A5004755900- Process Optimization and Integration
- Innovative Microfluidic and Catalytic Techniques Innovation
- Advanced Control Systems Optimization
- Advanced Optimization Algorithms Research
- Crystallization and Solubility Studies
- Sparse and Compressive Sensing Techniques
- Numerical Methods and Algorithms
- Numerical methods for differential equations
- Simulation Techniques and Applications
- Complexity and Algorithms in Graphs
- Modeling and Simulation Systems
Cargill (United States)
2018
University of Edinburgh
2016
Massachusetts Institute of Technology
2011-2014
The capital, operating, and overall costs of a dedicated continuous manufacturing process to synthesize an active pharmaceutical ingredient (API) formulate it into tablets are estimated for production scale 2000 t per year, with raw material cost, yield, API loading varied over broad ranges. Costs compared batch in facility. Synthesis begins key organic intermediate three synthetic steps before the final API; results given (KI) $100 $3000/kg, drug loadings tablet 10 50 wt %. novel described...
Time-varying, or dynamic, experiments can produce richer data sets than sequences of steady-state using less material and time. A case study demonstrating this concept for microreactor is presented. Beginning with five kinetic model candidates the reaction phenylisocyanate t-butanol, an initial dynamic experiment showed that two models gave a similar quality fit to experimental data, whereas remaining three significantly poorer fits. Next optimal was designed discriminate between models....