A5008896722- COVID-19 Clinical Research Studies
- COVID-19 diagnosis using AI
- Infectious Diseases and Tuberculosis
- Tuberculosis Research and Epidemiology
- Pneumocystis jirovecii pneumonia detection and treatment
- Diagnosis and treatment of tuberculosis
- Long-Term Effects of COVID-19
- Amoebic Infections and Treatments
- Pneumonia and Respiratory Infections
- Radiology practices and education
- Viral-associated cancers and disorders
- Parasitic infections in humans and animals
- Radiation Dose and Imaging
- COVID-19 and healthcare impacts
- Respiratory viral infections research
- Lung Cancer Diagnosis and Treatment
- HIV-related health complications and treatments
- Congenital Anomalies and Fetal Surgery
- Radiomics and Machine Learning in Medical Imaging
- Artificial Intelligence in Healthcare and Education
- Polyomavirus and related diseases
- Machine Learning in Healthcare
- Systemic Lupus Erythematosus Research
- Cytomegalovirus and herpesvirus research
- Respiratory Support and Mechanisms
Istituto Nazionale per le Malattie Infettive Lazzaro Spallanzani
2009-2022
Istituti di Ricovero e Cura a Carattere Scientifico
2001-2021
Carlo Forlanini Hospital
2020
University Radiology
2018
Center for Prevention and Treatment of Infections
2010-2011
DNA Diagnostic (Denmark)
2009
National Institutes of Health
2001
Background The outbreak of coronavirus disease 2019 (COVID-19) has globally strained medical resources and caused significant mortality. Objective To develop validate a machine-learning model based on clinical features for severity risk assessment triage COVID-19 patients at hospital admission. Method 725 were used to train the model. This included retrospective cohort from Wuhan, China 299 hospitalised 23 December 13 February 2020, five cohorts with 426 eight centres in China, Italy Belgium...
IntroductionSeveral recent case reports have described common early chest imaging findings of lung pathology caused by 2019 novel Coronavirus (SARS-COV2) which appear to be similar those seen previously in SARS-CoV and MERS-CoV infected patients.ObjectiveWe present some remarkable the first two patients identified Italy with COVID-19 infection travelling from Wuhan, China. The follow-up X-Rays CT scans was also included, showing a progressive adult respiratory distress syndrome...
Abstract Background Remdesivir is a prodrug of the nucleoside analogue GS-441524 and under evaluation for treatment SARS-CoV-2-infected patients. Objectives To evaluate pharmacokinetics remdesivir in plasma, bronchoalveolar aspirate (BAS) CSF two critically ill COVID-19 Methods was administered at 200 mg loading dose on first day followed by 12 days 100 Blood samples were collected immediately after (C0) 1 (C1) 24 h (C24) intravenous administration 3 until 9. BAS Days 4, 7 9 from both...
Previous retrospective studies have shown that sarcopenia substantially alters the postoperative and oncological outcomes after liver resection for malignant tumors. However, evidence is limited to small with heterogeneous results lack of standardized measurements sarcopenia.To investigate role as a risk factor associated 90-day morbidity tumors.This cohort study included 234 consecutive patients undergoing tumors at San Camillo Forlanini Hospital, Rome, Italy, between June 1, 2018, December...
Tuberculosis (TB) in the elderly (>65 years old) has increasingly become a global health problem. It long been recognized that older people are vulnerable to developing tuberculosis. We retrospectively evaluated data from patients than 65 diagnosed with pulmonary TB admitted National Institute for Infectious Diseases L. Spallanzani, Rome, Italy, 1 January 2016 31 December 2019. One hundred and six consecutive were 68% reported at least one comorbidity 44% of risk-factors. Out 26 who an...
Little evidence on coronavirus disease 2019 (COVID-19) in people living with HIV (PLWH) is currently available. We reported clinical and viroimmunological data of all HIV-positive patients admitted to our center COVID-19 from March 1 May 12, 2020. Overall, five were included: virologically-suppressed antiretroviral therapy CD4+ count was greater than 350 cell/mm3 but two patients. Although had pneumonia admission, only one developed respiratory failure. Severe acute syndrome 2 (SARS-CoV-2)...
The QuantiFERON-TB Gold Plus (QFT-Plus) is a new test for latent tuberculosis infection (LTBI) diagnosis, in which has been added tube containing shorter peptides stimulating CD8 T-cells and CD4-stimulating-peptides. Measurement of alternative biomarkers to Interferon-γ (IFN-γ) QFT-Plus may improve its sensitivity. inducible protein 10 (IP-10), proposed as (TB) biomarker. We aimed evaluate the IP-10 accuracy LTBI diagnosis. was performed 36 active TB, 31 16 healthy donors (HD). detected by...
