A5086718672- Hedgehog Signaling Pathway Studies
- Pituitary Gland Disorders and Treatments
- Multiple Sclerosis Research Studies
- Microtubule and mitosis dynamics
- RNA modifications and cancer
- interferon and immune responses
- Hip disorders and treatments
- Hip and Femur Fractures
- Systemic Lupus Erythematosus Research
- Metalloenzymes and iron-sulfur proteins
- Cerebral Venous Sinus Thrombosis
- Transcranial Magnetic Stimulation Studies
- Genomics and Rare Diseases
- Ion channel regulation and function
- Neuroscience and Neural Engineering
- Neonatal Health and Biochemistry
- Peripheral Neuropathies and Disorders
- Hepatitis B Virus Studies
- Genetics and Neurodevelopmental Disorders
- Genetic and rare skin diseases.
- Botulinum Toxin and Related Neurological Disorders
- Trace Elements in Health
- Genetic Neurodegenerative Diseases
- Methemoglobinemia and Tumor Lysis Syndrome
- Pharmacological Effects and Toxicity Studies
Great North Children's Hospital
2010-2023
Royal Victoria Infirmary
2012-2022
Newcastle University
2008-2022
Clinical Research Institute
2022
Newcastle upon Tyne Hospitals NHS Foundation Trust
2022
Botulinum neurotoxin type A (BoNT/A) paralyses muscles by blocking acetylcholine (ACh) release from motor nerve terminals. Although highly toxic, it is used clinically to weaken whose contraction undesirable, as in dystonias. The effects of an injection BoNT/A wear off after 3-4 months so repeated injections are often used. Recovery neuromuscular transmission accompanied the formation axon sprouts, some which form new synaptic contacts. However, functional importance these contacts unknown....
Iron-sulfur (Fe-S) clusters are essential cofactors for proteins that participate in fundamental cellular processes including metabolism, DNA replication and repair, transcriptional regulation, the mitochondrial electron transport chain (ETC). ISCA2 plays a role biogenesis of Fe-S recent report described subjects displaying infantile-onset leukodystrophy due to bi-allelic mutation ISCA2. We present two additional unrelated cases, provide more complete clinical description includes...
aDepartment of Paediatrics, Royal Alexandra Children's Hospital, Brighton & Sussex University Hospitals NHS Trust, bDepartment Paediatric Neurology, Great North Victoria Infirmary, Newcastle-upon-Tyne, UK Correspondence to Poothirikovil Venugopalan, MD (PAED), MRCP (UK), FRCPCH, Department Hospital Level 6, Brighton, BN2 5BE, Tel: +44 7894 537953; fax: 1273 523126; e-mail: [email protected] Received January 18, 2012 Accepted July 5,
<h3>Objectives</h3> Children with cerebral palsy are at risk of hip migration. The Cerebral Palsy Integrated Pathway (CPIP-UK) and NICE guideline (CG145) recommended that all children bilateral should have interval X-rays to monitor this. A migration index (HMI) >33% requires further assessment by paediatric orthopaedic surgeons. This service evaluation project set out review the content XR requests made paediatricians subsequent radiology reports in Newcastle area. <h3>Methods</h3>...