This paper reports the synthesis of a new heterocyclic compound, 2,7-dicloropyrido[2,3-g]quinoline-3,8-dicarbaldehyde, from p-phenylene diamine by converting p-acetanilide (1) and reacting with Vilsmeier-Haack reagent (2). Chalcone(3) is produced when two moles 2-acetyl naphthalene respond carbaldehydes in compound chalcone serves as for quantifying amino group-containing pharmaceutical compounds. At same time, sensitive spectrophotometric technique has been created used preparations to...

An accurate, simple, and sensitive indirect spectrophotometric method which proposed developed for the determination of paracetamol in different pharmaceutical preparations. The was based on acid hydrolysis PAR to produced p-aminophenol (PAP), PAP diazotization with nitrite ion form corresponding diazonium salt, followed by coupling histidine reagent alkaline medium azo dye that showed maximum absorbance at 430 nm. Beer's law obeyed concentration rage 10-500 µg/20 ml (i.e. 0.5-25 ppm). molar...

Background: The eco-friendly power of hydrogen peroxide oxidant produced water that was the only by-product after oxidation.Unfortunately, its oxidation towards chalcones and analogs substantially low, therefore, it normally used together with a catalyst or converted to hydroperoxides in order improve power.Objective: This research aimed study epoxidation chemistry.Hence, as potential for different techniques catalysts.Methodology: Advantageous effects (reline) (derived from two moles...

Abstract Focus of this study is on the use hydrazone compound (3) (N-(4-bromobenzylidene)-4-(1H-indol-3-yl) butane hydrazide), which was previously prepared from reaction p-bromobenzaldehyde with corresponding hydrazide (2) , as an intermediate for synthesis azetidine, thiazolidine, tetrazole, oxadiazole and phthalazine heterocyclic compounds through its some cyclic reagents catalysts such chloro acetyl chloride, thioglycolic acid, sodium-azid, lead dioxide Hydrogen chloride gas. The were...

In this work, seven new Schiff bases were obtained in two ways. method (A), an equimolecular aqueous solution of glucose and alcoholic amine refluxed for three hours, (B), a deep eutectic solvent (Reline), prepared from one mole choline chloride moles urea,was used as catalyst. The reaction yield percentage the traditional (A) was found to be 60-79%, catalytic (Method B) using (Reline) 88-95%. system is environmentally friendly with triple benefit increased yield, elimination solvent, faster...

Two new ligands, methyl 4-amino antipyrinyl dithiocarbamates (MAC) and benzyl (BAC), were synthesized from antipyrine corresponding or halides with potassium hydroxide in dimethylformamide. Then they coordinated five divalent transition metals: M = Mn, Co, Ni, Zn, Cu(II) to produce ten novel complexes, [M(MAC)2]Cl2 I(a-e) [M(BAC)2]Cl2 II(a-e), which characterized by some physical properties spectral methods, elemental analyses, molar conductance, magnetic susceptibility, addition 1H NMR,...

A series of heterocyclic compounds containing oxygen and nitrogen atoms, isoxazoline ІI(a-d) another two pyrazolinesІII(a-d) phenylpyrazolines IV(a-d) were prepared by the reaction a proper azachalcones І(a-d) with hydroxylaminehydrochloride, hydrazine hydrate or phenylhydrazine. These characterized 1H-NMR , CHN IR UV spectra in addition to their some physical properties. Also, these screened for biological activities theoretical calculation which shows that product IVa obtained from 1,2 –...

New complexes with a mixture of aspirin (acetylsalicylic acid ) methyldopa or paracetamol were synthesized via the reflux reaction using basic medium to deprotonate ligands.These new Mn(II),Fe(II),Co(II),Ni(II) and Cu(II) acid), have characterized FTIR, UV-visible spectra, magnetic susceptibility, flame atomic absorption, C.H.N.S analysis melting points measurements.The two mixed ligands been found act as bidentate chelating agents.Aspirin acid) coordinate metal ions through oxygen Aspirin's...

