Abstract Purpose: The major value of prognostic markers in potentially curable non-small cell lung cancer (NSCLC) should be to guide therapy after surgical resection. In this regard, the patients' immune status at time resection may important and also measurable. system has paradoxical roles during development. However, significance tumor-infiltrating lymphocytes is controversial. aim study elucidate epithelial stromal lymphocyte infiltration NSCLC. Experimental Design: Tissue microarrays...

Dipterological surveys were conducted in different sites western and central parts of northern Iran (Guilan, Mazandaran, Kordestan, East West Azerbaijan Ardabil provinces) during 2010–2011 using Malaise traps, 2012–2014 employing sweep nets. A total 110 species collected, including 42 Dolichopodinae. Eleven dolichopodine proved new to science, eight which are described here: Dolichopus fuscicercus sp. nov., D. subimmaculatus Gymnopternus flavitibia G. atratus Hercostomus setitibia H....

Automated soil moisture systems are commonly used in precision agriculture. Using low-cost sensors, the spatial extension can be maximized, but accuracy might reduced. In this paper, we address trade-off between cost and comparing commercial sensors. The analysis is based on capacitive sensor SKU:SEN0193 tested under lab field conditions. addition to individual calibration, two simplified calibration techniques proposed: universal all 63 a single-point using response dry soil. During second...

Abstract PROBEX (PROBabilities from EXemplars), a model of probabilistic inference and probability judgment based on generic knowledge is presented. Its properties are that: (a) it provides an exemplar satisfying bounded rationality; (b) “lazy” algorithm that presumes no pre‐computed abstractions; (c) implements hybrid‐representation, similarity‐graded . We investigate the ecological rationality find compares favorably with Take‐The‐Best multiple regression (Gigerenzer, Todd, & ABC...

Vimentin, nuclear factor-kappaB (NF-kappaB) p105, fascin, E-cadherin, TGF-beta, Par6 and atypical PKC are molecular markers that play an important role in cell differentiation. Herein, we investigate their prognostic impact primary non-small-cell carcinoma (NSCLC). Tumour tissue samples from 335 resected patients with stage I-IIIA were used. Tissue microarrays constructed duplicate cores of both neoplastic cells stromal immunohistochemically evaluated. In univariate analyses, high tumour...

The vascular endothelial growth factors (VEGF-A, -C, -D) and the VEGF receptors (VEGFR-1, -2, -3) are important molecular markers in angiogenesis lymphangiogenesis. This study elucidates prognostic significance of these tumor cells as well stroma resected non-small cell lung cancer tumors.Tumor tissue samples from 335 patients with stage I to IIIA disease were obtained microarrays constructed duplicate cores surrounding stromal each specimen. Immunohistochemistry was used evaluate expression...

An immunosorbent method using antiglutaredoxin‐Sepharose was developed for purification of glutaredoxin in high yield from a mutant strain Escherichia coli K 12 lacking thioredoxin reductase (C 10–17). The primary structure the protein determined by analyses [ 14 C]carboxymethylated and its proteolytic fragments obtained digestions with trypsin, clostripain, chymotrypsin staphylococcal Glu‐specific extracellular protease. single active‐center disulfide has , half‐cystine residues located at...

Aims: The major value of prognostic markers in potentially curable non‐small cell lung carcinoma (NSCLC) should be to guide therapy after surgical resection. significance tumour‐infiltrating macrophages, their growth factor, macrophage colony‐stimulating factor (M‐CSF), and its receptor, factor‐1 receptor (CSF‐1R), as well natural killer cells dendritic cells, is controversial. aim this study was elucidate the these epithelial stromal compartments NSCLC. Methods results: Tissue microarrays...

Hydrological climate change impact assessment is generally performed by following a sequence of steps from global and regional modelling, through data tailoring (bias-adjustment downscaling) hydrological to analysis assessment. This “climate-hydrology-assessment chain” has been developed with primary focus on applicability medium-sized rural basin, which still the main type domain investigated in this context. However, an increasing degree being at scales smaller or larger than basin....

Abstract Nitrate pollution in groundwater is a serious problem many parts of the world. However, due to diffuse and common spatially over-lapping character potential several non-point sources, it often difficult distinguish main nitrate sources responsible for pollution. For this purpose, we present novel methodology applied an intensely polluted area. Groundwater samples were collected monthly from April 2017 March 2018 Shimabara City, Nagasaki, Japan. Soil seasonally at soil surface 50 cm...

Abstract. Estimating the change in groundwater recharge from an introduced artificial system is important order to evaluate future water availability. This paper presents inverse modeling approach quantify contribution both ephemeral river channel and based on floodwater spreading arid Iran. The study used MODFLOW-2000 estimate for steady- unsteady-state conditions. model was calibrated verified observed hydraulic head observation wells precision, uncertainty, sensitivity were analyzed all...

Water harvesting and artificial recharge have been a traditional solution to water scarcity problems in the arid semi-arid Middle East for thousands of years. These techniques are increasingly being encouraged, recently there has renewed interest find improved methods many countries. In this study, balance calculations groundwater modelling were utilized investigate performance hydrological function an technique, referred as floodwater spreading system, Iran. The amount system studied varied...

The present article is an assessment of wastewater treatment processes in the oil refinery sector Kazakhstan by comparing relevant experience developed and developing countries. legislation this sphere, methods, discharge process effect on environment were evaluated following international national regulations. In our study, systems three factories assessed. Results show that, even though environmental regulation promotes polluter pays principle follows World Health Organization (WHO)...

In this study, field experiments and numerical simulations for different drip irrigation treatments in a sandy loam soil were conducted to investigate water salinity distribution as well dye infiltration patterns. Three treatments, surface without with plastic mulch (T 1 T 2 , respectively) subsurface 3 ), used. Daily bi‐weekly regimes used each treatment. After completion of treatment, horizontal sections dug 10 cm intervals. Dye patterns photographed using digital camera pore electric...

Petrochemical enterprises in Kazakhstan discharge polluted wastewater into special recipients. Contaminants infiltrate through the soil groundwater, which potentially affects public health and environment safety. This paper presents evaluation of a 7-year monitoring program from one factories includes nineteen variables nine wells during 2013-2019. Several multivariate statistical techniques were used to analyse data: Pearson's correlation matrix, principal component analysis cluster...

Agricultural-driven land-use changes have extensively reshaped landscapes, leading to increased soil erosion and water demand. Achieving long-term agricultural sustainability requires a balanced interaction among resources, land cover, climate. However, how this interconnected system will respond climate change remains uncertain. This study aims assess (i) the current impacts of cover on balance variables (ii) projected future conditions.  Field observations were conducted 100...

In this study we applied a large-scale hydrological model, with an irrigation routine based on the FAO guidelines for computing crop water requirements. The aim was to quantify changes in irrigation-water demand under three different climate scenarios until end of century nine types crops almost 40,000 sub-basins covering Sweden (450 000 km2) located Scandinavian Peninsula northern Europe. Our results showed that, average, is projected increase by century. However, found that driest years...

Abstract A nonlinear prediction method, developed based on the ideas gained from deterministic chaos theory, is employed: (a) to predict monthly runoff; and (b) detect possible presence of in runoff dynamics. The method first reconstructs single-dimensional (or variable) series a multi-dimensional phase space represent its dynamics, then uses local polynomial approach make predictions. Monthly observed at Coaracy Nunes/Araguari River basin northern Brazil studied. predictions are found be...