Hanna M. Hulshof
A5059140601- Tuberous Sclerosis Complex Research
- Polyomavirus and related diseases
- Genetic and Kidney Cyst Diseases
- Tumors and Oncological Cases
- Infectious Diseases and Tuberculosis
- Spinal Hematomas and Complications
- Head and Neck Surgical Oncology
- Spine and Intervertebral Disc Pathology
- Neurofibromatosis and Schwannoma Cases
- Renal and related cancers
University Medical Center Utrecht
2016-2025
Children's Memorial Health Institute
2022
ERN GUARD-Heart
2021
St. Antonius Ziekenhuis
2013
Objective Epilepsy develops in 70 to 90% of children with tuberous sclerosis complex (TSC) and is often resistant medication. Recently, the concept preventive antiepileptic treatment modify natural history epilepsy has been proposed. EPISTOP was a clinical trial designed compare versus conventional TSC infants. Methods In this multicenter study, 94 infants without seizure were followed monthly video electroencephalography (EEG), received vigabatrin either as treatment, started after first...
Tuberous Sclerosis Complex (TSC) is a genetic hamartoma syndrome frequently associated with severe intractable epilepsy. In some TSC patients epilepsy surgery promising treatment option provided that the epileptogenic zone can be precisely delineated. brain lesions (cortical tubers) contain dysmorphic neurons, brightly eosinophilic giant cells and white matter alterations in various proportions. However, histological classification system has not been established for tubers. Therefore, aim...
Autism spectrum disorder (ASD) is highly prevalent in subjects with Tuberous Sclerosis Complex (TSC), but we are not still able to reliably predict which infants will develop ASD. This study aimed identify the early clinical markers of ASD and/or developmental delay (DD) an diagnosis TSC. We prospectively evaluated 82 TSC (6-24 months age), using a detailed neuropsychological assessment (Bayley Scales Infant Development-BSID, and Diagnostic Observation Schedule-ADOS), context EPISTOP...
To correlate fetal brain magnetic resonance imaging (MRI) findings with epilepsy characteristics and neurodevelopment at 2 years of age in children tuberous sclerosis complex (TSC) to improve prenatal counseling.This retrospective cohort study was performed a collaboration between centers the EPISTOP consortium. We included definite TSC, MRIs, available follow-up data age. A pediatric neuroradiologist masked patient's clinical evaluated all MRIs. MRIs were categorized for each 10 lobes as...
<h3>Background and Objectives</h3> Multiple factors have been found to contribute the high risk of epilepsy in infants with tuberous sclerosis complex (TSC), including evolution EEG abnormalities, <i>TSC</i> gene variant, MRI characteristics. The aim this prospective multicenter study was identify early biomarkers TSC aged <6 months before seizure onset, associate these neurodevelopmental outcomes at 2 years age. part EPISTOP project. <h3>Methods</h3> We evaluated brain MRIs performed...
Abstract Objective Patients with tuberous sclerosis complex (TSC) present drug‐resistant epilepsy in about 60% of cases, and evaluation for surgery may be warranted. Correct delineation the epileptogenic zone (EZ) among multiple dysplastic lesions on MRI represents a challenging step pre‐surgical evaluation. Methods Two experienced neuroradiologists evaluated pre‐ post‐surgical MRIs 28 patients TSC, assessing characteristics tubers, cysts, calcifications, focal cortical dysplasia...
Abstract Objective Previous retrospective studies have reported vigabatrin‐associated brain abnormalities on magnetic resonance imaging (VABAM), although clinical impact is unknown. We evaluated the association between vigabatrin and predefined (MRI) changes in a large homogenous tuberous sclerosis complex (TSC) cohort assessed to what extent VABAM‐related symptoms were TSC infants. Methods The Dutch Registry EPISTOP provided prospective data from 80 patients treated with (VGB) before age of...