A5030473653- RNA Interference and Gene Delivery
- Advanced biosensing and bioanalysis techniques
- Antifungal resistance and susceptibility
- Gut microbiota and health
- Bacterial biofilms and quorum sensing
- Monoclonal and Polyclonal Antibodies Research
- RNA modifications and cancer
- Cell death mechanisms and regulation
- Nail Diseases and Treatments
- Cardiovascular Disease and Adiposity
- Microbial Metabolism and Applications
- Fungal Biology and Applications
- Escherichia coli research studies
- Antibiotic Resistance in Bacteria
- COVID-19 Clinical Research Studies
- Immunotherapy and Immune Responses
- Viral Infectious Diseases and Gene Expression in Insects
- Phytochemical compounds biological activities
- SARS-CoV-2 and COVID-19 Research
- Pancreatic and Hepatic Oncology Research
- Metabolism, Diabetes, and Cancer
- Natural Antidiabetic Agents Studies
- MicroRNA in disease regulation
- Pancreatitis Pathology and Treatment
- Diet, Metabolism, and Disease
Aja University of Medical Sciences
2020-2025
Biotechnology Research Center
2022-2025
Army Medical University
2020
Shahid Beheshti University of Medical Sciences
2019
Due to the presence of various phenolic compounds in D.sophia, this plant may have an inhibitory effect on α-Glc and ultimately diabetes control. Therefore, work aims scrutinize total phenolic, flavonoid contents, antioxidant capacity, activity aerial parts methanolic D.sophia extract. The flower extracts were selected from among for experimental study anti-diabetic effects by assays. also studied GC/MS detect compounds. contents 21.38 ± 0.93 GAE/g 96.2 0.20 QE/g, respectively. IC50 value...
Background and purpose: Aptamers, a new category of molecular probes, are overthrowing antibodies in diagnostics. However, there serious problems with using aptamers for this application including poor or non-specific binding vivo conditions. Systematic evolution is achieved through various approaches CE-SELEX Cell-SELEX, each suffering its inevitable weaknesses. The shortcomings negative selection the lengthy procedure Cell-SELEX’s main problems, while deprived native targets. Here, we...
Colorectal cancer ranks third globally among all types of cancers. Dysbiosis the gut microbiota people with CRC is one effective agents in tumorigenesis and metastasis this type cancer. The population Escherichia coli strains, a component microbiota, increased compared healthy people. So, E.coli strains isolated from these patients may have role tumorigenesis. Because most belong to B2 phylogenuetic group, there seems be linkage between bacterium components malignancy.In study, proteomic...
Fetuin-A serves a dual function; its high levels are associated with metabolic syndrome, type 2 diabetes, obesity, insulin resistance, and nonalcoholic fatty liver disease, on the other hand, it as potent inhibitor of ectopic vascular calcification. Due to opposing findings, aim current study was investigate serum fetuin-A in men coronary artery disease (CAD).In case-control study, anthropometric biochemical parameters were determined 83 (43 CAD patients 40 control subjects). At last,...
Background: Dermatophytosis is a globally distributed fungal infection. Treatment failure and relapse common in this disease. Silver nanoparticle are known for their promising antimicrobial activity. The aim of study was to determine the antifungal activity these nanoparticles against dermatophyte species. Methods: A set 30 molecularly identified dermatophytes including Trichophyton interdigitale (n=10), rubrum Epidermophyton floccosum (n=10) were used study. Green synthesized silver using...
Evaluation of Genotypic and Phenotypic Biofilm Formation by Staphylococcus aureus Isolated from Clinical Samples Their Association with Antimicrobial Resistance
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a member of the tumor factor superfamily, triggering apoptosis in malignant cell without affecting healthy cells. However, varied types cancerous cells (e.g., leukemia) show resistance to TRAIL-induced (TIA). Herein, we evaluated effect quercetin (QUE) combination with TRAIL defeat human acute myeloid leukemia KG-1 lines against TIA. Briefly, treated (50 and 250 ng/ml) QUE (100 μM) alone together. Then, expression levels...
Background: According to the World Health Organization, prevalence of colorectal cancer (CRC) is third-most common in Iran. The population Escherichia coli strains B2 phylogenetic group as one components gut microbiota increased people with CRC and can also play a role process cancerous intestinal cells or malignancy. most concern about treating infections their association multidrug resistance (MDR). Methods: In this study, stool samples 20 patients were examined for sensitivity 9...
Recombinant DNA technology plays a vital role in improving health conditions by developing new pharmaceuticals. Recently, some of the cytokines as other recombinant proteins could be produced using technology. The IL-4 allergy, autoimmunity, and cancer has been investigated. present study was aimed to clone produce Human under specific promoter Escherichia coli assessed its biological functions. designed hIL-4 gene construct artificially synthesized; subsequently, it sub cloned into...
Introduction: Fetuin-A is a glycoprotein that synthesized by liver cells. Studies have shown this hepatokine linked to various metabolic disturbances such as obesity, and diabetes. Therefore, study was designed evaluate the role of fetuin-A in pathogenesis disturbances.Methods: The present review article. terms “fetuin-A”, “diabetes”, “obesity”, “chronic kidney disease (CKD)”, “cardiovascular (CVD)”, “non-alcoholic fatty (NAFLD)”, “cancer”, “bone diseases” “metabolic disease” were used for...