A5047400358- Alzheimer's disease research and treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Neuroscience and Neuropharmacology Research
- Tryptophan and brain disorders
University of California, Irvine
2019
Long-term potentiation (LTP) is an activity-dependent and persistent increase in synaptic transmission. Currently available techniques to measure LTP are time-intensive require highly specialized expertise equipment, thus not well suited for screening of multiple candidate treatments, even animal models. To expand facilitate the analysis LTP, here we use a flow cytometry-based method track chemically induced by detecting surface AMPA receptors isolated synaptosomes: fluorescence...
Alzheimer's disease (AD), the most common age-related neurodegenerative disorder, is currently conceptualized as a of synaptic failure. Synaptic impairments are robust within AD brain and better correlate with dementia severity when compared other pathological features disease. Nevertheless, series events that promote failure still remain under debate, potential triggers such β-amyloid (Aβ) can vary in size, configuration cellular location, challenging data interpretation causation studies....