A5018398797- Synthesis and Characterization of Heterocyclic Compounds
- Synthesis and biological activity
- Synthesis and Reactions of Organic Compounds
- Click Chemistry and Applications
- Crystallization and Solubility Studies
- Synthesis and Biological Evaluation
- X-ray Diffraction in Crystallography
- Chemical Synthesis and Analysis
- Synthesis and Reactivity of Heterocycles
- Quinazolinone synthesis and applications
- Biotin and Related Studies
- Cancer Mechanisms and Therapy
- Computational Drug Discovery Methods
- Synthesis and Catalytic Reactions
- Chemical Reaction Mechanisms
- Phenothiazines and Benzothiazines Synthesis and Activities
Institute of Fine Organic Chemistry of Scientific - Technological Center of Organic and Pharmaceutical Chemistry
2022-2025
The synthesis of pyrimido[2,1-f][1,2,4]triazines was performed in four steps. Compounds obtained by acylation the starting amino esters thieno[2,3-b]pyridines were reacted with various amines. resulting derivatives underwent cyclization presence hydrazine hydrate leading to new aminomethyl thieno[3,2-d]pyrimidines. Further latter resulted unique heterocyclic systems: pyrido[3'',2'':4',5']thieno[3',2':4,5]pyrimido[2,1-f][1,2,4]triazines. uniqueness these systems lies fact that even...
Background/Objectives: Approximately 1% of people worldwide suffer from epilepsy. The development safer and more effective antiepileptic medications (AEDs) is still urgently needed because all AEDs have some unwanted side effects roughly 30% epileptic patients cannot stop having seizures when taking current AEDs. It should be noted that the derivatives pyrazolo[3,4-b]pyridine are important core structures in many drug substances. aim this study to synthesize new piperazino-substituted...
The synthesis of new original bicyclic pyridine-based hybrids linked to the 1,2,3-triazole unit was described via a click reaction. anticonvulsant activity and some psychotropic properties compounds were evaluated. biological assays demonstrated that studied showed high properties. five most active (7a, d, g, j, m) contain pyrano [3,4-c]pyridine cycle with methyl group in pyridine ring their structures. Furthermore, molecular docking studies performed, results are agreement experimental data.
Herein, we describe the synthesis of new hybrids linked to 1,2,3- and 1,2,4-triazole units. Hybrids connected a 1,2,3-triazole ring were synthesized using well-known click reaction. The 1,2,4-triazole-based was carried out 2-[(4-cyano-1-methyl(2-furyl)-5,6,7,8-tetrahydroisoquinolin-3-yl)oxy]acetohydrazides as starting compounds. compounds evaluated for their anticonvulsive activity
In this paper we describe an efficient method for the synthesis of new heterocyclic systems: furo[2,3-c]-2,7-naphthyridines 6, as well a preparation 1,3-diamino-2,7-naphthyridines 11. For first time, Smiles rearrangement was carried out in 2,7-naphthyridine series, thus gaining opportunity to synthesize 1-amino-3-oxo-2,7-naphthyridines 4, which are starting compounds obtaining furo[2,3-c]-2,7-naphthyridines. The cyclization alkoxyacetamides 9 proceeds via two different processes: expected...
Continuing our studies in the field of new heterocyclic compounds with biological interest, herein we report synthesis and anticancer activity N- S-substituted derivatives tetracyclic pyrido[3',2' : 4,5]thieno[3,2-d]pyrimidines. In this regard, starting from thieno[2,3-b]pyridine-2-carboxylates, corresponding 8(9)-aminopyrido[3',2' 4,5]thieno[3,2-d]pyrimidin-7(8)-ones, as well chloro were obtained. Based on latter, amino, hydrazino S-alkyl 4,5]thieno[3,2-d]pyrimidines synthesized...
Herein we describe the synthesis and rearrangement of 1,3-diamino-2,7-naphthyridines 1-amino-3-oxo-2,7-naphthyridines. In case 1,3-diamino-2,7-naphthyridines, it was found that reaction influenced by both substituent at 7th position 2,7-naphthyridine ring nature cyclic amine 1st position. The influence mainly steric. 1-amino-3-oxo-2,7-naphthyridines with amines studied for first time. It revealed these substrates, occurs faster without any alkyl groups. We also observed nucleophilic addition...
An efficient synthesis of new pentaheterocyclic systems based on the triazolo[3,4-a]-2,7-naphthyridine core is described.Thus, by cyclocondensation thieno [2,3-c][1,2,4]triazolo[3,4-a]-2,7-naphthyridine with formamide, corresponding thieno[3,2-d]pyrimidine was obtained, starting from which N-alkyl, 11chloro and 11-amino(hydrazino) derivatives were synthesized.Furthermore, reaction pyrazolo [3,4c][1,2,4]triazolo(tetrazolo)-2,7-naphthyridines, formed via a condensation/cyclization process,...