It has been shown in several organisms that multiple cis-regulatory modules (CRMs) of a gene locus can be active concurrently to support similar spatiotemporal expression. To understand the functional importance such seemingly redundant CRMs, we examined two CRMs from Drosophila snail locus, which are both ventral region pre-gastrulation embryos. By performing deletion series ∼25 kb DNA rescue construct using BAC recombineering and site-directed transgenesis, demonstrate not redundant. The...

Post-translational histone modifications abound and regulate multiple nuclear processes. Most are targeted to the amino-terminal domains of histones. Here we report identification characterization acetylation lysine 56 within core domain H3. In crystal structure nucleosome, contacts DNA. Phenotypic analysis suggests that is critical for function it modulates formamide resistance, ultraviolet radiation sensitivity, sensitivity hydroxyurea. We show acetylated form H3 (H3-K56) present during...

The NK homeodomain factor Tinman is a crucial regulator of early mesoderm patterning and, together with the GATA Pannier and Dorsocross T-box factors, serves as one key cardiogenic factors during specification differentiation heart cells. Although basic framework regulatory interactions driving development has been worked out, only about dozen genes involved in have designated direct target to date, detailed information functional architectures their cardiac enhancers lacking. We used...

Cis -regulatory modules (CRMs) function by binding sequence specific transcription factors, but the relationship between in vivo physical and regulatory capacity of factor-bound DNA elements remains uncertain. We investigate this for well-studied Twist factor Drosophila melanogaster embryos analyzing genome-wide occupancy testing functional significance occupied regions motifs within regions. ChIP-seq data efficiently identified previously studied Twist-dependent CRMs robustly predicted new...

A canonical problem for swarms of agents is to collectively choose one multiple options in their environment. We present a novel control strategy solving this problem—the first be free arithmetic computation. The do not communicate with each other nor they store run-time information. They have line-of-sight sensor that extracts ternary digit information from the At every time step, directly map onto constant-value motor commands. evaluate both simulated and physical e-puck robots. By...

Recognising previously visited locations is an important, but unsolved, task in autonomous navigation. Current visual place recognition (VPR) benchmarks typically challenge models to recover the position of a query image (or images) from sequential datasets that include both spatial and temporal components. Recently, Echo State Network (ESN) varieties have proven particularly powerful at solving machine learning tasks require spatio-temporal modelling. These networks are simple, yet neural...

We study the problem of controlling a swarm anonymous, mobile robots to cooperatively cover an unknown two-dimensional space. The novelty our proposed solution is that it applicable extremely simple lack run-time computation or storage. requires only single bit information per robot-whether not another robot present in its line sight. Computer simulations show deterministic controller, which was obtained through off-line optimization, achieves around 71-76% coverage test scenario with no...

Abstract Fibroblast growth factors (FGFs) are important regulators of retinal development and survival. We examined the expression distribution FGF9 its preferred receptors FGFR2IIIc FGFR3IIIc in this tissue. transcripts whole rat retina were detected by RT‐PCR but not present purified cultured Müller glia. Transcripts appeared as 3.2‐kb 4.0‐kb bands on Northern blots, Western blotting revealed FGF9‐immunoreactive at 30 55 kDa. mRNA demonstrated a biphasic profile, elevated birth adulthood,...

This paper summarizes our group’s efforts in the offensive language identification shared task, which is organized as part of International Workshop on Semantic Evaluation (Sem-Eval2020). Our final submission system an ensemble three different models, (1) CNN-LSTM, (2) BiLSTM-Attention and (3) BERT. Word embeddings, were pre-trained tweets, are used while training first two models. BERTurk, BERT model for Turkish, also explored. submitted approach ranked second best Turkish sub-task.

There was an error published in Development138, 4075-4084.The authors inadvertently re-displayed the image from Fig. 1D 1B. The corrected 1 is shown below. This change does not affect or alter results conclusions of study.The apologise to readers for this mistake.In addition, wish clarify that images 6A, 6B and 6C are unmanipulated versions those 5D, 5B 5A, respectively.

Modular reconfigurable robots are touted for their flexibility, as bodies can assume a wide range of shapes. A particular challenge is to make them move efficiently in 3D without compromising the scalability system. This paper proposes decentralized and fully reactive controllers pose control modular robots. The operate liquid environments, by routing fluid through themselves. Each module uses only two bits sensory information per face. Additionally, modules use up five that exchanged via...

Modular robotic systems comprise groups of physically connected modules which can be reconfigured to create morphologies that suit an environment or task.One method reconfiguration is via subtraction, where extraneous disconnect from initial configuration, before being removed by external intervention.In this paper, we consider approach in two dimensions, here termed active unwanted traverse a configuration order remove themselves safely, without the need for intervention, making it form...

We propose stochastic control policies for gathering a group of embodied agents in two-dimensional square tile environment. The are fully decentralized and can be executed on anonymous, oblivious with chirality, but no sense orientation. require only 4 ternary digits information. prove that agents, irrespective initial positions, will almost surely reach Pareto optimal configuration finite time. For one the policies, computer simulations show groups up to 20 consistently configurations,...