A5062080000- Lysosomal Storage Disorders Research
- Psychopathy, Forensic Psychiatry, Sexual Offending
- Homicide, Infanticide, and Child Abuse
- Carbohydrate Chemistry and Synthesis
- Metabolism and Genetic Disorders
- Mitochondrial Function and Pathology
- Proteoglycans and glycosaminoglycans research
- Trypanosoma species research and implications
- Cancer, Hypoxia, and Metabolism
- Crime Patterns and Interventions
- Crime, Deviance, and Social Control
- Forensic Toxicology and Drug Analysis
- Grief, Bereavement, and Mental Health
- Studies on Chitinases and Chitosanases
- Infectious Encephalopathies and Encephalitis
- RNA modifications and cancer
- Alcoholism and Thiamine Deficiency
- Deception detection and forensic psychology
- Wildlife Conservation and Criminology Analyses
- Tryptophan and brain disorders
- Prostate Cancer Treatment and Research
- Child Abuse and Trauma
- Transgenic Plants and Applications
- RNA regulation and disease
- Ubiquitin and proteasome pathways
Duke University Health System
2018-2025
Duke Medical Center
2023
Duke University Hospital
2023
Duke University
2019-2021
Federal Bureau of Investigation
2003-2009
The lack of biomarkers to identify target populations greatly limits the promise precision medicine for major depressive disorder (MDD), a primary cause ill health and disability. endogenously produced molecule acetyl-l-carnitine (LAC) is critical hippocampal function several behavioral domains. In rodents with depressive-like traits, LAC levels are markedly decreased signal abnormal glutamatergic dendritic plasticity. supplementation induces rapid lasting antidepressant-like effects via...
Significance We report that androgen receptor (AR) promotes glutaminase 1 (GLS1) expression and glutamine utilization to support the survival of prostate cancer (PCa) cells. Hormonal therapy inhibits AR decreases GLS1 achieve therapeutic effect. Our results suggest eventually tumor cells switch from AR-dependent KGA isoform androgen-independent enzymatically more potent GAC isoform, which increases can contribute development castration-resistant PCa. work has discovered a previously unknown...
Glutaric aciduria type I (GA-1) is an inborn error of metabolism with a severe neurological phenotype caused by the deficiency glutaryl-coenzyme A dehydrogenase (GCDH), last enzyme lysine catabolism. Current literature suggests that toxic catabolites in brain are produced locally and do not cross blood-brain barrier. In series experiments using knockout mice catabolic pathway liver cell transplantation, we uncovered GA-1 originated from liver. Moreover, characteristic lethal mouse model was...
Abstract This article summarizes and compares information on seven interviewed serial killers in an ongoing project designed to study similarities differences among these individuals. The aim of this is increase our collective knowledge the dynamics murder by examining perpetrators' backgrounds, as well unique ways which they view themselves world around them. Although qualitative interview research alone not sufficient fully understand such behavior, it useful many ways. Some discussed...
Mucopolysaccharidoses (MPSs) are complex lysosomal diseases that result in the accumulation of glycosaminoglycans (GAGs) urine, blood, and tissues. Lysosomal enzymes responsible for GAG degradation defective MPSs. GAGs including chondroitin sulfate (CS), dermatan (DS), heparan (HS), keratan (KS) biomarkers This article describes a stable isotope dilution-tandem mass spectrometric method quantifying CS, DS, HS urine samples. The methanolyzed to uronic/iduronic acid-N-acetylhexosamine or...
Major depressive disorder (MDD) is a primary psychiatric illness worldwide; there dearth of new mechanistic models for the development better therapeutic strategies. Although we continue to discover individual biological factors, major challenge identification integrated, multidimensional traits underlying complex heterogeneity depression and treatment outcomes. Here, set out ascertain emergence novel mitochondrial mediator epigenetic function acetyl-L-carnitine (LAC) in relation previously...
Nonfamily child abductions have a low rate of occurrence despite the media attention and public hysteria that these types cases often attract. Although annual incident is low, nonfamily are emotionally charged crimes can rapidly overwhelm law enforcement resources. The 24-hour period following an abduction critical, must be prepared to respond immediately effectively. purpose present research obtain demographic background history on convicted abductors who murdered their victims. Data for...
Cellular metabolism in cancer is significantly altered to support the uncontrolled tumor growth. How metabolic alterations contribute hormonal therapy resistance and disease progression of prostate (PCa) remains poorly understood. Here we report a glutaminase isoform switch mechanism that mediates initial therapeutic effect but eventual failure PCa. Androgen deprivation inhibits expression kidney-type (KGA), splicing 1 (GLS1) upregulated by androgen receptor (AR), achieve suppressing...