A5010640468- Nanoparticle-Based Drug Delivery
- Essential Oils and Antimicrobial Activity
- Nanoparticles: synthesis and applications
- Advanced Drug Delivery Systems
- Natural Antidiabetic Agents Studies
- Advancements in Transdermal Drug Delivery
- Drug Solubulity and Delivery Systems
- Ion Channels and Receptors
- Pharmaceutical Practices and Patient Outcomes
- Diverse Scientific Research Studies
- Complementary and Alternative Medicine Studies
- Hormonal and reproductive studies
- Ginger and Zingiberaceae research
- Reproductive Health and Technologies
- Selenium in Biological Systems
- Wound Healing and Treatments
- Curcumin's Biomedical Applications
- Gold and Silver Nanoparticles Synthesis and Applications
- Plant Pathogens and Fungal Diseases
- Edible Oils Quality and Analysis
- Public Health and Nutrition
- Ovarian function and disorders
- Computational Drug Discovery Methods
- RNA Interference and Gene Delivery
- Helicobacter pylori-related gastroenterology studies
Al-Ahliyya Amman University
2020-2025
Pharmac
2021-2024
Centre de Recherche en Sciences et Technologies de l'Information et de la Communication
2021-2022
ORCID
2021
University of Jordan
2018-2020
Al-Zaytoonah University of Jordan
2017
Cancer is considered one of the top global causes death. Natural products have been used in oncology medicine either crude form or by utilizing isolated secondary metabolites. Biologically active phytomolecules such as gallic acid and quercetin confirmed antioxidant, anti-bacterial, neoplastic properties. There an agreement that microorganisms could mediate oncogenesis alter immune system. This research project aims to develop a novel formulation co-loaded into nanoliposomes investigate...
The prevalence of juvenile obesity is increasing, reaching epidemic proportions, presenting a link not only to NAFLD (non-alcoholic fatty liver disease) but abnormal lipid profiles and enzyme abnormalities. Liver ultrasonography sensitive specific tool for the recognition NAFLD. This study aims assess association between determine other related changes in set indicators, including profile abnormalities serum transaminases. sample included 470 obese 210 non-obese individuals aged 6-16....
Abstract Nanoliposomes (NLs) are ideal carriers for delivering complex molecules and phytochemical products, but ginger by‐products, despite their therapeutic benefits, have poor bioavailability due to low water solubility stability. Crude extracts (CGEs) 6‐gingerol were individually encapsulated within NLs in vitro activity assessment. In evaluation of anti‐proliferative anti‐inflammatory properties CGE was performed on healthy human periodontal ligament (PDL) fibroblasts MDA‐MB‐231 breast...
Background: Medicinal plants have proven their value as a source of molecules with therapeutic potential, and recent studies shown that capsaicin has profound anticancer effects in several types human cancers. However, its clinical use is handicapped due to poor pharmacokinetics. This study aims enhance capsaicin’s pharmacokinetic properties by loading the molecule into nanoliposomes model testing activity. Methods: Nanoliposomes were prepared using thin-film method, characteristics examined...
Olive leaf extract is a valuable source of phenolic compounds; primarily, oleuropein (major component) and rutin. This natural olive has potential use as therapeutic agent for cancer treatment. However, its clinical application hindered by poor pharmacokinetics low stability. To overcome these limitations, this study aimed to enhance the anticancer activity stability rutin loading them into PEGylated Nano-phytosomes. The developed Nano-phytosomes exhibited favorable characteristics in terms...
Introduction This study aimed to assess the antimicrobial activity of carvacrol in combination with approved antibiotics against methicillin-resistant Staphylococcus aureus (MRSA). Carvacrol, a phenolic monoterpenoid component essential oils, has demonstrated properties gram positive and negative bacteria. The evaluated effects combined sulfamethoxazole, linezolid, minocycline, trimethoprim. Methods MRSA strain (ATCC-33591) was used, various assays, including MIC determination, checkerboard...
