A5018561560- Retinal Diseases and Treatments
- Retinal Imaging and Analysis
- Advanced Glycation End Products research
- Glaucoma and retinal disorders
- Retinal and Optic Conditions
- Intraocular Surgery and Lenses
- Biofield Effects and Biophysics
- Neurological Disorders and Treatments
- Acute Ischemic Stroke Management
- MicroRNA in disease regulation
- Ocular Diseases and Behçet’s Syndrome
- Allergic Rhinitis and Sensitization
- Atherosclerosis and Cardiovascular Diseases
- Data-Driven Disease Surveillance
- Medical Education and Admissions
- COVID-19 Clinical Research Studies
- Corneal surgery and disorders
- Diversity and Career in Medicine
- Natural Antidiabetic Agents Studies
- Reliability and Agreement in Measurement
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Otitis Media and Relapsing Polychondritis
- Cerebral Venous Sinus Thrombosis
- Diet and metabolism studies
- Inflammasome and immune disorders
Medical College and Hospital, Kolkata
2020-2023
Institute of Neurosciences Kolkata
2021
Community Link
2020
Midnapore Medical College and Hospital
2010
To compare macular thickness following uncomplicated phacoemulsification with foldable acrylic lens and manual small incision cataract surgery (MSICS) non-foldable polymethyl methacrylate (PMMA) implantation.Prospective study was carried out one eye each of 224 patients senile randomized into two groups, MSICS, by simple 1:1 randomization. Following either the methods, measured optical coherence tomography (OCT) on 1st, 7th, 42nd 180th postoperative day. Main outcome measure thickness.On...
New blood vessel formation in the retina because of prolonged hypoxia is believed to be directly associated with increased expression several growth factors and angiogenic cytokines. In present study, we made an attempt investigate possible association promoter polymorphisms interleukin 6, tumor necrosis factor α, 10 for pathogenesis proliferative diabetic retinopathy (PDR).This case-control study comprised 493 volunteers (253 PDR cases 240 controls). Cases controls were ascertained such...
Diabetic Macular Edema (DME) is a major complication of diabetic retinopathy characterized by fluid accumulation in the macula, leading to vision impairment. The standard treatment involves anti-VEGF (Vascular Endothelial Growth Factor) therapy, but approximately 36% patients do not respond adequately, highlighting need for more precise predictive models guide treatment. This study aims develop Hybrid Deep Learning model predict responses DME undergoing thereby improving accuracy planning...
Excessive intracellular glucose in insulin-independent tissues including nerve, nephron, lens, and retina invites mishandling of metabolism resulting a background increased oxidative stress, advanced glycation end products (AGE) formation, lipid peroxidation, failure antioxidant defense systems type 2 diabetes mellitus (T2DM). All these detrimental biochemical anomalies ultimately attack biological membranes especially capillary beds the retina, breakdown inner blood-retinal barrier...
The present study aimed to explore the early predictive marker of diabetic retinopathy (DR) and elucidate associated demographic, metabolic, ocular factors. We enrolled 43 type 2 subjects with mild non-proliferative (MNPDR), 30 no (DNR), 35 healthy controls (HC). groups showed significant alteration in central macular thickness (CMT) visual acuity (VA). contrast sensitivity (CS) score was found be significantly lower among DNR MNPDR compared HCs (p < 0.0001). Between subjects, CS former =...
Eales' disease (ED) is an idiopathic retinal vasculitis characterized by capillary nonperfusion and neovascularization. Previous reports on ED demonstrated that T-cell-mediated immunoresponse differential cytokine production in inflammatory angiogenic stage seem to influence the extent severity of this disease. Therefore, purpose study investigate gene polymorphisms occurrence ED.One hundred twenty-one patients with were recruited from Eastern Indian population compared 223 matched healthy...
Diabetic retinopathy (DR), the leading cause of blindness among working adults, is an urgent public health problem as diabetes mellitus (DM) increasing at alarming rate. Hyperglycemia-induced endothelial dysfunction principal contributing factor to development microangiopathy. Altered levels microRNA (miR), negative regulator protein-coding genes, have been observed and considered be markers for DR. Present study aimed find out whether miR in plasma could effective biomarkers differentiate...
