A5101548185- Algal biology and biofuel production
- Neurobiology and Insect Physiology Research
- Olfactory and Sensory Function Studies
- Plant and animal studies
- Neural dynamics and brain function
- Insect and Arachnid Ecology and Behavior
- Energy, Environment, Agriculture Analysis
- Muscle metabolism and nutrition
- Catalytic Processes in Materials Science
- Perovskite Materials and Applications
- Microbial Community Ecology and Physiology
- Monoclonal and Polyclonal Antibodies Research
- Advanced Chemical Sensor Technologies
- Biochemical effects in animals
- Helminth infection and control
- Mosquito-borne diseases and control
- Catalysts for Methane Reforming
- Metabolomics and Mass Spectrometry Studies
- Plant Parasitism and Resistance
- Insect behavior and control techniques
- Cell Image Analysis Techniques
- Advanced NMR Techniques and Applications
- Smart Grid Energy Management
- Photosynthetic Processes and Mechanisms
- Brucella: diagnosis, epidemiology, treatment
Indian Institute of Technology Kanpur
2016-2024
University of California, San Diego
2003-2024
Pennsylvania State University
2023
University of Agriculture Faisalabad
2023
University of Veterinary and Animal Sciences
2023
VA San Diego Healthcare System
2020-2021
San Diego Supercomputer Center
2003
Our reliance on agriculture for sustenance, healthcare, and resources has been essential since the dawn of civilization. However, traditional agricultural practices are no longer adequate to meet demands a burgeoning population amidst climate-driven challenges. Microalgae emerge as beacon hope, offering sustainable renewable source food, animal feed, energy. Their rapid growth rates, adaptability non-arable land non-potable water, diverse bioproduct range, encompassing biofuels...
Comparative analyses of multiple genomes are used extensively to examine the gains and losses chemosensory receptors across genus Drosophila. However, few studies have delved into functional olfactory characteristics. Here we assess function 20 species, identify describe several similar elements evolution. We document (a) minor changes in ligands based on amino acid substitutions, (b) major or perhaps entire receptor replacements, (c) that only a subject repeated changes, whereas 32 out 37...
Sustainable low-carbon energy solutions are critical to mitigating global carbon emissions. Algae-based platforms offer potential by converting dioxide into valuable products while aiding sequestration. However, scaling algae cultivation faces challenges like contamination in outdoor systems. Previously, our lab evolved Chlamydomonas pacifica, an extremophile green alga, which tolerates high temperature, pH, salinity, and light, making it ideal for large-scale bioproduct production,...
Bioprospecting algae strains with tolerance to extreme conditions such as pH, temperature, salinity, and light is crucial for advancing biotechnology environmental applications. However, traditional screening methods often involve significant costs labor, restricting their accessibility practical use. In this study, we developed validated low-cost, high-throughput techniques, predominantly employing agar plates liquid culture assays, effectively differentiate levels among various strains....
Abstract Algae biotechnology holds immense promise for revolutionizing the bioeconomy through sustainable and scalable production of various bioproducts. However, its development has been hindered by lack advanced genetic tools. This study introduces a synthetic biology approach to develop such tools, focusing on construction testing promoters. By analyzing conserved DNA motifs within promoter regions highly expressed genes across six different algal species, we identified cis-regulatory...
We present the comprehensive characterization of a newly identified microalga, Chlamydomonas pacifica, originally isolated from soil sample in San Diego, CA, USA. This species showcases remarkable biological versatility, including broad pH range tolerance (6-11.5), high thermal (up to 42 degree celsius), and salinity resilience 2% NaCl). Its amenability genetic manipulation sexual reproduction via mating, particularly between two opposing strains CC-5697 & CC-5699, now publicly available...
Microalgae offer a compelling platform for the production of commodity products, due to their superior photosynthetic efficiency, adaptability nonarable lands and nonpotable water, capacity produce versatile array bioproducts, including biofuels biomaterials. However, scalability microalgae as bioresource has been hindered by challenges such costly biomass related vulnerability pond crashes during large-scale cultivation. This study presents pipeline genetic engineering pilot-scale biodiesel...
A key aspect of behavioral inhibition is the ability to wait before acting. Failures in this form result impulsivity and are commonly observed various neuropsychiatric disorders. Prior evidence has implicated medial frontal cortex, motor orbitofrontal cortex (OFC), ventral striatum aspects inhibition. Here, using distributed recordings brain activity [with local-field potentials (LFPs)] rodents, we identified oscillatory patterns linked with action Low-frequency (δ) within premotor circuits...
Algae biotechnology holds immense promise for revolutionizing the bioeconomy through sustainable and scalable production of various bioproducts. However, their development has been hindered by lack advanced genetic tools. This study introduces a synthetic biology approach to develop such tools, focusing on construction testing promoters. By analyzing conserved DNA motifs within promoter regions highly expressed genes across six different algal species, we identified cis-regulatory elements...
Abstract Microalgae offer a compelling platform for the production of commodity products, due to their superior photosynthetic efficiency, adaptability non-arable lands and non-potable water, capacity produce versatile array bioproducts, including biofuels biomaterials. However, scalability microalgae as bioresource has been hindered by challenges such costly biomass related vulnerability pond crashes during large-scale cultivation. This study presents pipeline genetic engineering...
Computational prediction of how strongly an olfactory receptor (OR) responds to various odors can help in bridging the widening gap between large number receptors that have been sequenced and small experiments measuring their responses. Previous efforts this area predicted responses a some odors, using known same other odors. Here, we present method predict without any by available data about conspecific sequences. We applied ORs insects Drosophila melanogaster (both adult larva) Anopheles...
This paper presents an efficient way of representing the geometry and topology 3D images biological specimens derived from electron microscopy. A vector quantization algorithm is used in order to select a reduced set interior points that best approximates probability density function original volumetric data. Object's are obtained point by use alpha shapes theory.
Soy protein hydrolysates supplemented to cell cultures enhance integral viable density (IVCD) and recombinant production (Immunoglobulin, IgG). However, there is little understanding of the effect processing on hydrolysate functionality. In this study, were produced from meals heated at 121 °C/0-120 minutes. The heating decreased free amino acid reducing monosaccharide contents in (0.72-0.27% 3.3-2.6%) derived (14.7-7.1%, 16.9-7.9%). For all hydrolysates, IgG varied between 148-200%. A large...
Summary Computational prediction of how strongly an olfactory receptor responds to various odors can help in bridging the widening gap between large number receptors that have been sequenced and small experiments measuring their responses. Previous efforts this area predicted responses a some odors, using known same other odors. Here we present method predict without any responses, by available data about conspecific sequences. We applied insects Drosophila melanogaster (both adult larva)...
Many experimental studies have examined behavioral and electrophysiological responses of mosquitoes to odors. However, the differences across in data collection, processing, reporting make it difficult perform large-scale analyses combining from multiple studies. Here we extract standardize for 12 mosquito species, along with Drosophila melanogaster comparison, over 170 curate Mosquito Olfactory Response Ensemble (MORE), publicly available at https://neuralsystems.github.io/MORE. We...