ObjectivesTo investigate the association between sex hormones and severity of coronavirus disease 2019 (COVID-19). Furthermore, associations systemic inflammation markers, viral shedding length hospital stay were studied.Design methodsThis case–control study included a total 48 male patients with COVID-19 admitted to an Italian reference hospital. The 24 cases PaO2/FiO2 <250 mmHg who needed ventilatory support during hospitalization (severe COVID-19). controls selected in 1:1 ratio, matched...
Abstract Background Computer Tomography (CT) is considered the gold standard for assessing morphological changes of lung parenchyma. Although novel CT techniques have substantially decreased radiation dose, exposure still high. Magnetic Resonance Imaging (MRI) has been established as a radiation- free alternative to several diseases, but its role in infectious diseases needs be explored further. Therefore, purpose our study was compare MRI with high resolution (HRCT) pulmonary tuberculosis....
Cystic echinococcosis (CE) is a complex disease caused by Echinococcus granulosus (E.granulosus), and its immunophatogenesis still not clearly defined. A peculiar feature of chronic CE the coexistence Th1 Th2 responses. It has been suggested that cytokines are related to resistance, whereas susceptibility chronicity. The aim this study was evaluate, multi-parametric flow cytometry (FACS), presence specific immune signatures.We enrolled 54 subjects with suspected CE; 42 them had confirmed...
We report two cases of Corona Virus Disease-19 (COVID-19) in patients with Down Syndrome (DS) and describe the identification, diagnosis, clinical course management infection. Syndrome, which is caused by trisomy 21, characterized immune dysregulation, anatomical differences upper respiratory tract higher rate comorbidities. All these risk factors can contribute to more severe presentations COVID-19 this population. It essential raise awareness relevance SARS-COV-2 infection DS patients, as...
Purpose: To analyze the vaccine effect by comparing five groups: unvaccinated patients with Alpha variant, Delta vaccinated Omicron and assessing “gravity” of COVID-19 pulmonary involvement, based on CT findings in critically ill admitted to Intensive Care Unit (ICU). Methods: Patients were selected ICU database considering period from December 2021 23 March 2022, according following inclusion criteria: proven variant infection known vaccination at least two doses chest Computed Tomography...
Purpose We analyzed the sonographic, CT, and MRI findings in acquired immune deficiency syndrome (AIDS)–related non-Hodgkin's lymphoma (NHL) of liver to evaluate role sonography diagnosis this disease. Methods retrospectively reviewed sonograms CT scans on 26 patients who had human immunodeficiency virus with lymphoma, either primary (10 cases) or secondary (16 cases), from 1992 1999. also MR images 12 patients. All pathologically proven NHL; all imaging studies were obtained within 2 weeks...
Lack of biomarkers for treatment monitoring is listed among the main requirements next generation assays, as identified globally tuberculosis (TB) researchers. In this study, we evaluated in a low TB endemic country such Italy, effect preventive therapy on results obtained QuantiFERON Plus (QFT-Plus), cohort subjects with latent infection (LTBI) and active TB. We found that significantly decreased IFN-γ values number responders to TB1- TB2- peptides stimulation both LTBI patients....
Background . Cystic echinococcosis (CE) is a chronic, clinically complex, and neglected disease. Its prevalence in Italy, country of medium to high endemicity, remains poorly defined, as notification has long ceased be mandatory. Methods We set up retrospective cohort study involving all CE patients followed at our institute between January 2005 December 2012. Demographical clinical features were recorded analyzed. Results was found 28 (64.3%), mostly Italians from the central regions (50%),...
Background: critically ill patients with SARS-CoV-2 infection present a hypercoagulable condition. Anticoagulant therapy is currently recommended to reduce thrombotic risk, leading potentially severe complications like spontaneous bleeding (SB). Percutaneous transcatheter arterial embolization (PTAE) can be life-saving in critical patients, addition medical therapy. We report major COVID-19 Italian Research Hospital experience during the pandemic, particular focus on indications and...
To investigate two commercial software and their efficacy in the assessment of chest CT sequelae patients affected by COVID-19 pneumonia, comparing consistency tools.Included study group were 120 (56 women 104 men; 61 years median age; range: 21-93 years) who underwent examinations at discharge between 5 March 2020 15 2021 again a follow-up time (3 months; range 30-237 days). A qualitative expert radiologists infectious disease field (experience least was performed, quantitative evaluation...
Hepatic tuberculosis (TB) shows non-specific symptoms, and liver imaging may provide diagnostic clues. Here we describe a series of patients with hepatic TB showing characteristic radiological findings.Single-centre retrospective evaluation diagnosed over period 16 years who underwent ultrasound, computed tomography (CT) and/or magnetic resonance (MRI). lesions were classified as miliary, nodular, serohepatic or cholangitis.Of 14 TB, five co-infected the human immunodeficiency virus. All had...