A5101517786- Cancer, Hypoxia, and Metabolism
- RNA Research and Splicing
- Neuroblastoma Research and Treatments
- Epigenetics and DNA Methylation
- Cancer-related Molecular Pathways
- Sarcoma Diagnosis and Treatment
- Microtubule and mitosis dynamics
- Shoulder Injury and Treatment
- Glycosylation and Glycoproteins Research
- Orthopedic Surgery and Rehabilitation
- Elbow and Forearm Trauma Treatment
- Bone fractures and treatments
- Knee injuries and reconstruction techniques
- Cell death mechanisms and regulation
- Cancer therapeutics and mechanisms
- Musculoskeletal synovial abnormalities and treatments
- RNA modifications and cancer
- Caveolin-1 and cellular processes
- Protein Degradation and Inhibitors
- Cancer, Lipids, and Metabolism
- Lung Cancer Research Studies
- Bone Tumor Diagnosis and Treatments
- Synthesis and Biological Activity
- Mitochondrial Function and Pathology
- Total Knee Arthroplasty Outcomes
Institute of Medical Sciences and Sum Hospital
2021-2024
Siksha O Anusandhan University
2020-2024
National AIDS Control Organisation
2023
Institute of Medical Sciences
2020
St. Jude Children's Research Hospital
2018-2019
Sriram Chandra Bhanja Medical College Hospital
2017
Creative Commons
2017
Scripps Research Institute
2013-2016
Jupiter Medical Center
2016
Scripps Institution of Oceanography
2011-2015
Myc oncoproteins induce genes driving aerobic glycolysis, including lactate dehydrogenase-A that generates lactate. Here, we report controls transcription of the transporter SLC16A1/MCT1 and elevated MCT1 levels are manifest in premalignant neoplastic Eμ-Myc transgenic B cells human malignancies with MYC or MYCN involvement. Notably, disrupting function leads to an accumulation intracellular rapidly disables tumor cell growth provoking marked alterations glycolytic intermediates, reductions...
The cell membrane glycolipid GD2 is expressed by multiple solid tumors, including 88% of osteosarcomas and 98% neuroblastomas. However, are highly heterogeneous, with many tumors exhibiting expression on <50% the individual cells, while some essentially GD2-negative. Anti-GD2 immunotherapy current standard care for high-risk neuroblastoma, but its application to recurrent osteosarcomas, which no effective therapies exist, has been extremely limited. This is, in part, because assays measure...
The tyrosine kinase Wee1 is part of a key cellular sensing mechanism that signals completion DNA replication, ensuring proper timing entry into mitosis. acts as an inhibitor mitotic by phosphorylating cyclin-dependent CDK1. activity mainly regulated at the protein level through its phosphorylation and subsequent degradation ubiquitin proteasome pathway. To facilitate identification small molecules preventing degradation, homogeneous cell-based assay was developed using HeLa cells transiently...
Ubiquitin mediated proteolysis is required for transition from one cell cycle phase to another. For instance, the mitosis inhibitor Wee1 targeted degradation during S and G2 allow mitotic entry. an essential tyrosine kinase G2/M S-phase progression. Although several studies have concentrated on regulation mitosis, few elucidated its interphase. Our prior demonstrated that degraded via CK1δ dependent phosphorylation phases of cycle. Here we demonstrate GSK3β may work in concert with induce...
Gln and Tyr conjugates of MCT inhibitors were designed shown to be highly cytotoxic a human cancer cell line expressing the transporters Asct2, LAT1, MCT1/2.
Background: HIV pre-exposure prophylaxis (PrEP) is part of India’s prevention policy. We aimed to determine awareness and willingness-to-use PrEP among men-who-have-sex-with-men (MSM) transgender-persons (TG) in Delhi, India. Methods: A cross-sectional study was conducted at five purposively selected targeted-intervention projects Delhi. Participants included self-identified MSM/TG aged ≥18 years, with negative/unknown serostatus. structured interview schedule, developed using formative...