The new heterocyclic compounds 1,5-Dimethyl-2-phenyl-4-(5-aryl-4,5-dihydro-1H-pyrazol-3-ylamino)-1,2-dihydropyrazol-3-ones (iiia-b) and 1,5-dimethyl-2-phenyl-4-(5-aryl-4,5-dihydroisoxazol-3-ylamino)-1,2-dihydropyrazol-3-ones (iva-b) were synthesized in the first route this work by refluxing ethanolic solution of hydrazine hydrate with N-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)cinnamamid (iia) or...

Synthesis of mixed metal complexes were done through reaction two drugs such as antipyrine, or ciprofloxacin with Metronidazole to have eight complexes. Physical, chemical and antibacterial activity new studied. These ligands further coordinating bivalent transition metals in a metal: mixture ratio 1:1. characterized by using elemental analysis physical properties, addition molar conductance DMF which showed non-electrolytic behavior. FT-IR spectra revealed absorption bands for that agreed...

Glycolic acid, is known as hydroxyl-acetate a vital chemical compound that have many applications, so, its recovery process of glycolic acid mandatory and essential from source production, processes are used to remove aqueous solution.In this article, adsorption applied via using grape leaf residues (GLR) adsorbent.Thermodynamic kinetic studies were prove the optimal conditions process.

Condensation of 2-aminoethane sulfonic acid(Taurine) and benzaldehyde in sodium hydroxide ethanolic solution gave the Schiff base [2-(benzylidene amino) ethanesulfonic acid(L)] . This particularly bind to metal ions Co (II) ,Ni (II),Cu , Zn (II)and Hg 2:1 molar ratio via N atom lone pair oxygen acid (the most active positions) as a neutral bidentate ligand form complexes general formula [ML2. 2H2O]Cl2. Characterization these were octahedral geometry information obtained from IR UV spectra...

Chroman-4-one derivatives 1(a-i) were prepared by Pechman condensation of phenol or its substitutions with cinnamic acid using polyphosphoric acid. These reacted hydrazine hydrate in refluxing ethanol to yield pyrazoline (2). The utility the Claisen-Schmidt synthesis -3-arylidene- substituted 2-phenyl chroman-4-one 3(a-e) reaction proper 4-chromanone (1) aromatic aldehydes presence KOH. Pyrazolines 4(a-c) synthesized arylidenes 2 pyridine. Finally, arylidines urea gave pyrimidin-2-ones...

The ab- initio / HF of(6-31) ( the basic sets parameters that make molecule more stable) according to (Gaussian) program and density functional theory of polarization) PM3 semiempericalmethod,showed net charge distributions for 4-aminobenzene sulfonamide (sulfanilamide)(SAM2) Sulfa pyridine( SP) (the active drugs) were less than those prodrugsProntisil (PROTO1) Salfalazine (SASP4) which indicated stabilities easy formation (or liberation) these drugs. In addition that, liberated drugs also...

(E)-3-Chloro-4-arylidene-2,3-dimethyl-1-phenylpyrazolidin-5-one 1(a-c) which were used as synthon for synthesis of all target compounds prepared from the reaction 3-chloro-2,3-dimethyl-1-phenylpyrazolidin-5-one(Chlorophenazone)with aromatic aldehydes by 1,4-Michael addition . 4-Aryl-3-chloro-2,3-dimethyl-1-phenyl-2,3-dihydro-1H-pyrazolo[3,4-d]pyrimidine-6(5H)- one2(a-c) and -6(5H)-thiones 2(d-f)were in low yields(40-50%) 1 (a-c) with urea or thiourea respectively refluxing ethanol. The...

The key intermediates in the present study to synthesize title bridge-head nitrogen heterocycle compounds were N-substituted semicarbazides 2(a-c), which prepared by hydrazinolysis of ethyl substituted carbamates 1(a-c) with hydrazine hydrate. These reaction proper amines and ethylchloroformate. these ethanolic solution carbon disulfide under strong basic conditions at room temperature, followed acidification resulted formation corresponding potassium (2-arylcarbamoyl)hydrazine...