A5004895020- Immune cells in cancer
- Extracellular vesicles in disease
- SARS-CoV-2 and COVID-19 Research
- Inhalation and Respiratory Drug Delivery
- Sphingolipid Metabolism and Signaling
- SARS-CoV-2 detection and testing
- COVID-19 Clinical Research Studies
- Pancreatitis Pathology and Treatment
- Single-cell and spatial transcriptomics
- Asthma and respiratory diseases
- Neonatal Respiratory Health Research
- Influenza Virus Research Studies
- Endoplasmic Reticulum Stress and Disease
- Immunotherapy and Immune Responses
- Respiratory Support and Mechanisms
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- IL-33, ST2, and ILC Pathways
- Kruppel-like factors research
- Immune Cell Function and Interaction
- Pancreatic function and diabetes
- Platelet Disorders and Treatments
- Vaccine Coverage and Hesitancy
- Gastrointestinal motility and disorders
- Helicobacter pylori-related gastroenterology studies
- Amyloidosis: Diagnosis, Treatment, Outcomes
University of Liège
2016-2024
Abstract Resident tissue macrophages (RTM) can fulfill various tasks during development, homeostasis, inflammation and repair. In the lung, non-alveolar RTM, called interstitial (IM), importantly contribute to homeostasis but remain little characterized. Here we show, using single-cell RNA-sequencing (scRNA-seq), two phenotypically distinct subpopulations of long-lived monocyte-derived IM, i.e. CD206 + − as well a discrete population extravasating CD64 CD16.2 monocytes. IM are peribronchial...
Abstract Resident tissue macrophages (RTMs) are differentiated immune cells that populate distinct niches and exert important tissue-supportive functions. RTM maintenance is thought to rely either on differentiation from monocytes or self-renewal. Here, we used a mouse model of inducible lung interstitial macrophage (IM) niche depletion refilling investigate the development IMs in vivo. Using time-course single-cell RNA-sequencing analyses, bone marrow chimeras gene targeting, found...
Lung macrophages constitute a sophisticated surveillance and defense system that contributes to tissue homeostasis, host defense, allows the cope with myriad of insults antigens which lung mucosa is exposed. As opposed alveolar macrophages, interstitial express high levels type 2 major histocompatibility complex (MHC-II), hallmark antigen-presenting cells. Here, we showed IMs, like dendritic cells (DCs), possess machinery present soluble in an MHC-II-restricted way. Using ex vivo ovalbumin...
Abstract Background Nursing home (NH) residents have been severely affected during the COVID-19 pandemic because of their age and underlying comorbidities. Infection outbreaks in NHs are most likely triggered by infected workers. Screening for asymptomatic NH workers can prevent risky contact viral transmission to residents. This study examined effect BNT162b2 mRNA COVID‑19 (Comirnaty ® ; BioNTech Pfizer) vaccination on saliva excretion SARS-CoV-2 among workers, through weekly RT-qPCR...
Nursing home (NH) residents and staff have been severely affected by the COVID-19 pandemic. The aim of this study was to examine use weekly saliva RT-qPCR testing for SARS-CoV-2 detection among NH workers as a strategy control disease transmission within NHs in Belgium. From 16 November 27 December 2020, voluntary anonymous screening implemented cohort 50,000 across 572 Walloon region Belgium detect asymptomatic cases via using Diagenode sample collection device. Positive were isolated avoid...