A5022011933- Health, Medicine and Society
- Pharmacological Effects and Toxicity Studies
- Face Recognition and Perception
- Diet and metabolism studies
- Cutaneous lymphoproliferative disorders research
- Pharmacogenetics and Drug Metabolism
- Inflammatory Biomarkers in Disease Prognosis
- Healthcare Systems and Practices
- Angiogenesis and VEGF in Cancer
- Aging, Elder Care, and Social Issues
- Genetic and rare skin diseases.
- Pituitary Gland Disorders and Treatments
- Extracellular vesicles in disease
- Peripheral Artery Disease Management
- Medical History and Innovations
- Oral Health Pathology and Treatment
- Chemotherapy-induced cardiotoxicity and mitigation
- Cardiovascular Syncope and Autonomic Disorders
- Aging, Health, and Disability
- Acute Myeloid Leukemia Research
- Therapeutic Uses of Natural Elements
- Cardiac Imaging and Diagnostics
- Epilepsy research and treatment
- Lipoproteins and Cardiovascular Health
- Drug Transport and Resistance Mechanisms
Hôpital Riviera-Chablais
2024
Hôpital du Valais
2018-2021
Hôpital Orthopédique de la Suisse Romande
2010-2011
Hôpital Lariboisière
2007
Inserm
2007
Swiss Continence Foundation
2005
A large interindividual variability in plasma concentrations has been reported patients treated with donepezil, the most frequently prescribed antidementia drug. We aimed to evaluate clinical and genetic factors influencing donepezil disposition a patient population recruited from naturalistic setting.A pharmacokinetic study was performed including data 129 older donepezil. The were genotyped for common polymorphisms metabolic enzymes CYP2D6 CYP3A, electron transferring protein POR nuclear...
To evaluate whether cisplatin-induced stroke is mediated by vascular toxicity with release of prothrombotic endothelial and platelet-derived microparticles (MPs).Endothelial (CD31(+)CD41(-)), platelets (CD31(+)CD41(+)) (Annexin V(+)) circulating MPs were quantified flow cytometry in 18 patients cancer, before 3 days after administration cisplatin, compared healthy controls. Thrombin-antithrombin complex prothrombin fragments (F(1+2)) measured as markers the activation coagulation.In baseline...
The frequently prescribed antidementia drug galantamine is extensively metabolized by the enzymes cytochrome P450 (CYP) 2D6 and CYP3A a substrate of P-glycoprotein. We aimed to study relationship between genetic variants influencing activity these transporters with steady state plasma concentrations.In this naturalistic cross-sectional study, 27 older patients treated were included. genotyped for common polymorphisms in CYP2D6, CYP3A4/5, POR, ABCB1, concentrations determined.The CYP2D6...
Background Improved endothelial function may contribute to the beneficial effects of cholesterol lowering therapy in patients with coronary artery disease (CAD), but results effect statin on are disparate these patients. Exercise training has been reported improve at risk or established CAD. The goal study was compare mild exercise forearm CAD average levels. Design and methods Twenty-eight sedentary male angiographically documented pretreatment total plasma levels (5.1±0.9 mmol/l) aged...
The goals of this exploratory pre-post pilot and feasibility study (NCT04916964) were to assess the effectiveness an adapted Test-and-Exercise home-based exercise program on basic functional mobility executive functions in persons with prodromal or mild Alzheimer's disease. Participants followed 8 week at home, once per a physiotherapist twice their usual caregiver independently. Functional assessed before after intervention. Feasibility criteria recruitment opportunity, participation...
Objectives and Design -This case report describes the disturbing symptom of mirror selfmisperception, a delusion known as Capgras syndrome.Setting Participant -A video recording captures confusion demented patient who does not recognize himself in his reflected image, instead perceives that he is looking at an identical "twin brother".