A5027891999- CAR-T cell therapy research
- Immune Cell Function and Interaction
- Acute Lymphoblastic Leukemia research
- Immunotherapy and Immune Responses
- Acute Myeloid Leukemia Research
- CRISPR and Genetic Engineering
- RNA Interference and Gene Delivery
- Venous Thromboembolism Diagnosis and Management
- Macrophage Migration Inhibitory Factor
- Virus-based gene therapy research
- Chronic Myeloid Leukemia Treatments
- Chronic Lymphocytic Leukemia Research
- Viral Infectious Diseases and Gene Expression in Insects
- Renal and related cancers
- Intracranial Aneurysms: Treatment and Complications
- Acute Ischemic Stroke Management
- Ion channel regulation and function
Fred Hutch Cancer Center
2019-2023
University of Colorado Denver
2020
University of Washington
2020
The CBFA2T3-GLIS2 (C/G) fusion is a product of cryptic translocation primarily seen in infants and early childhood associated with dismal outcome. Here, we demonstrate that the expression C/G oncogenic protein promotes transformation human cord blood hematopoietic stem progenitor cells (CB HSPCs) an endothelial cell coculture system recapitulates transcriptome, morphology, immunophenotype acute myeloid leukemia (AML) induces highly aggressive xenograft models. Interrogating transcriptome...
Background Blunt cerebrovascular injury (BCVI) is associated with increased stroke and mortality risk. However, the most appropriate follow-up strategy remains uncertain. Purpose To better understand natural history of BCVI help define optimal timing length imaging. Materials Methods In this retrospective HIPAA-compliant study, data from all patients treated for at a level I trauma center between April 1, 2005, June 30, 2015, were reviewed. For least one time-to-event analysis was performed...
Abstract Purpose: We previously identified mesothelin (MSLN) as highly expressed in a significant fraction of acute myeloid leukemia (AML) but entirely silent normal hematopoiesis, providing promising antigen for immunotherapeutic targeting that avoids hematopoietic toxicity. Given T cells genetically modified to express chimeric receptors (CAR) are effective at eradicating relapsed/refractory lymphocytic leukemia, we developed MSLN-directed CAR preclinical evaluation AML. Experimental...
<div>AbstractPurpose:<p>We previously identified mesothelin (MSLN) as highly expressed in a significant fraction of acute myeloid leukemia (AML) but entirely silent normal hematopoiesis, providing promising antigen for immunotherapeutic targeting that avoids hematopoietic toxicity. Given T cells genetically modified to express chimeric receptors (CAR) are effective at eradicating relapsed/refractory lymphocytic leukemia, we developed MSLN-directed CAR preclinical evaluation...
<p>Supplemental Table and Figure</p>
Abstract Fusion oncoproteins are the initiating event in AML pathogenesis, although they thought to require additional cooperating mutations for leukemic transformation. CBFA2T3-GLIS2 (C/G) fusion occurs exclusively infants and is associated with highly aggressive disease 1-4 . Here we report that lentiviral transduction of C/G sufficient induce malignant transformation human cord blood hematopoietic stem progenitor cells (CB HSPCs) fully recapitulates AML. Engineered CB HSPCs co-cultured...