A5035398373- Cardiac Arrest and Resuscitation
- Thermal Regulation in Medicine
- Anesthesia and Neurotoxicity Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Respiratory Support and Mechanisms
- Cardiac Ischemia and Reperfusion
- Mechanical Circulatory Support Devices
- S100 Proteins and Annexins
- Intensive Care Unit Cognitive Disorders
- Neonatal and fetal brain pathology
- Advanced Glycation End Products research
- Sepsis Diagnosis and Treatment
- Biochemical and Molecular Research
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Neurological Disorders and Treatments
- Aortic Disease and Treatment Approaches
- Veterinary Orthopedics and Neurology
- Neuroinflammation and Neurodegeneration Mechanisms
- Heart Rate Variability and Autonomic Control
- Antibiotics Pharmacokinetics and Efficacy
- Traumatic Brain Injury Research
- Glycogen Storage Diseases and Myoclonus
- Metabolism and Genetic Disorders
- Veterinary Medicine and Surgery
- Natural Products and Biological Research
Université Paris-Est Créteil
2015-2025
Inserm
2016-2025
Institut Mondor de Recherche Biomédicale
2015-2025
École Nationale Vétérinaire d'Alfort
2016-2025
Johannes Gutenberg University Mainz
2020
University Medical Center of the Johannes Gutenberg University Mainz
2020
Agence Nationale des Fréquences
2018-2019
University of Cambridge
2018
Hôpital Cochin
2016
Groupe Hospitalier Cochin - Port-Royal, Hôtel-Dieu, Broca - La Collégiale
2016
Ischemia-reperfusion injury following ST-segment-elevation myocardial infarction (STEMI) is a leading determinant of clinical outcome. In experimental models ischemia, succinate accumulation to mitochondrial dysfunction major cause ischemia-reperfusion injury; however, the potential importance and specificity in human STEMI unknown. We sought identify metabolites released from heart patients undergoing primary percutaneous coronary intervention for emergency treatment STEMI.Blood samples...
Hypothermia induced at the onset of ischemia is a potent experimental cardioprotective strategy for myocardial infarction. The aim our study was to determine whether beneficial effects hypothermia may be due decreasing mitochondria-mediated mechanisms damage that contribute pathophysiology ischemia/reperfusion injury. New Zealand male rabbits were submitted 30 min with (32 °C) by total liquid ventilation (TLV). applied during alone (TLV group), and reperfusion (TLV-IR group) normothermia...
Total liquid ventilation provides ultrafast and potently neuro- cardioprotective cooling after shockable cardiac arrest myocardial infarction in animals. Our goal was to decipher the effect of hypothermic total on systemic cerebral response asphyxial using an original pressure- volume-controlled strategy rabbits.Randomized animal study.Academic research laboratory.New Zealand Rabbits.Thirty-six rabbits were submitted 13 minutes asphyxia, leading arrest. After resumption spontaneous...
Ultrafast and whole-body cooling can be induced by total liquid ventilation with temperature-controlled perfluorocarbons. Our goal was to determine whether this afford maximal cardio- neuroprotections through rapidity when coronary occlusion is complicated cardiac arrest.Prospective, randomized animal study.Academic research laboratory.Male New Zealand rabbits.Chronically instrumented rabbits were submitted artery ventricular fibrillation. After 8 minutes of arrest, animals resuscitated a...
Total liquid ventilation (TLV) with perfluorocarbons has been shown to induce rapid protective cooling in animal models of myocardial ischemia and cardiac arrest, improved neurological cardiovascular outcomes after resuscitation. In this study, the authors hypothesized that hypothermic TLV can also limit kidney injury arrest.Anesthetized rabbits were submitted 15 min untreated ventricular fibrillation. After resuscitation, three groups eight each studied such as (1) life support plus...
BackgroundTotal liquid ventilation (TLV) of the lungs could provide radically new benefits in critically ill patients requiring lung lavage or ultra-fast cooling after cardiac arrest. It consists an initial filling with perfluorocarbons and subsequent tidal using a dedicated ventilator. Here, we propose paradigm for lung-conservative TLV pulmonary volumes below functional residual capacity (FRC).Methods findingsUsing technology, showed that perfluorocarbon end-expiratory be maintained...
Abstract Background The administration of epinephrine in the management non-traumatic cardiac arrest remains recommended despite controversial effects on neurologic outcome. use resuscitative endovascular balloon occlusion aorta (REBOA) could be an interesting alternative. aim this study was to compare these 2 strategies return spontaneous circulation (ROSC) and cerebral hemodynamics during cardiopulmonary resuscitation (CPR) a swine model arrest. Results Anesthetized pigs were instrumented...
