A5025383713- Hydrogels: synthesis, properties, applications
- Surfactants and Colloidal Systems
- Polysaccharides Composition and Applications
- Ocular Surface and Contact Lens
- Acoustic Wave Resonator Technologies
- Ear Surgery and Otitis Media
The University of Texas Rio Grande Valley
2023-2024
Abstract Chemical permeation enhancers (CPEs) represent a prevalent and safe strategy to enable noninvasive drug delivery across skin‐like biological barriers such as the tympanic membrane (TM). While most existing CPEs interact strongly with lipid bilayers in stratum corneum create defects diffusion paths, their interactions system, polymers forming hydrogel, can compromise gelation, formulation stability, diffusion. To overcome this challenge, differing between hydrogel system are...
Aqueous solutions of poloxamer 407 (P407), a commercially available and nontoxic ABA triblock polymer (PEO-PPO-PEO), undergo solution-to-gel transition with increasing temperature are promising candidates for injectable therapeutics. The gel temperature, modulus, structure all dictated by concentration, preventing independent tuning these properties. Here, we show that addition BAB reverse poloxamers (RPs) to P407-based dramatically alters the gelation morphology. Gelation RP localization...