A5003634398- Hippo pathway signaling and YAP/TAZ
- Axon Guidance and Neuronal Signaling
- Neurogenesis and neuroplasticity mechanisms
- Hereditary Neurological Disorders
- Prosthetics and Rehabilitation Robotics
- Wnt/β-catenin signaling in development and cancer
- Nerve injury and regeneration
- Muscle activation and electromyography studies
- Balance, Gait, and Falls Prevention
University of Bath
2017-2024
Peninsula College of Medicine and Dentistry
2017
Loss of the Merlin tumor suppressor and activation Hippo signaling pathway play major roles in control cell proliferation tumorigenesis. We have identified completely novel for effector Yes-associated protein (YAP) Schwann (SC) plasticity peripheral nerve repair after injury. Injury to nervous system (PNS) causes a dramatic shift SC molecular phenotype generation repair-competent SCs, which direct functional repair. find that loss these cells catastrophic failure axonal regeneration...
Abstract Myelination in the peripheral nervous system ( PNS ) is controlled by both positive and negative regulators within Schwann cells to ensure timely onset correct myelin thickness for saltatory conduction neurons. Transcription factors such as Sox10, octamer‐binding transcription factor 6 (Oct6) Krox20 form a regulatory network, whereas cJ un Sox2 oppose myelination cells. The role of p38 MAPK pathway has been studied myelination, but its precise function remains unclear, with effects...
Wearable robots are emerging as a viable and effective solution for assisting enabling people who suffer from balance mobility disorders. Virtual prototyping is powerful tool to design robots, preventing the costly iterative physical testing. Design of wearable through modelling, however, often involves computationally expensive error-prone multi-body simulations wrapped in an optimization framework simulate human–robot–environment interactions. This paper proposes make human–robot link...