Extracorporeal cardiopulmonary resuscitation (ECPR) is widely proposed for the treatment of refractory cardiac arrest. It should be associated with coronary angiography if artery disease suspected. However, prioritization care remains unclear in this situation. Our goal was to determine whether reperfusion instituted as soon possible such situations a pig model.Anesthetized pigs were instrumented and submitted occlusion ventricular fibrillation. After 5 minutes untreated arrest, conventional...
Patient mortality at one year reaches 90% after out-of-hospital cardiac arrest and resuscitation. Temperature management is of the main strategies proposed to improve patient outcome resuscitation preclinical studies have shown neuroprotective effects when hypothermia achieved rapidly, although underlying mechanisms not yet been elucidated. State-of-the-art brain imaging technologies can bring new insights into early cerebral events taking place post In this paper, we characterized...
Background Total liquid ventilation (TLV) has been shown to prevent neurological damage though ultrafast cooling in animal models of cardiac arrest. We investigated whether its neuroprotective effect could be explained by mitigation early inflammatory events. Methods and Results Rabbits were submitted 10 minutes ventricular fibrillation. After resuscitation, they underwent normothermic follow-up (control) or TLV hypothermia maintenance for 3 hours (TLV). Immune response, survival,...
Background High-mobility group box 1 (HMGB1) is a major promotor of ischemic injuries and aseptic inflammatory responses. We tested its inhibition on neurological outcome systemic immune response after cardiac arrest (CA) in rabbits. Methods Results After 10 minutes ventricular fibrillation, rabbits were resuscitated received saline (control) or the HMGB1 inhibitor glycyrrhizin. A sham underwent similar procedure without CA. resuscitation, glycyrrhizin blunted successive rises HMGB1,...
Abstract Background Grapiprant is a novel anti‐inflammatory drug approved for the treatment of pain associated with osteoarthritis in dogs. Objective Compare efficacy grapiprant vs meloxicam management postoperative joint Animals Forty‐eight dogs presented cranial cruciate ligament disease and treated by tibial plateau leveling osteotomy (TPLO) between May 2020 2022. Methods In this randomized, double blinded, prospective clinical trial, client‐owned naturally occurring unilateral rupture...
Brain injury is one of the most serious complications after cardiac arrest (CA). To prevent this phenomenon, rapid cooling with total liquid ventilation (TLV) has been proposed in small animal models CA (rabbits and piglets). Here, we aimed to determine whether hypothermic TLV can also offer neuroprotection mitigate cerebral inflammatory response large animals.
BACKGROUND: In animal models, whole-body cooling reduces end-organ injury after cardiac arrest and other hypoperfusion states. The benefits of in humans, however, are uncertain, possibly because detrimental effects prolonged may offset any potential benefit. Total liquid ventilation (TLV) provides both ultrafast rewarming. previous reports, with TLV potently reduced neurological experimental animals. We hypothesized that a brief period rapid rewarming via could also mitigate multiorgan...
Recent preclinical studies have shown that therapeutic hypothermia induced in less than 30 min by total liquid ventilation (TLV) strongly improves the survival rate after cardiac arrest. When lung is ventilated with a breathable perfluorocarbon liquid, inspired allows us to control efficiently cooling process of organs. While TLV can rapidly cool animals, speed humans remains unknown. The objective predict efficiency and safety ultrafast adult humans.It based on previously published thermal...
Ultrafast cooling by total liquid ventilation (TLV) provides potent cardio- and neuroprotection after experimental cardiac arrest. However, this was evaluated in animals with no initial lung injury, whereas out-of-hospital arrest is frequently associated early-onset pneumonia, which may lead to acute respiratory distress syndrome (ARDS). Here, our objective determine whether hypothermic TLV could be safe or even beneficial an aspiration-associated ARDS animal model. induced anesthetized...
Argon has been shown to prevent ischaemic injuries in several scenarios of regional ischaemia. We determined whether it could provide a systemic effect model multiorgan failure (MOF) induced by aortic cross-clamping.Anaesthetized rabbits were submitted cross-clamping (30 min) and subsequent reperfusion (300 min). They either ventilated with oxygen-enriched air throughout the protocol [fraction inspired oxygen (FiO2 ) = 30%; control group) or mixture 30% 70% argon (argon groups). In first...