Dementia is a major health problem among the elderly around world; number of dementia patients, as well antidementia drugs, has been increasing in recent years. In this paper, we searched treatment guidelines, domestic and foreign literature reports past five years, summarized classification dementia, selection current pharmacotherapies evidence-based evaluation guidelines some drugs with clinical prospects to provide reference for decision-making drug therapy.
ABSTRACT This study explores novel therapeutic avenues for diabetes, a global health concern marked by elevated blood glucose levels. We investigated the anti‐diabetic potential of Gymnema Sylvestre 's bioactive compounds, including Gymnemic acid I, Stigmasterol, Deacylgymnemic acid, Beta‐Amyrin acetate, Longispinogenin, II, X, Gymnemaside VI, Phytic and X. Employing network pharmacology, molecular docking dynamics (MD), we elucidated mechanism action. SwissTargetPrediction identified...
Background: This study aims to enhance the delivery of polyphenols using nanotechnology. Objective: To develop and evaluate liposomal formulations for improved stability polyphenols, specifically focusing on Rutin. Methods: Liposomal were meticulously prepared via Thin-Film Hydration method. Comprehensive physical characterization was conducted, including assessments Dynamic Light Scattering (DLS) Thermogravimetric Analysis (TGA). The free radical scavenging activity measured DPPH• assay,...
Doxorubicin (DOX) is a potent chemotherapeutic agent for breast cancer, but its effectiveness often diminished by resistance mechanisms, particularly through p-glycoprotein (P-gp) mediated drug efflux. Clarithromycin (CAM), macrolide antibiotic, inhibits multiple metabolic pathways including CYP3A and P-gp, potentially countering DOX resistance. This study aimed to evaluate the potentiation of against MCF-7 cancer cell line encapsulating both CAM in PEGylated liposomes. liposomes containing...
Aims This study investigates the potential effects of essential oils (EOs) in enhancing efficacy clindamycin against Methicillin-resistant Staphylococcus aureus (MRSA) using vitro and computer simulations. The research seeks to identify that exhibit synergistic activity with determine their key active components.
Hyperpigmentation is a prevalent and notable skin issue affecting individuals across all types. Although several depigmentation agents are available to address hyperpigmentation, their effectiveness limited due inadequate absorption considerable toxicity, which can lead side effects like irritative dermatitis, redness, itching, peeling skin. Nanotechnology pivotal in advancing cosmetic formulations by enhancing drug solubility, stability, safety, payload efficiency, permeability. This study...
ABSTRACT The most critical challenges confronting humanity's future is climatic change, water scarcity, and the impending end of petroleum era are primarily driven by depletion fossil fuel reserves, rising global temperatures, rapid growth population. Bio‐resources have emerged as a promising alternative for reducing dependence on petroleum‐derived materials. Interestingly, plants microbes collectively account approximately 99% Earth's total living biomass. scientific interest in...
The abstract discusses the development of rutin-loaded nanoliposomes and their anti-colorectal cancer activity against human carcinoma cells (HT-29). study characterizes using thin-film hydration method analyzes size, charge, polydispersity index. encapsulation efficiency drug loading ability rutin at different concentrations were investigated. found to be stable for up one month 4 °C showed sustained release 24 h. anti-cancer was concentration-dependent significantly improved compared free...
The synthesis of reliable biological nanomaterials is a crucial area study in nanotechnology. In this study, Emericella dentata was employed for the biosynthesis AgNPs, which were then combined with synthesized biochar, porous structure created through biomass pyrolysis. synergistic effects AgNPs and biochar evaluated assessment pro-inflammatory cytokines, anti-apoptotic gene expression, antibacterial activity. Solid biosynthesized by XRD SEM, SEM images revealing that most ranged from 10 to...
Background: Nutrients are widely used for treating illnesses in traditional medicine. Ginger has long been folk medicine to treat motion sickness and other minor health disorders. Chronic non-healing wounds might elicit an inflammation response cancerous mutation. Few clinical studies have investigated 6-gingerol’s wound-healing activity due its poor pharmacokinetic properties. However, nanotechnology can deliver 6-gingerol while possibly enhancing these Our study aimed develop a...