A5009513481- Cervical Cancer and HPV Research
- Nutrition and Health in Aging
- Obesity, Physical Activity, Diet
- Cardiovascular Disease and Adiposity
- Cardiovascular Health and Disease Prevention
- Nutritional Studies and Diet
- Global Cancer Incidence and Screening
- Health and Lifestyle Studies
- Vaccine Coverage and Hesitancy
- Colorectal Cancer Screening and Detection
- Physical Activity and Health
- Public Health Policies and Education
- Insurance, Mortality, Demography, Risk Management
- Cardiovascular Health and Risk Factors
- Hepatitis Viruses Studies and Epidemiology
- Bone health and osteoporosis research
- Biomedical Ethics and Regulation
- Colorectal and Anal Carcinomas
- Genital Health and Disease
- Trauma and Emergency Care Studies
- Emergency and Acute Care Studies
- Ethics in Clinical Research
- Health Systems, Economic Evaluations, Quality of Life
- Primary Care and Health Outcomes
- Obstructive Sleep Apnea Research
University of Pittsburgh
2021-2025
University of Puerto Rico, Medical Sciences Campus
2018-2022
University of Puerto Rico System
2017
ABSTRACT Objective Skeletal muscle fat infiltration (myosteatosis) increases with age and is an emerging risk factor for dementia. We aimed to determine the association between myosteatosis cognitive decline among middle-aged White Black Americans. Methods Data were on men (n=1,080; 41.9% Black) women (n=1,432; 49.0% from CARDIA study. CT-measured abdominal intermuscular (IMAT) volume was assessed at baseline. Cognition by Digit Symbol Substitution (DSST), Rey Auditory Verbal Learning...
As with much of medicine, racial health disparities exist in the care patients obstructive sleep apnea (OSA). These impact all aspects from screening and diagnosis to treatment long-term management. Substantial barriers for Black other historically marginalized groups US obtain evaluation OSA, exacerbated by knowledge deficits about OSA. result disease severity being greater at time clinical diagnosis. Many diagnostic tools used OSA were adopted based on their utility White populations...
Emerging evidence suggests a potential relationship between sleep and cardiac abnormalities, even in the absence of apnea. Therefore, we aimed to test association duration structure function as assessed by echocardiography African Caribbeans aged 50-80 years from Tobago Heart Study (THS). Between 2021-2024, participants without history heart failure underwent clinical examinations, 4 7-day actigraphy-based assessment, transthoracic (preliminary analysis 401 with all measures)....
Abstract Background: The Center to Reduce Cancer Health Disparities (CRCHD), National Institute (NCI), launched Screen Save, NCI's Colorectal Outreach and Screening Initiative promote awareness knowledge of colorectal cancer in racial/ethnic rural populations. Methods: initiative was implemented through CRCHD's Network (NON) Comprehensive Partnerships Advance Equity (CPACHE) programs. NON is a national network Community Educators (CHEs), aligned with NCI-designated Centers (CCs). CPACHE are...
Skeletal muscle adiposity (myosteatosis) is recognized as a major risk factor for cardiometabolic diseases, and it increases with aging. The relationship of myosteatosis cognitive impairment unknown.
The aim of the study was to estimate magnitude association between HPV-related gynecological neoplasms and secondary anal cancer among women in Puerto Rico (PR).We identified 9,489 who had been diagnosed with a primary cervical, vaginal, or vulvar tumor during 1987-2013. To describe trends invasive vulvar, cancer, age-adjusted incidence rates were estimated using direct method (2000 US as Standard Population). Standardized ratios (observed/expected) computed indirect method; expected cases...
This study evaluates the epidemiology of nonfatal head injuries among children aged 1 to 4 years associated with consumer products and identifies specific these injuries. Data for who presented emergency departments (EDs) from 2015 2019 a injury were extracted National Electronic Injury Surveillance System. An estimated 032 429 (95% confidence interval [CI]: 675 822-1 389 063) US EDs injuries, averaging 566 daily. The average rate did not change over 5-year period (slope = -0.003;
The aim of this study was to determine whether displacement sedentary time with activity cross-sectionally associated less adiposity among Black Caribbean men in the Tobago Health Study.Objectively assessed categorized as (< 1.5 metabolic equivalents; METs), light (≥ < 3.0 or moderate-to-vigorous METs) using SenseWear Pro armband. Computed tomography scans chest, abdomen, liver, and thigh were used assess subcutaneous ectopic adipose tissue. isotemporal substitution framework paired linear...
Introduction: Alcohol intake and ectopic fat are associated with cardiometabolic diseases. While previous studies primarily focused on visceral and/or liver fat, few to date have investigated the associations of alcohol skeletal muscle infiltration, a depot which might contribute increased risk diabetes hypertension in African ancestry populations. Methods: (drinks/day) was assessed using 146-item semi-quantitative food frequency questionnaire Tobago Health Study (N=800). Ectopic measured...
