A5027621335- CAR-T cell therapy research
- Integrated Circuits and Semiconductor Failure Analysis
- Monoclonal and Polyclonal Antibodies Research
- Personality Disorders and Psychopathology
- Obsessive-Compulsive Spectrum Disorders
- Neonatal and fetal brain pathology
- Virus-based gene therapy research
- Rheumatoid Arthritis Research and Therapies
- Electron Spin Resonance Studies
- Pharmaceutical Economics and Policy
- Biomedical Ethics and Regulation
- Metastasis and carcinoma case studies
- Photoreceptor and optogenetics research
- Gastrointestinal disorders and treatments
- Mesenchymal stem cell research
- Biosimilars and Bioanalytical Methods
- Blood disorders and treatments
- Pharmaceutical studies and practices
- Neutropenia and Cancer Infections
- Advancements in Semiconductor Devices and Circuit Design
- Gastrointestinal Tumor Research and Treatment
- Acute Myeloid Leukemia Research
- Immunodeficiency and Autoimmune Disorders
- Pneumonia and Respiratory Infections
- COVID-19 Clinical Research Studies
Vall d'Hebron Hospital Universitari
2015-2025
Centro de Investigación Biomédica en Red de Salud Mental
2015
The epidemiological and clinical characteristics of solid organ transplant (SOT) patients during the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) epidemic remains unclear. We conducted a matched retrospective cohort study to compare outcomes among SOT recipients with general population assess immunosuppression management.Adult laboratory polymerase chain reaction-confirmed SARS-CoV-2 infection admitted tertiary-care hospital in Barcelona, Spain, from March 11 April 25, 2020,...
ABSTRACT Background Acute kidney injury (AKI) occurs in 30% of patients infused with chimeric antigen receptor (CAR) T-cells. The purpose this study was to identify risk factors and long-term outcomes after AKI who received CAR T-cell therapy. Methods Medical records 115 adult R/R hematological malignancies treated CD19-targeted T-cells at Vall d'Hebron University Hospital between July 2018 May 2021. Baseline demographic data including age, gender, ethnicity, body mass index (BMI),...
Importance Acute adverse events (AEs) after chimeric antigen receptor (CAR) T-cell infusion are well documented, but less information is available regarding the long-term toxic effects. Objective To assess occurrence of late AEs for adult patients with large B-cell lymphoma (LBCL) treated commercially CD19-targeted CAR T cells. Design, Setting, and Participants A prospective, observational, clinical practice cohort study was conducted from September 1, 2018, to December 31, 2022, among 172...
The purpose of this paper was to describe whether there are some relationships between amikacin serum levels and central conduction time in brainstem auditory evoked potentials (BAEP) within therapeutic range newborns as index drug toxicity centers neonatally exposed infants. We performed a cross-sectional study compare BAEP from 35 infants under administration 24 control infants; both examinations were blinded investigators. Bivariate partial correlations calculated measurements treated...
Acute kidney injury (AKI) occurs in 30% of patients infused with chimeric antigen receptor (CAR) T-cells. The purpose this study was to identify risk factors and long-term outcomes after AKI who received CAR T-cell therapy.
Objectives To describe mesenchymal stromal cells (MSCs) in the treatment of hematopoietic stem cell transplantation (HSCT) complications and to assess its safety efficacy. Methods Single-center retrospective study (2016–2023). Patients under 20 years who received MSCs for HSCT-related were included. Results Thirty patients (53.7% boys), median age at transplant 11 (range 2–19) indications were: graft-vs.-host disease (GVHD) 18 (60%), them 13 had acute GVHD (43.3%) 5 chronic (16.7%); Grade...
<h3>Background</h3> Orphan drugs (ODs) are designed to treat rare diseases (RD), which those affecting a small number of people (prevalence <1/2000 inhabitants). <h3>Purpose</h3> To assess the economic impact used RD in hospital outpatient paediatric pharmacy (HOPP) and day (PDH). <h3>Material methods</h3> Observational, retrospective, transversal study conducted at third-level maternal child University Hospital during 2016. All patients(<18 years' old) were included, as well adults...
Substance-dependent patients(SDP) have more personality disorders(PD) than general population; and they present frequent severe levels of depression anxiety. To study cluster C disorders in SDP. We included a clinical sample 822(621 males) SDP according to the DSM-IV-TR criteria seeking treatment Outpatient Drug Clinic Vall d'Hebron Barcelona, Spain. The assessment process consisted three interview sessions conducted by trained psychiatrists psychologists using SCID I II, BDI, STAI-R/S....
<h3>Background</h3> Intravenous immunoglobulin (IVIG) is the standard of care for humoral immunodeficiencies (HID) and several systemic autoimmune diseases. Its chronic administration represents an important economic logistical impact. <h3>Purpose</h3> To assess real time infusion IVIG compared to established maximums analyse which factors could affect it, in order find out if rate be higher. <h3>Material methods</h3> An observational, ambispective study with patients chronically receiving...
<h3>Background and importance</h3> Tofacitinib baricitinib are oral Janus kinase inhibitors (JKi) approved for the treatment of rheumatoid arthritis (RA), offering an alternative in patients who have not responded or tolerated previous lines because adverse effects, complications other reasons. In pivotal clinical trials, had higher DAS28-ESR than our were less pretreated with biologic disease modifying antirheumatic drugs (bDMARDs). Lower effectiveness real world compared trials has been...
<h3>Background and importance</h3> Hypercholesterolaemia leads to a higher risk of atherosclerosis cardiovascular events. Familial hypercholesterolaemia is more resistant usual treatments. In 2015, the PCSK9 inhibitors (PCSK9I) alirocumab evolocumab were approved for primary (heterozygous family (HFHe) non-familial (HNF)) mixed dyslipidaemia (DM). Due their recent approval high cost, it crucial evaluate real world results. <h3>Aim objectives</h3> To analyse long term effectiveness PCSK9I...
<h3>Background and importance</h3> Aztreonam lysine inhalation solution (AZLI) is approved for nebulised treatment (nebT) of pulmonary <i>Pseudomonas aeruginosa</i> infections in patients with cystic fibrosis (CF). The clinical benefit AZLI non-CF, such as bronchiectasis (BC) or lung transplant (LT) chronic gram negative infection, has not been clearly established. <h3>Aim objectives</h3> To assess the safety effectiveness nebT non-CF BC LT colonised by bacteria. <h3>Material methods</h3>...
Introdução: O adenocarcinoma primário do intestino delgado é raro, representando menos de 5% todos as neoplasias malignas trato digestivo, surgindo 10 a 13% das vezes no íleo. São tumores difícil diagnóstico e, frequentemente, manifestam-se como abdômen agudo obstrutivo. A intussuscepção íleo-cólica ocasionada por íleo terminal uma possibilidade raramente descrita.