In the present study, we aimed to evaluate efficacy, safety, and cost-effectiveness of anti-vascular endothelial growth factor (anti-VEGF), namely ranibizumab (RBZ) or bevacizumab (BVZ), after either focal grid scatter laser photocoagulation, for treatment diabetic macular edema (DME) in Indian population.Retrospective data were collected Regional Institute Ophthalmology, Kolkata, India between January 2018 June 2019. Seventy-seven eyes received 3 consecutive monthly intravitreal injections...
To assess the association of lipid and lipid-derived toxic molecules in pathogenesis severity diabetic retinopathy (DR) type 2 diabetes mellitus (T2DM).The present cross-sectional study included 14 healthy individuals (HC) without T2DM, 22 T2DM subjects DR (DNR), 24 with mild non-proliferative (MNPDR), high-risk proliferative (HRPDR). All underwent plasma vitreous analysis for estimation total (TL), free fatty acid (FFA), peroxides (LPOs) like malondialdehyde (MDA), 4-Hydroxy-noneal (HNE),...
To identify the distribution, differential Toll-like receptor (TLR) expression, and functional contribution of monocyte subpopulations in inflammatory stage Eales' disease (ED).Peripheral blood mononuclear cells were isolated from nine patients during ED age- sex-matched healthy controls. The expression CD14, CD16, TLR-2, TLR-4 on monocytes was measured by flow cytometry. CD14⁺, CD16⁻, CD16⁺ populations sorted basis magnetic-activated cell-sorting methodology, levels cytokines ELISA.In...
The focus is often on the best and worst eyes to detect early predictive non-invasive biomarkers of diabetic retinopathy. Typically, such data have been dealt with in a case-control setting, which applies two-sample tests ignores correlation between fellow eyes. Practitioners are mostly unaware that measurements hide labels eyes, rules out standard tools, as paired
A differential outcome in randomized controlled trials of anti-vascular endothelial growth factor (anti-VEGF) therapy, including ranibizumab, for diabetic macular edema is a major dilemma planning, optimizing, and managing clinical usage. The variable the therapeutics necessitates importance finding predictive biomarker anti-VEGF therapy to improve subject selection.Our study correlates baseline pro- isoforms its three receptors (VEGFReceptor1, VEGFReceptor2, VEGFReceptor3) circulatory...
The objectives of the study were to identify prevailing trend specialty related career choices and major factors affecting it amongst newly passed medical graduates West Bengal, India.It was a questionnaire based cross sectional study.A total 600 young doctors participated in study; out 600, 301 (50.16%) had opted for surgery allied branches whereas 273 (45.50%) medicine branches.Only 26 (4.37%) chosen pre para clinical subjects as their desired area specialization.According choice,...
Abstract Background: Persistently hyperglycemic condition in type 2 diabetic mellitus disrupts the controlled coordinated system of glucose metabolism by glycolysis and this is aggravated lipid peroxidation end products (ALEs). Purpose study to determine role advanced lipoxidation on activities hexokinase, gatekeeper enzyme lactate dehydrogenase, survival different stages retinopathy. Methods: In present study, we enrolled a total 236 consecutively selected subjects comprising 57 healthy...
The purpose of this study was to investigate the influence lunar phases on fasting plasma glucose, heart rate, and blood pressure in type 2 diabetic patients. present cross-sectional carried out during four phases, i.e., full moon (FM), first quarter (FQ), new (NM), third (TQ), month. conducted 42 randomly selected patients (22 males 20 females) from Diabetes Clinic Calcutta Medical College. Fasting glucose (FPG) each subject determined rate (HR) (BP) were measured at rest static exercise...
Excessive intracellular glucose in insulin independent tissues including nerve, nephron, lens and retina invites mishandling of metabolism resulting a background increased oxidative stress, advanced glycation end products (AGE) formation, lipid peroxidation failure antioxidant defense systems type 2 diabetes mellitus (T2DM). All these detrimental biochemical anomalies ultimately attack biological membranes especially capillary beds glomerulus kidney, break-down inner blood-retinal i.e....
It has been observed that the lunar phases alter fasting plasma glucose (FPG) level in type-2 diabetic (T2DM) subjects. Diabetic peripheral neuropathy (DPN) was also reported to be associated with elevated foot temperature (FT), oxidative stress, and inflammation T2DM subjects.The purpose of present study evaluate changes FT, levels assess relationship FT antioxidant enzyme activity, inflammatory markers subjects at different phases.The glucose, glycated hemoglobin, dorsal plantar surface...