Introduction: Skeletal muscle adipose tissue infiltration (i.e. myosteatosis) increases with age and is considered a significant risk factor for cardio-metabolic diseases. Emerging data hint at its role in cognitive decline, but largely from cross-sectional studies White populations. Longitudinal including Black populations, who have higher of both myosteatosis Alzheimer’s Disease related dementias than Whites, are warranted. Aim: Determine the association between abdominal function cohort...
Abstract The role of myosteatosis in cognitive decline is largely from cross-sectional studies White populations. Longitudinal including Black populations, who have a higher risk both and dementia than Whites, are warranted. We tested the association between abdominal with 5-year change cognition 2,501 American men (n=1,078; 42% Black) women (n=1,423; 49% Coronary Artery Risk Development Young Adults (CARDIA), whether associations vary after adjustment for demographics, center, education,...
Abstract From 2010-2014, colorectal cancer (CRC) was the second highest incident and leading cause of cancer-related deaths in Puerto Rico (PR). Although preventable through screening treatment, (CRCS) using fecal occult blood test (FOBT) or colonoscopy remains low for adults PR. Data from 2016 Behavioral Risk Factor Surveillance System indicated that 18.0% PR population aged 50 to 75 had undergone an FOBT within past year compared 8.0% United States (US). Additionally, 50.1% age-eligible...
Introduction: Skeletal muscle adipose tissue infiltration (i.e. myosteatosis) increases with aging, and is recognized as a major risk factor for cardio-metabolic diseases. While it known that visceral adiposity related to dementia cognitive decline, the relationship between myosteatosis cognition not well understood. Such studies are particularly needed among African ancestry women, who have greater higher burden of Alzheimer’s Disease Related Dementias compared White women. Aim: The...
Introduction: Ectopic fat is an established risk factor for cardiometabolic disorders. Few studies have examined the associations between objectively measured physical activity and ectopic depots, with mixed results. Here, we sought to use Isotemporal Substitution Framework cross-sectionally model displacement of sedentary time determine its association simultaneously depots among Black Caribbean men from Tobago Health Study. Hypothesis: Replacing will be associated less abdominal...
Introduction: Sleep efficiency (or sleep continuity, i.e., a ratio of time spent sleeping to in bed), is inversely associated with hypertension, impaired glucose metabolism, CVD risk, and mortality risk. Prolonged sedentary behavior physical activity are independently efficiency. However, it not well documented how substituting affects efficiency, especially among African-ancestry populations, who at high risk for CVD. Aim: To determine if displacement was cross-sectionally higher African...
Abstract Skeletal muscle fat infiltration (myosteatosis) leads to poorer quality and function with aging, is emerging as a predictor of skeletal strength, mobility, metabolic disorders. Few studies investigated the association physical activity (PA) sedentary behavior (SB) myosteatosis, especially in African Caribbeans, vastly under-studied, rapidly growing population. We examined associations objectively measured PA SB (Bodymedia SenseWear Armbands) worn over 7 days calf density (mg/cm3),...
Abstract Objective: This study aimed to: 1) describe age-adjusted incidences for invasive cervical, vulvar, vaginal, and anal cancer cases reported from 1987 to 2013 in Puerto Rico (PR); 2) estimate the Standardized Incidence Ratio (SIR) of secondary among women with HPV-related gynecological neoplasms (cervical, vulvar or vaginal) during 1987-2013; 3) magnitude these associations, adjusting age. Methods: We identified 9,489 who had been diagnosed a primary vaginal tumor 1987-2013 PR. To...
Abstract Introduction: Colorectal cancer (CRC) represents the second highest incidence in both men and women Puerto Rico (PR). This is leading cause of death PR. Although largely preventable through screening treatment precancerous polyps, colorectal (CRCS) using fecal occult blood test (FOBT), sigmoidoscopy, or colonoscopy remains low for adults Data from 2014 Behavioral Risk Factor Surveillance System indicate that only 18.5% PR population 50+ years has undergone an FOBT within past two...
Abstract Introduction: Colorectal cancer (CRC) is the second-highest incident among men and women in Puerto Rico (PR); however, CRC screening (CRCS) rates remain low. Data from 2014 Behavioral Risk Factor Surveillance System indicate that only 18.5% of PR population 50+ years has undergone an FOBT within past two compared to 12.8% United States America (USA). Additionally, 50.6% age-eligible Ricans report ever having a sigmoidoscopy or colonoscopy 68.8% USA. At national level, goal...
Abstract Objective Skeletal muscle adiposity (SMA) increases with aging and is recognized as a major risk factor for cardiometabolic diseases, disability, mortality among older adults. Obesity related to dementia cognitive decline yet the relationship between SMA cognition remains ill defined. The objective of this study was assess function African Caribbean women.Design Methods Cross-sectional analysis 448 women in Tobago Health Study (mean age, 55 years; range, 39-84 years). Cognition...
Introduction: Skeletal muscle is the largest organ in human body and vital to maintaining metabolic homeostasis. Increased skeletal fat infiltration (i.e. myosteatosis) now recognized as a major risk factor for cardio-metabolic diseases, independent of general obesity. Modifications lifestyle, such sleep, reduce myosteatosis would be great public health importance. However, studies this relationship often use subjective data are lacking minority populations. The aim study was examine...