
2014-2017
Interstitial fibrosis is an important component of diastolic, and systolic, dysfunction in heart failure (HF) depends on activation differentiation fibroblasts into myofibroblasts (MyoFb). Recent clinical evidence suggests that late-stage HF, not reversible. The study aims to examine the degree cardiac MyoFb end-stage HF potential for their phenotypic reversibility. Fibroblasts were isolated from left ventricle explanted hearts transplant recipients (ischemic dilated cardiomyopathy), nonused...
Collecting information on multiple pathophysiological parameters is essential for understanding complex pathologies, especially given the large interindividual variability. We report here multifunctional nanoparticles which are luminescent probes, oxidant sensors, and contrast agents in magnetic resonance imaging (MRI). Eu(3+) ions an yttrium vanadate matrix have been demonstrated to emit strong, nonblinking, stable luminescence. Time- space-resolved optical detection feasible after...
Abstract After myocardial infarction, resident fibroblasts (Fb) differentiate towards myofibroblasts (MyoFb), generating the scar tissue and interstitial fibrosis seen in adjacent myocardium. Fb MyoFb have potential to interact with cardiac myocytes (CMs) but insight into phenotype-specific role mode of interaction is still incomplete. Our objectives are further define modulation CMs by MyoFbs compared Fbs, as well direct contact through gap junctions vs. soluble mediators, using Fbs from...
Reactive oxygen species (ROS), and notably hydrogen peroxide H2O2, are cellular second messengers that known to control a variety of signaling processes. They can finely regulate the dynamics signal transduction, cell response ultimately tissue function. However, there very few local, quantitative time-resolved descriptions their organization at scale molecular reactions, due lack efficient sensors. We thus developed novel nanoprobe-based ROS detection system using simultaneous imaging...
Abstract The current trend for Magnetic Resonance Imaging points towards higher magnetic fields. Even though sensitivity and resolution are increased in stronger fields, T1 contrast is often reduced, this represents a challenge agent design. Field-dependent measurements of relaxivity thus important to characterize agents. At present, the field-dependent curves usually carried out field range 0 T 2 T, using fast cycling relaxometers. Here, we employ high-speed sample shuttling device switch...
Ventricular arrhythmias are a major complication after myocardial infarction (MI), associated with sympathetic activation. The structurally heterogeneous peri-infarct zone is known substrate, but the functional role of myocytes less well known. Recordings monophasic action potentials in vivo reveal that source delayed afterdepolarizations (DADs) and has high beat-to-beat variability repolarization (BVR) during adrenergic stimulation (isoproterenol, ISO). Myocytes isolated from region have...
Reactive oxygen species (ROS) are key regulators in numerous pathological contexts, including cancer or inflammation. Their role is complex, which justifies the need for methods enabling their quantitative and time-resolved monitoring vivo, perspective to profile tissues of individual patients. However, current ROS detection do not provide these features. Here, we propose a new method based on imaging lanthanide-ion nanoparticles (GdVO4:Eu), whose photoluminescence modulated by surrounding...