Cynthia El Hedjaj

ORCID: 0000-0003-0502-4928
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Research Areas
  • Advanced Glycation End Products research
  • Cancer Research and Treatments
  • S100 Proteins and Annexins
  • Neuroinflammation and Neurodegeneration Mechanisms
  • MRI in cancer diagnosis
  • Geomagnetism and Paleomagnetism Studies
  • Cardiac Arrest and Resuscitation
  • Acute Ischemic Stroke Management
  • Radiation Therapy and Dosimetry
  • Ultrasound and Hyperthermia Applications
  • Spaceflight effects on biology
  • Traumatic Brain Injury and Neurovascular Disturbances

Alpha MOS (France)
2025

Laboratoire de Physique des 2 Infinis Irène Joliot-Curie
2025

Université Paris Cité
2025

Université Paris-Saclay
2025

Centre National de la Recherche Scientifique
2025

Inserm
2018-2023

Institut Mondor de Recherche Biomédicale
2020-2023

Université Paris-Est Créteil
2023

École Nationale Vétérinaire d'Alfort
2023

Université Paris-Sud
2020

Abstract Iron oxide nanoparticles have been proposed for magnetic hyperthermia treatment of tumors. However, efficacy depends on the injection large amounts such and equipment is costly. Here, a new thermal cancer described, in which tumor containing low concentration nonpyrogenic pure iron nanominerals coated with carboxy‐methyl‐dextran (M‐CMD), corresponding to modified magnetosomes, are exposed ultrasound. Heating PC3 prostate carcinoma cells between 43 46°C using ultrasound presence...

10.1002/adtp.202400281 article EN cc-by Advanced Therapeutics 2025-01-19

Background High-mobility group box 1 (HMGB1) is a major promotor of ischemic injuries and aseptic inflammatory responses. We tested its inhibition on neurological outcome systemic immune response after cardiac arrest (CA) in rabbits. Methods Results After 10 minutes ventricular fibrillation, rabbits were resuscitated received saline (control) or the HMGB1 inhibitor glycyrrhizin. A sham underwent similar procedure without CA. resuscitation, glycyrrhizin blunted successive rises HMGB1,...

10.1161/jaha.122.027749 article EN cc-by-nc-nd Journal of the American Heart Association 2023-02-03

Introduction: After cardiac arrest, a sepsis-like syndrome is observed and contributes to poor prognosis. Hypothesis: This could be provoked by the massive release of Damage Associated Molecular Patterns (DAMP). Our aim was investigate role High mobility group box 1 (HMGB1), well-characterized nuclear DAMP, in an experimental model arrest. Methods: Rabbits were anesthetized submitted 10 min ventricular fibrillation. resuscitation, they either received administration inhibitor HMGB1...

10.1161/circ.138.suppl_2.288 article EN Circulation 2018-11-06

Introduction: Profound immune disorders are triggered by cell death and subsequent release of danger signals after cardiac arrest (CA). Hypothesis: High mobility group box-1 (HMGB1) is one the main endogenous mediators released ischemic death. Our goal was to determine whether its inhibition could provide neuroprotection improve outcome experimental CA. Methods: After 10 min ventricular fibrillation resuscitation, rabbits either received an administration saline (CT group, n=10) or...

10.1161/circ.142.suppl_4.145 article EN Circulation 2020-11-09

You have accessJournal of UrologyProstate Cancer: Basic Research & Pathophysiology I (MP33)1 Sep 2021MP33-19 TREATMENT OF PROSTATE CANCER USING LASER-IRRADIATED MAGNETOSOMES: A PRE-CLINICAL STUDY Cynthia El Hedjaj, Eric Barret, Imene Chebbi, and Edouard Alphandery HedjajCynthia Hedjaj More articles by this author , BarretEric Barret ChebbiImene Chebbi AlphanderyEdouard View All Author Informationhttps://doi.org/10.1097/JU.0000000000002042.19AboutPDF ToolsAdd to favoritesDownload...

10.1097/ju.0000000000002042.19 article EN The Journal of Urology 2021-08-04

You have accessJournal of UrologyProstate Cancer: Basic Research & Pathophysiology I (MP33)1 Sep 2021MP33-14 EFFICACY OF LOW INTENSITY ULTRASOUND-EXPOSED MAGNETOSOMES IN THE TREATMENT PROSTATE CANCER A XENOGRAFT MURINE MODEL Cynthia El Hedjaj, Eric Barret, Imene Chebbi, and Edouard Alphandery HedjajCynthia Hedjaj More articles by this author , BarretEric Barret ChebbiImene Chebbi AlphanderyEdouard View All Author Informationhttps://doi.org/10.1097/JU.0000000000002042.14AboutPDF ToolsAdd to...

10.1097/ju.0000000000002042.14 article EN The Journal of Urology 2021-08-04
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