A5019772618- Cancer Genomics and Diagnostics
- Gut microbiota and health
- MicroRNA in disease regulation
- Genomic variations and chromosomal abnormalities
- RNA modifications and cancer
- Renal cell carcinoma treatment
- BRCA gene mutations in cancer
- RNA Research and Splicing
- DNA Repair Mechanisms
- Epigenetics and DNA Methylation
- Dermatology and Skin Diseases
- CRISPR and Genetic Engineering
- Molecular Biology Techniques and Applications
- Genetic Neurodegenerative Diseases
- Advanced biosensing and bioanalysis techniques
- Cancer-related molecular mechanisms research
- Mitochondrial Function and Pathology
- Slime Mold and Myxomycetes Research
- Chromosomal and Genetic Variations
- RNA and protein synthesis mechanisms
- Renal and related cancers
- Circular RNAs in diseases
- RNA Interference and Gene Delivery
- Genetic factors in colorectal cancer
- Tuberous Sclerosis Complex Research
Institute of Bioorganic Chemistry, Polish Academy of Sciences
2016-2025
University of Warsaw
1997-2024
Poznań University of Technology
2014-2018
Polish Academy of Sciences
1996-2015
Science Oxford
2015
University of Oxford
2015
Harvard University
2005-2010
Brigham and Women's Hospital
2005-2010
University of California, Los Angeles
2008
Field Crops Research Institute
2008
Summary C‐reactive protein (CRP) is a well‐documented marker of atherosclerotic cardiovascular disease risk. We resequenced CRP to identify comprehensive set common SNP variants, then studied and replicated their association with baseline level among apparently healthy subjects in the Women's Health Study (WHS; n = 717), Pravastatin Inflammation/CRP Evaluation trial (PRINCE; 1,110) Physicians' (PHS; 509) cohorts. The minor alleles four SNPs were consistently associated all three cohorts...
The biogenesis of human microRNAs (miRNAs) includes two RNA cleavage steps in which the activities RNases Drosha and Dicer are involved. miRNAs diverse lengths generated from different genes, that heterogeneous length produced a single miRNA gene. We determined solution structures many precursors analysed structural basis diversity using new measure: weighted average diced (WALDI). found asymmetrical motifs present precursor hairpins primarily responsible for by Dicer. High-resolution...
Mutant transcripts containing expanded CUG repeats in the untranslated region are a pathogenic factor myotonic dystrophy type 1 (DM1). The mutant RNA sequesters muscleblind-like (MBNL1) splicing and causes misregulation of alternative multiple genes that linked to clinical symptoms disease. In this study, we show either long CAG repeat or short synthetic induce aberrations typical DM1. Alternative defects also caused by translated normal cells transfected with ATXN3 gene construct derived...
Trinucleotide repeats (TNRs) are of interest in genetics because they used as markers for tracing genotype–phenotype relations and directly involved numerous human genetic diseases. In this study, we searched the genome reference sequence annotated exons (exome) presence uninterrupted triplet repeat tracts composed six or more repeated units. A list 32 448 TNRs 878 TNR-containing genes was generated is provided herein. We found that some repeats, specifically CNG, overrepresented, while CTT,...
Recent studies revealed a significant role of the gut fungal community in human health. Here, we investigated content and variation mycobiota among subjects from European population. We explored interplay between fungi various host-related sociodemographic, lifestyle, health, dietary factors. The study included 923 participants. Fecal DNA samples were analyzed by whole-metagenome high-throughput sequencing. Subsequently, taxonomic profiles determined accompanied computational statistical...
Abstract A growing body of evidence indicates an important role miRNAs in cancer; however, there is no definitive, convenient-to-use list cancer-related or miRNA genes that may serve as a reference for analyses cancer. To this end, we created 165 called the Cancer Census (CMC). The based on score, built various types functional and genetic particular cancer, e.g. miRNA–cancer associations reported databases, with cancer hallmarks, signals positive selection alterations presence...
Abstract Recent research indicates that gut microbiota may be vital in the advancement of melanoma. In this study, we found melanoma patients exhibited a distinct mycobiota structure compared with healthy participants. Candida albicans, dubliniensis, and Neurospora crassa were more abundant samples from melanoma, whereas Saccharomyces cerevisiae Debaryomyces hansenii less abundant. During anti–PD-1 treatment, relative amount Malassezia restricta C. albicans increased. A higher level...
Abstract Background MicroRNAs (miRNAs) are important genetic elements that regulate the expression of thousands human genes. Polymorphisms affecting miRNA biogenesis, dosage and target recognition may represent potentially functional variants. The consequences single nucleotide polymorphisms (SNPs) within critical sequences outside genes were previously demonstrated using both experimental computational methods. However, little is known about how copy number variations (CNVs) affect Results...
// Karol Czubak 1 , Marzena Anna Lewandowska 2, 3 Katarzyna Klonowska Krzysztof Roszkowski 4, 5 Janusz Kowalewski 3, 6 Marek Figlerowicz Piotr Kozlowski European Centre for Bioinformatics and Genomics, Institute of Bioorganic Chemistry, Polish Academy Sciences, Poznan, Poland 2 Molecular Oncology Genetics Department, Innovative Medical Forum, The Franciszek Lukaszczyk Center, Bydgoszcz, Department Thoracic Surgery Tumors, Nicolaus Copernicus University, Torun, Collegium Medicum, 4...
Leaf senescence is a tightly regulated developmental or stress-induced process. It accompanied by dramatic changes in cell metabolism and structure, eventually leading to the disintegration of chloroplasts, breakdown leaf proteins, internucleosomal fragmentation nuclear DNA ultimately death. In light global intense reorganization senescing transcriptome, measuring time-course gene expression patterns this model challenging due evident problems associated with selecting stable reference...
BackgroundmiRNAs are considered important players in oncogenesis, serving either as oncomiRs or suppressormiRs. Although the accumulation of somatic alterations is an intrinsic aspect cancer development and many cancer-driving mutations have been identified protein-coding genes, area functional miRNA genes heavily understudied.MethodsHere, based on analysis large genomic datasets, mostly whole-exome sequencing over 10,000 cancer/normal sample pairs deposited within TCGA repository, we...
Copy number variations (CNVs) greatly contribute to intraspecies genetic polymorphism and phenotypic diversity. Recent analyses of sequencing data for >1000 Arabidopsis (Arabidopsis thaliana) accessions focused on small did not include CNVs. Here, we performed genome-wide analysis identified large indels (50 499 bp) CNVs (500 bp larger) in these accessions. The fully overlap with 18.3% protein-coding genes, enrichment evolutionarily young genes involved stress defense. By combining both...