A5100646975- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Fatty Acid Research and Health
- Immune cells in cancer
- Adipose Tissue and Metabolism
- Respiratory Support and Mechanisms
- Lipid metabolism and biosynthesis
- Neuroscience of respiration and sleep
- Obstructive Sleep Apnea Research
- Anesthesia and Neurotoxicity Research
- High Altitude and Hypoxia
- Neuroinflammation and Neurodegeneration Mechanisms
- Autophagy in Disease and Therapy
- Neuroscience and Neuropharmacology Research
- Toxoplasma gondii Research Studies
- Sleep and Wakefulness Research
- Neonatal Respiratory Health Research
- Phosphodiesterase function and regulation
- Quinazolinone synthesis and applications
- Thermal Regulation in Medicine
- Cancer Immunotherapy and Biomarkers
- RNA Interference and Gene Delivery
- Occupational exposure and asthma
- Biochemical effects in animals
- Neonatal and fetal brain pathology
- Pulmonary Hypertension Research and Treatments
Binzhou University
2015-2025
Binzhou Medical University
2015-2025
Abstract Chronic intermittent hypoxia (CIH) is a serious consequence of obstructive sleep apnoea (OSA) and has deleterious effects on central neurons neurocognitive functions. This study examined if protocatechuic acid (PCA) could improve learning memory functions rats exposed to CIH conditions explore potential mechanisms. Neurocognitive were evaluated in male SD by step-through passive avoidance test Morris water maze assay following exposure or room air conditions. Ultrastructure changes...
Abstract Our aim was to investigate the effects of phycocyanin (PC) on bleomycin (BLM)-induced pulmonary fibrosis (PF). In this study, C57 BL/6 wild-type (WT) mice and toll-like receptor (TLR) 2 deficient were treated with PC for 28 days following BLM exposure. Serum lung tissues collected 3, 7 28. Data shows significantly decreased levels hydroxyproline (HYP), vimentin, surfactant-associated protein C (SP-C), fibroblast specific protein-1 (S100A4) α-smooth muscle actin (α-SMA) but...
The mechanisms of chronic intermittent hypoxia (CIH)-induced cognitive deficits remain unclear. Here, our study found that about 3 months CIH treatment induced lipid droplets (LDs) accumulation in hippocampal nerve and glia cells C57BL/6 mice, caused severe neuro damage including neuron lesions, neuroblast (NB) apoptosis abnormal glial activation. Studies have shown the neuronal metabolism disorders might contribute to induced-hippocampal impairment. Mechanistically, results showed pyruvate...
Aim of the Study: Idiopathic pulmonary fibrosis (IPF) is a lethal human disease with short survival time and few treatment options. In this study, we aim to demonstrate that cyclic nucleotide phosphodiesterase 1A (PDE1A), Ca2+/calmodulin-stimulating PDE family member, plays critical role in induction angiogenesis lung. Materials Methods: To induce damage, adult male SD rats were treated bleomycin dose 6 mg/kg body weight by single intratracheal instillation. For vivo silencing PDE1A rat...
Hypoxia is a type of cellular stress that may result in apoptosis and autophagy. The molecular mechanisms underlying the association between autophagy remain unclear, particularly hypoxic conditions. Transmission electron microscope, AO‑PI staining, flow cytometry western blot were used to examine crosstalk Rat alveolar II epithelial RLE‑6TN cells cultured long‑term environment established by cobalt (II) chloride. It was demonstrated occurred under Treatment with inhibitor 3‑methyladenine...
Cancer cell vaccines with strong specificity and low tolerance have been revealed to be a promising option for oncology treatment. Various antigen forms, including tumor lysate glutaraldehyde-fixed cells, intensively used in cancer vaccine preparation. However, the most effective form has not yet identified. In present study, antitumor efficiency of prepared by these two forms was systematically investigated. Murine H22 hepatocellular carcinoma cells were conjugated Freund's adjuvant prepare...
Sleep deprivation (SD) could cause a sequence of neurobehavioral deficits and physiological consequences. Isorhamnetin (ISOR) has been verified to have neuronal protective, anti‐inflammatory anti‐oxidative effects. This article aimed explore the mechanism under neuroprotective effect ISOR against 72h SD‐induced anxiety like behavior, oxidative stress, neuroinflammation in mice. The ameliorating on learning memory impairment was evaluated by Open field test (OFT) Morris water maze tests...
Introduction: Obstructive sleep apnea-hypopnea syndrome (OSAHS) is a common disorder that causes severe physiological disturbance. Lots of evidences showed OSAHS was an important associated comorbidity can affect pulmonary fibrosis patient’s survival. Until now, the potential mechanisms by which OSAS accelerate progression lung are still unclear. Constructing pathological model chronic intermittent hypoxia (CIH), present study aimed to explore progress and mechanism injury caused OSAHS....