A5021856528- Cardiac Ischemia and Reperfusion
- Organ Transplantation Techniques and Outcomes
- Transplantation: Methods and Outcomes
- Immune Response and Inflammation
- Cerebrospinal fluid and hydrocephalus
- Cardiac Structural Anomalies and Repair
- Cardiac Valve Diseases and Treatments
- Traumatic Brain Injury and Neurovascular Disturbances
- Systemic Lupus Erythematosus Research
- Complement system in diseases
- Cardiac Arrest and Resuscitation
- Cancer-related molecular mechanisms research
- Nosocomial Infections in ICU
- Pleural and Pulmonary Diseases
- Infective Endocarditis Diagnosis and Management
- Cardiac Imaging and Diagnostics
- Inflammasome and immune disorders
- Renal Transplantation Outcomes and Treatments
- Congenital Heart Disease Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Liver Disease and Transplantation
- Inflammatory Biomarkers in Disease Prognosis
- Platelet Disorders and Treatments
- Mechanical Circulatory Support Devices
Nicosia General Hospital
2020-2021
Beth Israel Deaconess Medical Center
2011-2012
University of Crete
2011-2012
Harvard University
2012
University Hospital of Heraklion
2011
The robust inflammatory response that occurs during ischemia reperfusion (IR) injury recruits factors from both the innate and adaptive immune systems. However contribution of platelets their products such as Platelet Factor 4 (PF4; CXCL4), pathogenesis IR has not been thoroughly investigated. We show a deficiency in PF4 protects mice local remote tissue damage after 30 minutes mesenteric 3 hours PF4-/- compared to control B6 mice. This protection was independent Ig or complement deposition...
Ischemia-reperfusion (I/R) injury is a leading cause of morbidity and mortality. A functional role for platelets in tissue damage after mesenteric I/R largely unknown. The hypothesis that local remote are platelet dependent was tested. Using murine model, we demonstrate orchestrate lung follows also contribute, albeit to lesser degree, villi damage. While delayed compared with damage, it increased over time characterized by accumulation the pulmonary vasculature early, followed alveolar...
Several innate and adaptive immune cell types participate in ischemia/reperfusion induced tissue injury. Amongst them, platelets have received little attention as contributors the process of damage after ischemia reperfusion (I/R) It is currently unknown whether through immunologically important molecules including, CD40 when activated, CD154 (CD40L), pathogenesis I/R We hypothesized that constitutive expression activation-induced on mediate local mesenteric remote lung Wild type (WT;...
TAVI is more frequently used to treat aortic stenosis with the mandate have a low as possible rate of adverse events. We present our 30-day outcomes and one-year mortality examine factors associated them. A prospective evaluation was performed all patients who underwent transfemoral in Nicosia General Hospital from January 2015 until March 2020. MACE were defined cardiac death, disabling stroke, and/or major vascular complications (VC). Multiple logistic Cox regression analyses identify...
Tissue injury following ischemia-reperfusion (I/R) occurs as a consequence of actions soluble factors and immune cells. Growing evidence supports role for platelets in the manifestation tissue damage I/R. Spleen tyrosine kinase has been well documented to be important lymphocyte activation more recently platelet activation. We performed experiments evaluate whether inhibition through spleen prevents after mesenteric I/R injury. Platelets isolated from C57BL/6J mice fed with R788 10 days were...
Ischemia-reperfusion (IR) injury causes a vigorous immune response that is amplified by complement activation, leading to local and remote tissue damage. Using MRL/lpr mice, which are known experience accelerated damage after mesenteric IR injury, we sought evaluate whether inhibition mitigates organ We found depletion with cobra venom factor protected mice from lung Protection was associated less (C3) membrane attack complex deposition, neutrophil infiltration, lower levels of...
Abstract Several innate and adaptive immune cell types participate in ischemia/reperfusion induced tissue injury. Amongst them, platelets have received little attention as contributors the process of damage after ischemia reperfusion (I/R) It is currently unknown whether through immunologically important molecules including, CD40 when activated, CD154 (CD40L), pathogenesis I/R We hypothesized that constitutive expression activation-induced on mediate local mesenteric remote lung Wild type...
Abstract The robust inflammatory response that takes place during ischemia reperfusion injury (IR/I) recruits factors from both the innate and adaptive immune system. However contribution of platelets their products such as Platelet Factor 4 (PF4; CXCL4), pathogenesis IR/I has not been thoroughly investigated. We show a deficiency in PF4 protects mice local remote tissue damage after 30 minutes mesenteric 3 hours PF4-/- compared to control B6 mice. This protection was independent Ig or...
Abstract Ischemia reperfusion injury is a type of seen in clinical conditions, such as trauma, hemorrhagic shock, organ transplantation, revascularization processes, and autoimmune diseases like systemic lupus erythematosus. MRL/lpr mice due to their background present with accelerated mesenteric ischemia (IR/I). To evaluate the effect complement inhibition on tissue damage after IR mice, we depleted using Cobra Venom factor (CVF) or blocked C5a receptor C5aR antagonist, performed intestinal...
We present the case of a 44-year-old woman who suffered an out hospital cardiorespiratory arrest. After six direct current shocks and 10 minutes cardiopulmonary resuscitation she had return spontaneous circulation regained consciousness. Transthoracic echocardiography showed normal left ventricular ejection fraction mildly dilated atrium. The mitral valve was thickened with myxomatous degeneration (Barlow’s disease) moderate regurgitation secondary to bi-leaflet prolapse. Cardiac...