A5001443052- DNA Repair Mechanisms
- Genetics and Neurodevelopmental Disorders
- Genomics and Chromatin Dynamics
- Epigenetics and DNA Methylation
Hebrew University of Jerusalem
2014-2020
Common fragile sites (CFSs) are regions susceptible to replication stress and hotspots for chromosomal instability in cancer. Several features were suggested underlie CFS instability, however, these prevalent across the genome. Therefore, molecular mechanisms underlying remain unclear. Here, we explore transcriptional profile DNA timing (RT) under mild context of 3D genome organization. The results reveal a fragility signature, comprised TAD boundary overlapping highly transcribed large gene...
Abstract Common fragile sties (CFSs) are regions susceptible to replication stress and hotspots for chromosomal instability in cancer. Several features characterizing CFSs have been associated with their instability, however, these prevalent across the genome do not account all known CFSs. Therefore, molecular mechanism underlying CFS remains unclear. Here, we explored transcriptional profile temporal order of DNA (replication timing, RT) cells under conditions. We show that RT only a small...