The incidence of compound fractures and severe soft tissue loss has increased manifolds due to high speed traffics. Negative Pressure Wound Therapy (NPWT) is a treatment modality for managing aspect such injuries. It reduces the need flap coverage. However, many patients from developing countries cannot afford conventional NPWT. We developed an indigenous low cost NPWT our supplemented it with Topical Pressurised Oxygen (TPOT). conducted this study compare its outcome use NPWT.The was 2018...
Cobalt complex with flutamide was synthesized and physico-chemically characterized by amperometry, polarography, elemental analysis IR spectrometry.After synthesizing the metal complex, it evaluated for antibacterial antifungal activities against various pathogenic microorganisms such as Streptococcus aureus, Prosteus mirabilis, Klebsiella pneumonia Aspergillus niger, Nigrosporan sp Fungi.B16-F10 melanoma cell C-57BL/6 mice have been used anticancer screening of in vitro vivo study.The...
Background and objectives: The treatment of extra-articular distal tibia fractures is still a subject debate frequently necessitates surgical treatment, intramedullary nailing (IMN) offers minimally invasive approach with excellent results. Important factors in these procedures are positioning, operative duration, radiation exposure. This study details the semi-extended lateral para-patellar for IMN documents our findings regarding time, intra-operative exposure, residual anterior knee pain,...
First carpometacarpal (CMC) joint arthritis is a common debilitating condition affecting thumb function. Surgical management often involves trapeziectomy to alleviate pain and restore functionality. The suspensionplasty techniques maintain the trapezial height after trapeziectomy. older used help of ligamentoplasty by taking flexor carpi radialis or abductor pollicis longus. A new technique where first metacarpal suspended second means strong suture material (fiberwire) tied with button...
Purpose This study details the functional results, patient satisfaction, and cost-effectiveness of patients treated with Fisk-Fernandez surgery using iliac crest graft K-wire for scaphoid nonunion. Materials methods involved a retrospective analysis conducted between November 2022 August 2024. Forty-two diagnosed nonunion were surgical approach that included autologous bone grafting combined fixation to promote healing stability. To enable comparison, QuickDASH-9 score, visual analog scale...
Background Anterior cruciate ligament (ACL) avulsion fractures often necessitate surgical intervention, with various fixation techniques available. Among these, the arthroscopic suture pull-out technique has gained attention as a promising approach. However, influence of timing on patient outcomes remains insufficiently studied. This study aims to evaluate efficacy for ACL tibial and assess how intervention affects functional outcomes. Methodology was conducted at our hospital from November...
Distal tibial and fibular fractures are typically the result of high-energy trauma. Open reduction internal fixation (ORIF) often used to reconstruct reduce displaced fractures, especially intra-articular ones. These can be addressed either by a dual-incision approach (medial for distal tibia lateral fibula) or single-incision direct fix both fibula. The avoids injury medial soft tissues. This study was conducted compare postoperative clinico-radiological functional outcomes fractures.
This study aims to evaluate the effects of adjustable- and fixed-loop femoral endobuttons on intraoperative surgeon satisfaction postoperative patient functional outcomes in anterior cruciate ligament (ACL) reconstruction. The use cortical suspensory devices, either or adjustable-loop, is common ACL reconstruction surgeries for tunnel fixation. Fixed-loop although effective, often require additional drilling, potentially leading widening. Adjustable-loop devices were introduced mitigate this...
Intraosseous lipoma (IL) is a rare benign bone lesion, and it constitutes about 0.1% of all tumors. The majority cases are located in the metaphyseal region long bones lower limbs. We report case ilium 12-year-old male child presenting with mass over right gluteal region. Meticulous marginal dissection was done, pedunculated originating from sacroiliac excised toto. an atypical example IL large outgrowth involving inconclusive magnetic resonance imaging needle biopsy findings.
Giant cell tumor (GCT) commonly arises from epiphysis of the long bones, and most common sites for primary are distal femur, proximal tibia, humerus, radius. Patella is a very rare site development GCT. We report two cases with GCT patella. Both patients presented history intermittent right anterior knee pain swelling were treated by radical excision. In one case, temporary immobilization done arthrodesis cross K-wires followed mobilization using hinged brace.