A5047148494- HIV Research and Treatment
- Dental Implant Techniques and Outcomes
- HIV/AIDS drug development and treatment
- Dental materials and restorations
- Oral microbiology and periodontitis research
- Surgical Sutures and Adhesives
- Corneal surgery and disorders
- Endodontics and Root Canal Treatments
- Orthopaedic implants and arthroplasty
- Virus-based gene therapy research
- Dental Trauma and Treatments
- Corneal Surgery and Treatments
- Glaucoma and retinal disorders
- HIV/AIDS Research and Interventions
- Helicobacter pylori-related gastroenterology studies
- Autoimmune and Inflammatory Disorders Research
- Rheumatoid Arthritis Research and Therapies
- Neonatal Health and Biochemistry
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- HIV-related health complications and treatments
- RNA modifications and cancer
- Kruppel-like factors research
- Conservation Techniques and Studies
- Spondyloarthritis Studies and Treatments
- Parkinson's Disease and Spinal Disorders
Centro Hospitalar de Vila Nova de Gaia
2019-2025
Escola Superior de Saúde Egas Moniz
2004-2024
Clinics Hospital of Ribeirão Preto
2023
University of Lisbon
1998-2019
Hospital do Servidor Público Estadual
2019
Administração Regional de Saúde de Lisboa e Vale do Tejo
2009
Hospital de São João
1994
Aims/Purpose: To evaluate the impact of preservation duration on endothelial quality corneal grafts and to identify most effective parameters for control these grafts. Methods: Retrospective analysis specular microscopy data from collected by Cornea Amniotic Membrane Department Unidade Local de Saúde Gaia e Espinho between 2021 2024. According department protocol, were stored at 4°C in Optisol‐GS (Bausch Lomb, Rochester, USA) solution, was performed 24 hours (D0), day 5 (D5), 10 (D10)...
Aims/Purpose: To evaluate the impact of preservation duration on endothelial quality corneal grafts and to identify most effective parameters for control these grafts. Methods: Retrospective analysis specular microscopy data from collected by Cornea Amniotic Membrane Department Unidade Local de Saúde Gaia e Espinho between 2021 2024. According department protocol, were stored at 4°C in Optisol‐GS (Bausch Lomb, Rochester, USA) solution, was performed 24 hours (D0), day 5 (D5), 10 (D10)...
O advento da tecnologia 5G representa uma transformação significativa no campo educação, com um impacto abrangente na forma como o aprendizado é facilitado. A escolha deste tema se justifica pela relevância crescente que a conectividade de alta velocidade possui era digital, ampliando acesso à educação qualidade. objetivo principal do estudo investigar implementação pode revolucionar as práticas educacionais, tornando-as mais interativas e inclusivas. Para isso, foi utilizada abordagem...
The aim of this study was to evaluate the possible relationships between polymorphisms in interleukin-1 (IL-1) A, IL-1B, and IL-1RN genes concentrations inflammatory mediators IL-1β, tumor necrosis factor-alpha (TNF-α), prostaglandin E2 (PGE2) peri-implant crevicular fluid (PICF). A cross-sectional analytical conducted on 51 patients with dental implants. Samples from buccal mucosa were obtained, genetic analysis performed using real-time polymerase chain reaction (PCR) technique for IL-1A...
ABSTRACT Viral infectivity factor (Vif) is one of the human immunodeficiency virus (HIV) accessory proteins and conserved in primate lentivirus group. This protein essential for viral replication vivo productive infection nonpermissive cells, such as peripheral blood mononuclear cells (PBMC). Vif counteracts an antiretroviral cellular named CEM15/APOBEC3G. Although HIV type 1 (HIV-1) (Vif1) can be functionally replaced by HIV-2 (Vif2), its identity very small. Most functional studies have...
Scientific evidence indicates that biological complications in dental implants tend to be concentrated a subset of individuals, which seems imply the host response may play determining role implant success. Over last few decades, several polymorphisms have been studied. Polymorphisms interleukin (IL) 1 gene cluster associated with periodontitis. There are some similar features sequence immunopathological events peri-implant and periodontal infections. We aimed investigate if individuals...
To investigate whether genetic variations in cytokine genes involved the pathogenesis of peri-implantitis are associated with occurrence peri-implantitis, an issue that remains controversial and may vary according to population evaluated.
Introduction: Different cancer cells, including those from breast cancer, show increased APOBEC3 activity [1 Alexandrov LB, Nik-Zainal S, Wedge DC, et al. Signatures of mutational processes in human cancer. Nature. 2013;500:415–421.[Crossref], [PubMed], [Web Science ®] , [Google Scholar],2 Roberts SA, Lawrence MS, Klimczak LJ, An APOBEC cytidine deaminase mutagenesis pattern is widespread cancers. Nature Genetics. 2013;45:970–976. doi:10.1038/ng.2702[Crossref], Scholar]], a single strand DNA...
Vif is a lentiviral accessory protein that counteracts the antiviral activity of cellular APOBEC3 (A3) cytidine deaminases in infected cells. The exact contribution each member A3 family for restriction HIV-2 still unclear. Thus, aim this work was to identify A3s with anti-HIV-2 and compare their potential HIV-1. We found A3G strong factor both types viruses A3C restricts neither HIV-1 nor HIV-2. Importantly, A3B exhibited potent against HIV-2, but its effect negligible Whereas packaged...
<h3>Background</h3> Rheumatoid arthritis (RA), psoriatic (PsA) and axial spondyloarthritis (axSpA) are diseases where inflammation plays a key role in their development have an increased risk of developing comorbid conditions. It is important to evaluate the comorbidities associated with these diseases. <h3>Objectives</h3> Our objective was prevalence RA, PsA axSpA patients from PANLAR´s register rheumatic (PANRED). <h3>Methods</h3> PANRED includes real world data Latin American consecutive...
Este artigo investigou a eficácia da Aprendizagem Baseada em Projetos (ABP) na promoção de uma aprendizagem significativa, demonstrando que integração entre teoria e prática promovia o engajamento ativo dos alunos desenvolvimento competências essenciais. O estudo abordou transformação métodos tradicionais ensino, enfatizando importância contextualização conteúdos criação ambientes dinâmicos. Utilizou-se pesquisa bibliográfica, conforme conceituada por Santana Narciso (2025), consistiu coleta...
Purpose: To report a case of intermediate cystinosis with an atypical presentation in which delayed non-treatment decision has been proved right over large period time. Methods: This is unique patient who underwent full ophthalmologic evaluations including anterior chamber optical coherence tomography on regular basis during 7-year follow-up period. Results: A 30-year-old woman photophobia was being studied by the Department Nephrology suspicion Alport syndrome. Slit-lamp examination showed...
Introduction Bleaching teeth to have a whiter and bright smile is popular trend currently one can do it at home, without technical support from dentists. However, whitening products are not innocuous the European legislation clear limiting content in hydrogen peroxide (H2O2), present or released, 6%, still, containing up 40% of H2O2 commercially available. In fact, contact time live tissues with agents usually small, which may restrict side effects, but on other hand, successively...
In vitro studies evaluating the cytotoxic potential of substances released from dental adhesives are lacking. The purpose this study was to compare cytotoxicity extracts Scotchbond Universal and Optibond Solo Plus, an adhesive in experimental phase: T1. 3T3 mouse fibroblast cells MG-63 osteoblast-like human osteosarcoma were exposed for 24 h serial extract dilutions. Cytotoxicity determined using MTT assay. For both cell lines, order obtained, unfiltered extracts, T1 (less cytotoxic) < Plus...