A5031016264- Neural dynamics and brain function
- Olfactory and Sensory Function Studies
- Hearing, Cochlea, Tinnitus, Genetics
- Neurobiology and Insect Physiology Research
- Vestibular and auditory disorders
- Neuroscience and Neural Engineering
- Marine animal studies overview
- Cellular Mechanics and Interactions
- Cephalopods and Marine Biology
- EEG and Brain-Computer Interfaces
- Primate Behavior and Ecology
- Congenital heart defects research
- Antimicrobial Peptides and Activities
- Visual perception and processing mechanisms
- Receptor Mechanisms and Signaling
- Meat and Animal Product Quality
- Robotic Locomotion and Control
- Motor Control and Adaptation
- Action Observation and Synchronization
- Bat Biology and Ecology Studies
- Morphological variations and asymmetry
- Animal Genetics and Reproduction
- Animal Vocal Communication and Behavior
- Cleft Lip and Palate Research
- Zebrafish Biomedical Research Applications
University of California, Davis
2023-2024
Northwestern University
2016-2024
Oregon Health & Science University
2008-2012
Cochlear inner hair cells (IHCs) use Ca(2+)-dependent exocytosis of glutamate to signal sound information. Otoferlin (Otof), a C(2) domain protein essential for IHC and hearing, may serve as Ca(2+) sensor in vesicle fusion IHCs that seem lack the classical neuronal sensors synaptotagmin 1 (Syt1) Syt2. Support hypothesis otoferlin function comes from biochemical experiments, but additional roles late upstream have been indicated by physiological studies. Here, we tested functional equivalence...
Observation of terrestrial mammals suggests that they can follow the wind (anemotaxis), but sensory cues underlying this ability have not been studied. We identify a significant contribution to anemotaxis mediated by whiskers (vibrissae), modality previously studied only in context direct tactile contact. Five rats trained on five-alternative forced-choice airflow localization task exhibited performance decrements after vibrissal removal. In contrast, removal did disrupt control animals...
Prairie voles (Microtus ochrogaster) are one of the few mammalian species that monogamous and engage in biparental rearing their offspring. Biparental care impacts quantity quality offspring receives. The increased attention by father may translate to heightened tactile contact receives through licking grooming. In current study, we used electrophysiological multiunit recording techniques define organization perioral representation primary somatosensory area (S1) prairie voles. Functional...
Understanding neural function requires quantification of the sensory signals that an animal's brain evolved to interpret. These in turn depend on morphology and mechanics structures. Although house mouse (Mus musculus) is one most common model species used neuroscience, spatial arrangement its facial sensors has not yet been quantified. To address this gap, present study quantifies mouse, with a particular focus geometry vibrissae (whiskers). The develops equations establish relationships...
Abstract Whiskers (vibrissae) are important tactile sensors for most mammals. We introduce a novel approach to quantitatively compare 3D geometry of whisker arrays across species with different numbers and arrangements, focusing on harbor seals ( Phoca vitulina ), house mice Mus musculus ) Norway rats Rattus norvegicus ). all three decrease in arclength increase curvature from caudal rostral. They emerge the face elevation angles that vary linearly dorsoventral position, orientations...
The morphology of an animal's face will have large effects on the sensory information it can acquire. Here we quantify arrangement cranial structures rat, with special emphasis mystacial vibrissae (whiskers). Nearly all mammals vibrissae, which are generally arranged in rows and columns across face. serve a wide variety important behavioral functions, including navigation, climbing, wake following, anemotaxis, social interactions. To date, however, there few studies that compare vibrissal...
Nearly all mammals have a vibrissal system specialized for tactile sensation, composed of whiskers growing from sensor-rich follicles in the skin. When whisker deflects against an object, it deforms within follicle and exerts forces on mechanoreceptors inside. In addition, during active whisking behavior, muscle contractions around increases blood pressure ring sinus will affect deformation profile. To date, however, is not yet possible to experimentally measure how intact or its effects...
The rat vibrissal (whisker) system is one of the oldest and most important models for study active tactile sensing sensorimotor integration. It well established that primary sensory neurons in trigeminal ganglion respond to deflections only whisker, these are strongly tuned both speed direction individual whisker deflections. During whisking behavior, however, multiple whiskers will be deflected simultaneously. Very little known about how at central levels pathway integrate information...
Primates are characterized by specializations for manual manipulation, including expansion of posterior parietal cortex (PPC) and, in Catarrhines, evolution a dexterous hand and opposable thumb. Previous studies examined functional interactions between motor PPC New World monkeys galagos, inactivating M1 evoking movements from PPC. These found that portions depend on to generate movements. We now add species more closely resembles humans morphology PPC: macaques. Inactivating resulted all...
<b><i>Introduction:</i></b> The gray short-tailed opossum, <i>Monodelhis domestica</i> (<i>M. domestica</i>), is a widely used marsupial model species that presents unique advantages for neurodevelopmental studies. Notably their extremely altricial birth allows manipulation of postnatal pups at timepoints equivalent to embryonic stages placental mammals. A robust literature exists on the development opossums, but many researchers working in...
ABSTRACT Whiskers (vibrissae) are important tactile sensors for most mammals. We introduce a novel approach to quantitatively compare 3D geometry of whisker arrays across species with different numbers and arrangements, focusing on harbor seals (Phoca vitulina), house mice (Mus musculus) Norway rats (Rattus norvegicus). all three decrease in arclength increase curvature from caudal rostral. They emerge the face elevation angles that vary linearly dorsoventral position, orientations...
Abstract Nearly all mammals have a vibrissal system specialized for tactile sensation, composed of whiskers growing from sensor-rich follicles in the skin. Because whisker has no sensors along its length, an open question is how mechanoreceptors follicle transduce sensory signals. These are activated by deflection, so it essential to understand deforms within and may activate different populations ways. During active whisking behaviors, muscle contractions increases blood pressure ring sinus...