A5081863789- Bariatric Surgery and Outcomes
- Diet and metabolism studies
- Diabetes Treatment and Management
- Esophageal and GI Pathology
- Hernia repair and management
- Intestinal and Peritoneal Adhesions
- Hip and Femur Fractures
- Appendicitis Diagnosis and Management
- Diverticular Disease and Complications
- Colorectal Cancer Surgical Treatments
- Clinical Nutrition and Gastroenterology
- Anorectal Disease Treatments and Outcomes
- Gallbladder and Bile Duct Disorders
- Orthopaedic implants and arthroplasty
- Minimally Invasive Surgical Techniques
- Respiratory Support and Mechanisms
- Tendon Structure and Treatment
- Orthopedic Infections and Treatments
- Plant and Fungal Interactions Research
- Colorectal and Anal Carcinomas
- Regulation of Appetite and Obesity
- Orthopedic Surgery and Rehabilitation
- Musculoskeletal synovial abnormalities and treatments
- Bone Tumor Diagnosis and Treatments
- Bone fractures and treatments
Zealand University Hospital
2021
Hvidovre Hospital
1991-2020
Zealand University Hospital Køge
2014-2018
University of Copenhagen
1985-2016
Copenhagen University Hospital
2010-2014
Bispebjerg Hospital
2000
Svendborg Sygehus
1994-1996
Radiometer (Germany)
1991
Odense University Hospital
1991
Rigshospitalet
1991
Our aim was to study the potential mechanisms responsible for improvement in glucose control Type 2 diabetes (T2D) within days after Roux-en-Y gastric bypass (RYGB). Thirteen obese subjects with T2D and twelve matched normal tolerance (NGT) were examined during a liquid meal before (Pre), 1 wk, 3 mo, yr RYGB. Glucose, insulin, C-peptide, glucagon-like peptide-1 (GLP-1), glucose-dependent-insulinotropic polypeptide (GIP), glucagon concentrations measured. Insulin resistance (HOMA-IR), β-cell...
β-Cell function improves in patients with type 2 diabetes response to an oral glucose stimulus after Roux-en-Y gastric bypass (RYGB) surgery. This has been linked the exaggerated secretion of glucagon-like peptide 1 (GLP-1), but causality not established. The aim this study was investigate role GLP-1 improving β-cell and tolerance regulating glucagon release RYGB using exendin(9-39) (Ex-9), a receptor (GLP-1R)-specific antagonist. Nine were examined before week 3 months Each visit consisted...
Roux-en-Y gastric bypass (RYGB) improves glycemic control within days after surgery, and changes in insulin sensitivity β-cell function are likely to be involved. We studied 10 obese patients with type 2 diabetes (T2D) glucose-tolerant subjects before 1 week, 3 months, year RYGB. Participants were included a preoperative diet-induced total weight loss of -9.2 ± 1.2%. Hepatic peripheral assessed using the hyperinsulinemic- euglycemic clamp combined glucose tracer technique, was evaluated...
Roux-en-Y gastric bypass (RYGB) causes extensive changes in gastrointestinal anatomy and leads to reduced appetite large weight loss, which partly is due an exaggerated release of anorexigenic gut hormones.To examine whether the altered passage foods through tract after RYGB could be responsible for hormone release, we studied motility with a scintigraphic technique as well secretion hormones glucagon-like peptide (GLP)-1 YY3-36 (PYY3-36 ) 17 patients>1 year nine healthy control subjects.At...
OBJECTIVE To examine after gastric bypass the effect of peroral versus gastroduodenal feeding on glucose metabolism. RESEARCH DESIGN AND METHODS A type 2 diabetic patient was examined consecutive days 5 weeks bypass. standard liquid meal given first day into bypassed remnant and second perorally. Plasma glucose, insulin, C-peptide, glucagon, incretin hormones, peptide YY, free fatty acids were measured. RESULTS Peroral reduced 2-h postprandial plasma (7.8 vs. 11.1 mmol/l) incremental area...
Roux-en-Y gastric bypass (RYGB) improves glucose tolerance and ameliorates fasting hyperinsulinemia within days after surgery. Improvements in hepatic insulin sensitivity clearance could contribute importantly to these effects.The objective of the investigation was study changes RYGB.This a prospective and, subgroup patients, postprandial meal test before 1 week, 3 months, year RYGB.The conducted at Hvidovre Hospital (Hvidovre, Denmark).Patients included 2 groups obese RYGB-patients: 1) type...
Abstract Background Internal herniation is a well known and potentially life-threatening complication of laparoscopic Roux-en-Y gastric bypass (LRYGB). The aim this study was to evaluate the benefit harm closing mesenteric defects with clips during LRYGB prevent internal herniation. Methods This single-centre, single-blinded RCT. Patients eligible for were randomized surgery or without closure clips. primary endpoint incidence (intermittent) after minimum follow-up 24 months. Secondary...
To investigate the incidence of glove perforations during various types gastrointestinal surgery, to record blood contamination hands, and evaluate protective effect double gloving. Randomised prospective trial. University hospital, Denmark. 566 pairs gloves tested on surgeons, assistants, scrub nurses. The participants were allocated wear either single or Indicator gloves. number hands. perforation rate in was 53/306 (17%), that both outer inner at corresponding sites 6/260 (2%) (p <...
The aim of this study was to investigate the approach (open or laparoscopic) and mesh type (synthetic biological) in ventral hernias a clean setting.Summary Background Data: level evidence on optimal surgical hernia repair is still low.Patients with abdominal (diameter 4-10 cm) were included double-blind randomized controlled trial across 17 hospitals 10 European countries. According 2 × 2-factorial design, patients allocated 4 arms retromuscular laparoscopic intraperitoneal, synthetic...
A case of isolated avulsion the popliteus tendon in a 20-year-old male athlete is reported. The was caused by forward gliding femur on fixed tibia which produced chondral fracture and hemar throsis.
Objective The positive metabolic outcome of Roux-en-Y gastric bypass (RYGB) surgery may involve fibroblast growth factor 21 (FGF21), in both the fasting state and postprandially. We measured levels FGF21 before after bariatric as well postprandial responses a glucose load mixed meal. Design Observational intervention trial. Patients measurements Eight obese, nondiabetic patients underwent RYGB. Plasma was on three different days during oral loads (25 g or 50 glucose) Blood samples were taken...
Despite substantial research efforts, the mechanisms proposed to explain weight loss after gastric bypass (RYGB) and sleeve gastrectomy (SL) do not large individual variation seen these treatments. A complex set of factors are involved in onset development obesity may also be relevant for understanding why success with treatments vary considerably between individuals. This calls explanatory models that take into account only biological determinants but behavioral, affective contextual...
Purpose: We aimed at identifying patient characteristics associated with successful outcomes of bariatric surgery. Methods: From January 25, 2007, to 30, 2008, we consecutively enrolled patients referred a Copenhagen hospital for used the Health Related Quality Life Questionnaire Short Form-36 Survey (SF-36) and Moorehead-Ardelt II (M-A QolQII). A outcome was defined as ≥50% excess weight loss (EWL) 12 months after Data were collected baseline 6 Results: 100 101 eligible patients, which 89...