A5102743393- Hearing, Cochlea, Tinnitus, Genetics
- Hearing Loss and Rehabilitation
- Lung Cancer Diagnosis and Treatment
- Neuroscience and Neural Engineering
- Bacterial Infections and Vaccines
- Nerve Injury and Rehabilitation
- Transplantation: Methods and Outcomes
- Lung Cancer Treatments and Mutations
- Muscle activation and electromyography studies
- Digital Imaging in Medicine
- Nerve injury and regeneration
- Salivary Gland Tumors Diagnosis and Treatment
- Head and Neck Cancer Studies
- Noise Effects and Management
- Lung Cancer Research Studies
- Ear Surgery and Otitis Media
- Vestibular and auditory disorders
- Conducting polymers and applications
- Neuroendocrine Tumor Research Advances
- Ear and Head Tumors
- Pulmonary Hypertension Research and Treatments
- Orthopedic Surgery and Rehabilitation
- Oral and Maxillofacial Pathology
- Effects of Radiation Exposure
- Renal Transplantation Outcomes and Treatments
University of Alabama at Birmingham
2015-2024
NatureServe
2022
Royal Victoria Eye and Ear Hospital
2021
Healthwise
2020
Cochlear (Australia)
2016-2020
University of Alabama
2018-2020
Birmingham VA Medical Center
2018-2020
The University of Melbourne
2006-2019
Guangzhou Medical University
2019
The Royal Victorian Eye & Ear Hospital
2006-2019
To monitor cochlear function during implantation and determine correlations with postoperative acoustic hearing.Cochlear response telemetry measures directly from implant electrodes. We have adapted this system to provide real-time (RT-CRT) monitoring of a patient's hearing as the electrode array is inserted.Eighteen subjects (1 child 17 adults) sloping high frequency loss were implanted Cochlear Ltd slim straight arrays (CI422/CI522). Tone bursts (500 Hz, 100-110 dB) presented at 14 Hz...
Acoustically evoked neural and hair cell potentials can be measured from the round window (RW) intraoperatively in general population of cochlear implant recipients.Cochlear performance varies greatly among patients. Improved methods to assess monitor functional substrate before during implantation could potentially aid enhanced nontraumatic intracochlear electrode placement subsequent improved outcomes.Subjects (1-80 yr) undergoing were included. A monopolar probe was placed at RW after...
Objective: A decrease in intracochlear electrocochleographic (ECochG) amplitude during cochlear implantation has been associated with poorer postoperative hearing preservation several short-term studies. Here, we relate the stability of ECochG surgery to at 3- and 12-months. Methods: Patients ≤80-dB HL 500 Hz were implanted a slim-straight electrode array. responses short, high-intensity, 500-Hz pure tones alternating polarity recorded continuously from apical-most implantation. No feedback...
Introduction: Avoidable hospital admissions put increased pressure on already strained health care resources, causing emotional and financial distress for patients their families while taxing the system. Pharmacist involvement in patient has been shown to improve outcomes. Telepharmacy allows personalized interaction access pharmacy services a flexible format. The primary aim of this report is explore impact that telepharmacy service admission rate an outpatient population before during...
An absence of dysferlin leads to activation innate immune receptors such as Toll-like (TLRs) and skeletal muscle inflammation. Myeloid differentiation primary response gene 88 (MyD88) is a key mediator TLR-dependent signalling. We hypothesized that endogenous TLR ligands released from the leaking dysferlin-deficient fibres engage TLRs on cells contribute disease progression. To test this hypothesis, we generated characterized MyD88 double-deficient mice. Double-deficient mice exhibited...
Objectives The study goals were to examine whether cochlear implantation increases the risk of meningitis in absence other factors and understand pathogenesis pneumococcal post implantation. Study Design Setting Four weeks following surgery, 54 rats (18 which received a cochleostomy alone, 18 acute using standard surgical techniques, implant) infected with Streptococcus pneumoniae via three different routes bacterial inoculation (middle ear, inner intraperitoneal) represent all potential...
Urbanchek, Melanie G. PhD; Wei, Benjamin MD; Baghmanli, Ziya Sugg, Kristoffer Cederna, Paul S. MD
Background: The goal of the authors is to restore fine motor control and sensation for high-arm amputees. They developed a regenerative peripheral nerve interface with aim attaining closed loop neural by integrating directly amputee's residual sensory nerves. PEDOT, poly(3,4-ethylenedioxythiophene), has both electrical ionic conduction characteristics. This hybrid character could help bridge salutatory nervous system an electrode. purpose this study was determine whether electrodes...
The rat is a suitable animal to establish model for the study of pneumococcal meningitis postcochlear implantation.There has been an increase in number cases cochlear implant-related meningitis. most common organism identified was Streptococcus pneumoniae. Whether implantation increases risk healthy subjects without other factors remains be determined. Previous studies do not focus on pathogenesis and postimplantation are based relatively small numbers, making it difficult assess...
The authors' goal is to develop a peripheral nerve electrode with long-term stability and fidelity for use in nerve/machine interfaces. Microelectromechanical systems silicon probes that contain multichannel actuators, sensors, electronics. authors tested the null hypothesis implantation of microelectromechanical does not have detrimental effect on function or regeneration.A rat hind-limb, peroneal model was used all experimental groups: intact (control group, n=10); division repair (repair...
Hypothesis: A minimal threshold of Streptococcus pneumoniae is required to induce meningitis in healthy animals for intraperitoneal (hematogenous), middle ear, and inner ear inoculations, this may be altered via recent surgery. Background: There has been an increase the number reported cases cochlear implant-related pneumococcal since 2002. The pathogenesis complex not completely understood. bacteria can reach central nervous system (CNS) from upper respiratory tract mucosa either...
Uninjured peripheral nerves in upper-limb amputees represent attractive sites for connectivity with neuroprostheses because their predictable internal topography allows precise sorting of motor and sensory signals. The inclusion poly(3,4-ethylenedioxythiophene) reduces impedance improves charge transfer at the biotic-abiotic interface. This study evaluates vivo performance poly(3,4-ethylenedioxythiophene)-coated interpositional decellularized nerve grafts across a critical conduction gap,...
ObjectivesTo evaluate the potential risk of pneumococcal meningitis associated with use a dexamethasone-eluting intracochlear electrode array as compared control array.MethodsIn two phases, adult Hooded–Wistar rats were implanted via middle ear an and inoculated Streptococcus pneumoniae 5 days post-surgery. Phase I created dosing curve by implanting five groups (n = 6) array, then inoculating later different numbers S. pneumoniae: 0 CFU, 103 104 CFU repeated, or 105 (colony forming units). A...
Background In sudden and asymmetrical progressive sensorineural hearing loss (SNHL), magnetic resonance imaging (MRI) is required to evaluate retrocochlear pathology and, with recent advances in MRI techniques, inner ear pathology. Given the limited literature regarding associated SNHL, we aimed assess incidence of pathology, congenital malformation on SNHL (SSNHL) SNHL. Methods A total 987 acoustic neuroma (AN) protocol internal meatus studies performed at our institution investigate...