A5022265776- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Crystallography and molecular interactions
- Catalytic Alkyne Reactions
- Axial and Atropisomeric Chirality Synthesis
- Chemical synthesis and alkaloids
- Oxidative Organic Chemistry Reactions
- Synthetic Organic Chemistry Methods
Universitat Rovira i Virgili
2019-2023
Institut Català d'Investigació Química
2019-2023
Chiral gold(I) catalysts have been designed based on a modified JohnPhos ligand with distal C2-2,5-diarylpyrrolidine that creates tight binding cavity. The C2-chiral element is close to where the C–C bond formation takes place in cyclizations of 1,6-enynes. These chiral mononuclear applied for enantioselective 5-exo-dig and 6-endo-dig cyclization different 1,6-enynes as well first total synthesis three members carexane family natural products. Opposite enantioselectivities achieved seemingly...
A new generation of chiral gold(I) catalysts based on variations complexes with JohnPhos-type ligands a remote C2-symmetric 2,5-diarylpyrrolidine have been synthesized different substitutions at the top and bottom aryl rings: from replacing phosphine by N-heterocyclic carbene (NHC) to increasing steric hindrance bis- or tris-biphenylphosphine scaffolds, directly attaching C2-chiral pyrrolidine in ortho-position dialkylphenyl phosphine. The tested intramolecular [4+2] cycloaddition...
A new generation of chiral gold(I) catalysts based on variations complexes with JohnPhos-type ligands a remote C2-symmetric 2,5-diarylpyrrolidine have been synthesized different substitutions at the top and bottom aryl rings: from replacing phosphine by N-heterocyclic carbene (NHC), to increasing steric hindrance bis- or tris-biphenylphosphine scaffolds, directly attaching C2-chiral pyrrolidine in ortho-position dialkylphenyl phosphine. The cata-lysts tested intramolecular [4+2]...