Microbial production of monoterpenes provides a promising substitute for traditional chemical-based methods, but their is lagging compared with sesquiterpenes. Geraniol, valuable monoterpene alcohol, widely used in cosmetic, perfume, pharmaceutical and it also potential gasoline alternative. Previously, we constructed geraniol strain by engineering the mevalonate pathway together expression high-activity synthase. In this study, further improved through reducing endogenous metabolism...

Abstract Tributyltin (TBT), a proven endocrine‐disrupting chemical, is well known to induce imposex in female gastropods. Herein we demonstrate the effects of low doses tributyltin chloride (TBTCl) on offspring KM mice. Pregnant mice were administered by gavage with 0, 1, 10, or 100 μg TBTCl/kg body weight/day from day 6 pregnancy through period lactation. TBTCl dramatically advanced age onset vaginal opening (VO) and first estrus, reduced weights at VO estrus. Furthermore, perinatal...

We present a pumping scheme for quasi-three-level solid-state laser. The uses slab laser configuration with the pump light incident from corners. A diode-corner-pumped composite Yb:YAG-YAG operating in high-power cw mode was designed to prove scheme. As much as 520 W of output power obtained single 1-mm-thick 0.5-at. %-doped Yb:YAG. slope efficiency and optical-to-optical respect were 32% 25%, respectively. This result shows validity corner-pumping concept its feasibility development lasers.

Auditory neural stimulation with pulsed infrared radiation has been proposed as an alternative method to activate the auditory nerves in vivo. Infrared wavelengths from 1800–2150 nm high water absorption were mainly selected previous studies. However, few researchers have used short-wavelength (SWIR) for nerve and limited pulse parameters variability investigated so far. In this paper, we pioneered use 980 SWIR laser adjustable parameter a stimulus act on deafened guinea pigs’ cochlea Pulsed...

We have developed a slab laser design based on conduction cooling and novel pumping geometry called corner pumping. The uses crystal configuration with the pump light incident from corners. A maximum output power of over 1kW was achieved 1mm thick Yb:YAG/YAG (YAG=yttrium aluminum garnet) structure 0.5at.%-doped Yb:YAG. slope efficiency optical-to-optical respect to total were 42.8% 33.6%, respectively. At this electrical-to-optical conversion system 16.8%.

A high efficiency, continuous-wave, narrow linewidth, pump-enhanced optical parametric oscillator (OPO) at 3.8 µm was demonstrated, which pumped by a 1064 nm fiber laser with linewidth of 18 kHz. The low frequency modulation locking technique employed to stabilize the output power. wavelengths signal and idler were 1475.5 3819.9 25 °C, respectively. structure applied, leading maximum quantum efficiency over 60% pump power 3 W. light is 1.8 W 363 excellent tuning performance OPO also...

The tumor microenvironment (TME) of breast cancer (BC) is depicted as an immunosuppressive dwelling that comprises a myriad cell types embedded in the extracellular matrix. As one most abundant populations within TME, cancer-associated fibroblasts (CAFs) play indispensable roles increasing aggressiveness and promoting resistance to standard-of-care therapies. Extracellular vesicles (EVs) represent diverse array biological nanoparticles, encompassing exosomes, microvesicles, apoptotic bodies....

Introduction Mesenchymal stem cells can develop into osteoblasts, making them a promising cell-based osteoporosis treatment. Despite their therapeutic potential, molecular processes are little known. Bioinformatics and experimental analysis were used to determine the of bone marrow mesenchymal cell (BMSC) therapy for postmenopausal (PMO). Material methods We weighted gene co-expression network (WGCNA) isolate core sets from two GEO microarray datasets (GSE7158 GSE56815). GeneCards found...

A high efficiency Yb:YAG/YAG composite slab laser is presented, in which the corner-pumped scheme adopted. The a crystal of Yb:YAG bonded thermally with undoped YAG at both edges. pump light from diode arrays coupled into through four chamfers corners independently. absorption studied, and an analysis method has been developed as guide to optimize geometric parameters slab, obtain higher uniformity. influence internal thermal lens on resonator analyzed. 1016 W continuous-wave output obtained...

Noise from optical and electronic components of a fiber optic gas sensor system using wavelength modulation the DFB laser diode in either transmission or reflection mode were investigated. Our experimental results indicate that reflective type cells give poorer performance due to interference effects connectors joints within compare transmissive cell. Intensity noise coupler, collimator, was measured its affection sensing discussed. In order raise signal ratio (SNR), processing methods, such...

A model reference adaptive modeling method of ball screw feed system is proposed. Using a low-level with excellent dynamic characteristics as the and controlled object, this paper establishes by Narendra program, achieving exact match between adjustable through experiment deriving system. Then taking X axis X-Y work table an example, second-order established method. When 40000 pulse signals are input into in 160s respectively, output error two within ± 0.005mm, thus testifying higher...

The increasing penetration of renewable energy sources (RESs) brings about critical challenges on power system frequency stability. More specially, the RESs are integrated into systems through electronic converters, and provide less inertia to counter deviations after contingencies. This paper proposes an event-driven fast response (EFFR) approach based fuzzy logic controller (FLC), in order improve control under serious An framework is established, which contingencies corresponding...

Laser can stimulate sound wave, its possible for fiber laser to evoke neural activity safely and produce the auditory perception, this acts as electrode role in cochlear implant. Moreover, is characterized by definite direction optical signal between adjacent fibers dont readily interfere. Therefore, implant based on optoacoustic effect promising. The design preparation of an experimental system introduced paper. selection source control methods were discussed, testing results effect,...

To optimize the supplier selection and order allocation procedures of purchasing management improve their efficiency, this study employs mathematical statistics theory optimization algorithm in building a two-stage analysis method implemented MATLAB LINGO software. Specifically, AHP-EM TOPSIS methods are used to select suppliers phase 1. The weights produced stage 1 applied multi-objective mixed-integer programming model 2. On basis an example, impact information sharing rate on selection,...

This paper presents the uniform concentration inequality for stochastic integral of marked point processes. We developed a new chaining method to obtain results. Our main result is presented under an entropy condition partitioning index set integrands. improvement work van de Geer on exponential inequalities martingales in 1995. As applications result, we also obtained functional indexed empirical processes and Kakutani–Hellinger distance maximum likelihood estimator.

In this paper, we develop a quasi-cw InGaAs microlens-free diode arrays side-pumped Yb:YAG slab laser which operates at 25Hz. The pump light is transmitted by lensduct transmission efficiency measured about 80%. cavity plane-concave. We have achieved l6mJ output energy using 8mm X 3mm 1mm dimension and 5at.% Yb doped crystal with 345mJ input of operate in ims pulse mode. For another 2mm(5at.%) crystal, 8.7mJ obtained; the beam quality factor M2 values are to be 5.83 7.66 vertical horizontal...

The propagation of the pump radiation in active slab elements is considered. Conditions total internal reflection are obtained, and used to construct a series graphical illustrations characteristics different elements.

Background: The contribution of natural antisense transcripts (NATs) to tumorigenesis is an area intensive investigation. Previously, we demonstrated highly expressed SPINT1-AS1 in colorectal cancer (CRC) was linked poor clinical outcome. In this study, investigated the regulatory role on CRC cell phenotypes and determined expression pattern exosomal SPINT1-AS1.Methods: Loss- gain-of-function assays were used evaluate regulation ability phenotypes. Strand-specific RT-qPCR detected a cohort...