A5005187559- Metal complexes synthesis and properties
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Ferrocene Chemistry and Applications
- Click Chemistry and Applications
- Magnetism in coordination complexes
- Inorganic and Organometallic Chemistry
- Free Radicals and Antioxidants
- Lanthanide and Transition Metal Complexes
- Organometallic Complex Synthesis and Catalysis
- Synthesis and Biological Evaluation
- Synthesis and Reactivity of Heterocycles
- Advanced Proteomics Techniques and Applications
- Metabolomics and Mass Spectrometry Studies
- Electrochemical Analysis and Applications
- Advanced biosensing and bioanalysis techniques
- Enzyme function and inhibition
- Metal-Catalyzed Oxygenation Mechanisms
- Radiopharmaceutical Chemistry and Applications
- Porphyrin and Phthalocyanine Chemistry
- Organophosphorus compounds synthesis
- Cyclopropane Reaction Mechanisms
- Synthesis and Reactions of Organic Compounds
- Phosphorus compounds and reactions
- Catalytic Alkyne Reactions
Lomonosov Moscow State University
2017-2025
Efficient protocols for the synthesis of triphenylcyclopentadienyl rhodium halides [(1,2,4-C5Ph3H2)RhX2]2 (1a,b: X = Cl, I) starting from 1,2,4-triphenylcyclopentadiene or cyclooctadiene derivative (1,2,4-C5Ph3H2)Rh(cod) (2) were developed. Iodide abstraction 1b with thallium silver salts allowed us to prepare rhodocenium [(1,2,4-C5Ph3H2)RhCp]PF6 (3PF6) and mesitylene complex [(1,2,4-C5Ph3H2)Rh(mesitylene)](SbF6)2 (4(SbF6)2). Halides 1a,b (at 0.5 mol % loading) showed high catalytic activity...
A series of bifunctional Ru(III) complexes with lonidamine-modified ligands (lonidamine is a selective inhibitor aerobic glycolysis in cancer cells) was described. Redox properties were characterized by cyclic voltammetry. An easy reduction suggested perspective for these agents as their whole mechanism action seems to be based on activation metal atom reduction. New compounds demonstrated more pronounced antiproliferative potency than the parental drug; individual new cytotoxic cisplatin....
Platinum (II) complexes such as cisplatin among the few others are well-known and approved for clinical use anticancer metal-based drugs. In spite of their successful wide acceptance, respective chemotherapy is associated with severe side effects ability tumors to quickly develop resistance. To overcome these drawbacks novel strategy considered, which based on platinum bioactive ligands attached act in synergy further improve its pharmacological properties. Among recently introduced...
The combination of one molecule organic and metal-based fragments that exhibit antitumor activity is a modern approach in the search for new promising drugs. In this work, biologically active ligands based on lonidamine (a selective inhibitor aerobic glycolysis used clinical practice) were introduced into structure an organometallic ruthenium scaffold. Resistant to ligand exchange reactions, compounds prepared by replacing labile with stable ones. Moreover, cationic complexes containing two...
Protein quantitation in tissue cells or physiological fluids based on liquid chromatography/mass spectrometry is one of the key sources information mechanisms cell functioning during chemotherapeutic treatment. Information significant changes protein expression upon treatment can be obtained by chemical proteomics and requires analysis cellular proteomes, as well development experimental bioinformatic methods for identification drug targets. Low throughput whole proteome chromatography...
A metallacyclic maltol-tethered organometallic Ir(III) half-sandwich complex was synthesized as an analog of the ruthenium anticancer complexes (RAPTA/RAED) to evaluate its in vitro antiproliferative activity against various human cancer cell lines.
Abstract The reactivity of ylides possessing additional iodonium functionality is driven by the departure group, which generates highly reactive intermediates. scope these reactions depends on both nature reacting partner and functional groups present at ylidic center. In this study, we investigate phosphonium–iodonium ylides, where carbon atom bonded to a cyclic phenoxaphosphonium moiety various electron‐withdrawing substituents. study examines in with nitriles alkynes, continuing our...
Bexarotene-tethered RuII(arene) compounds with 1,3,5-triaza-7-phosphatricyclo[3.3.1.1]decane (PTA) were prepared as an analog of RAPTA antitumor complexes in order to evaluate their vitro antiproliferative activity against human cancer cell lines.