A5084798695- Neuroinflammation and Neurodegeneration Mechanisms
- Tryptophan and brain disorders
- Alzheimer's disease research and treatments
- Stress Responses and Cortisol
- Gut microbiota and health
- Memory and Neural Mechanisms
- Peroxisome Proliferator-Activated Receptors
- Diet and metabolism studies
- Fatty Acid Research and Health
- RNA regulation and disease
- Adipokines, Inflammation, and Metabolic Diseases
- NF-κB Signaling Pathways
- Adipose Tissue and Metabolism
- CRISPR and Genetic Engineering
- Immune Response and Inflammation
- Oral microbiology and periodontitis research
- Adenosine and Purinergic Signaling
The Ohio State University
2022-2025
Institute for Behavioral Medicine
2022-2025
The Ohio State University Wexner Medical Center
2022
Alzheimer's Disease (AD) is a neurodegenerative disease characterized by profound memory impairments, synaptic loss, neuroinflammation, and hallmark pathological markers. High-fat diet (HFD) consumption increases the risk of developing AD even after controlling for metabolic syndrome, pointing to role itself in increasing risk. In AD, complement system, an arm immune system which normally tags redundant or damaged synapses pruning, becomes pathologically overactivated leading tagging healthy...
Obesity and metabolic syndrome are major public health concerns linked to cognitive decline with aging. Prior work from our lab has demonstrated that short-term high fat diet (HFD) rapidly impairs memory function via a neuroinflammatory mechanism. However, the degree which these rapid inflammatory changes unique brain is unknown. Moreover, deviations in gut microbiome composition have been associated obesity impairment, but how aging interact impact microbiome, or occur, less clear. Thus,...
A growing body of literature has identified periodontal disease among the modifiable risk factors for Alzheimer's (AD), but mechanisms underlying this relationship is unknown. This study investigated using a ligature-induced preclinical periodontitis (Pd) model in non-transgenic (non-Tg) and 3xTg-AD mice. We found that ligature placement caused significant alveolar bone loss, with mice exhibiting exacerbated suggesting AD-related genetic may amplify progression. Pd induced robust local...
The consumption of diets high in saturated fatty acids and/or refined carbohydrates are associated with neuroinflammation, cognitive dysfunction, and neurodegenerative disease. In contrast, polyunsaturated anti-inflammatory neuroprotective effects. We have previously shown that fat diet (HFD) increases decreases the hippocampus. further HFD elicits exaggerated neuroinflammation reduced synaptic elements, results robust memory deficits aged rats. Here, we examined impact palmitate, an...